Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Quirks of track preservation and formation are more likely than pre- avian flight and ultrafast dinosaurs AI翻译
  作者：Falkingham, Peter L.; Lallensack, Jens N.
  作者单位：Liverpool John Moores University; Universidade Federal de Minas Gerais
• Validating new limits for human thermoregulation AI翻译
  作者：Meade, Robert D.; O'Connor, Fergus K.; Richards, Brodie J.; Tetzlaff, Emily J.; Wagar, Katie E.; Harris-Mostert, Roberto C.; Egube, Theodore; McCormick, James J.; Kenny, Glen P.
  作者单位：University of Ottawa; Harvard University; Harvard T.H. Chan School of Public Health; University of Ottawa; Ottawa Hospital Research Institute
  摘要：Recent projections suggest that large geographical areas will soon experience heat and humidity exceeding limits for human thermoregulation. The survivability limits modeled in that research were based on laboratory studies suggesting that humans cannot effectively thermoregulate in wet bulb temperatures (T-wb) above 26 to 31 degrees C, values considerably lower than the widely publicized theoretical threshold of 35 degrees C. The newly proposed empirical limits were derived from the T-wb corr...
• Structural and functional dynamics of human cone cGMP- phosphodiesterase important for photopic vision (vol 122, e2419732121, 2024) AI翻译
  作者：Singh, Sneha; Srivastava, Dhiraj; Boyd, Kimberly; Artemyev, Nikolai O.
• Signaling networks in cancer stromal senescent cells establish malignant microenvironment AI翻译
  作者：Zhang, Yue; Wang, Teh-Wei; Tamatani, Maho; Zeng, Xinyi; Nakamura, Lindo; Omori, Satotaka; Yamaguchi, Kiyoshi; Hatakeyama, Seira; Shimizu, Eigo; Yamazaki, Satoshi; Furukawa, Yoichi; Imoto, Seiya; Johmura, Yoshikazu; Nakanishi, Makoto
  作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; Kanazawa University
  摘要：The tumor microenvironment (TME) encompasses various cell types, blood and lymphatic vessels, and noncellular constituents like extracellular matrix (ECM) and cytokines. These intricate interactions between cellular and noncellular components contribute to the development of a malignant TME, such as immunosuppressive, desmoplastic, angiogenic conditions, and the formation of a niche for cancer stem cells, but there is limited understanding of the specific subtypes of stromal cells involved in ...
• Deficiency in platelet 12-lipoxygenase exacerbates inflammation and disease severity during SARS-CoV-2 infection AI翻译
  作者：Andrade, Ana Claudia dos S. P.; Lacasse, Emile; Dubuc, Isabelle; Gudimard, Leslie; Gravel, Annie; Puhm, Florian; Campolina-Silva, Gabriel; Queiroz-Junior, Celso; Allaeys, Isabelle; Prunier, Julien; Wallen, Oumaima Azeggouar; Dumais, Elizabeth; Belleannee, Clemence; Droit, Arnaud; Flamand, Nicolas; Boilard, Eric; Flamand, Louis
  作者单位：Laval University; Laval University; Universidade Federal de Minas Gerais; Laval University; Laval University; Laval University Hospital; Laval University; Laval University; Laval University
  摘要：Platelets, known for maintaining blood balance, also participate in antimicrobial defense. Upon severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, platelets become hyperactivated, releasing molecules such as cytokines, granule contents, and bioactive lipids. The key effector biolipids produced by platelets include 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-hydroxyeicosatrienoic acid (12-HETrE), produced by 12-lipoxygenase (12-LOX), and prostaglandins and thromboxane, ...
• Hair cell apoptosis and deafness in Tmc1 mutations AI翻译
  作者：Beurg, Maryline; Konrad, Dakota Elle; Fettiplace, Robert
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：Transmembrane channel-like protein 1 (TMC1), a pore-forming component of the mechano-electrical transducer (MET) channel in cochlear outer hair cells, is subject to numerous mutations causing deafness and hair cell death. We studied mice harboring semidominant mutations Tmc1 p.T416K, p.M412K, and p.D569N, which all display functional MET channels at postnatal day (P)6 but become deaf by P21. Early signs of concomitant hair cell apoptosis were assayed in neonatal Tmc1 mutants by labeling with C...
• Nonpathological inflammation drives the development of an avian flight adaptation (vol 120, e2219757120, 2023) AI翻译
  作者：Rashid, Dana J.; Sheheen, Joseph R.; Huey, Tori; Surya, Kevin; Sanders, Jackson B.; Horner, John R.; Voyich, Jovanka; Chapman, Susan C.
• The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom (vol 121,e2313440121,2024) AI翻译
  作者：Hogan, Michael P.; Holding, Matthew L.; Nystrom, Gunnar S.; Colston, Timothy J.; Bartlett, Daniel A.; Mason, Andrew J.; Ellsworth, Schyler A.; Rautsaw, Rhett M.; Lawrence, Kylie C.; Strickland, Jason L.; He, Bing; Fraser, Peter; Margres, Mark J.; Gilbert, David M.; Gibbs, H. Lisle; Parkinson, Christopher L.; Rokyta, Darin R.
• Brain aging shows nonlinear transitions, suggesting a midlife critical window for metabolic intervention AI翻译
  作者：Antal, Botond B.; van Nieuwenhuizen, Helena; Chesebro, Anthony G.; Strey, Helmut H.; Jones, David T.; Clarke, Kieran; Weistuch, Corey; Ratai, Eva-Maria; Dill, Ken A.; Mujica-Parodi, Lilianne R.
  作者单位：State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; State University of New York (SUNY) System; Stony Brook University; Mayo Clinic; University of Oxford; Memorial Sloan Kettering Cancer Center; The Santa Fe Institute
  摘要：Understanding the key drivers of brain aging is essential for effective prevention and treatment of neurodegenerative diseases. Here, we integrate human brain and physiological data to investigate underlying mechanisms. Functional MRI analyses across four large datasets (totaling 19,300 participants) show that brain networks not only destabilize throughout the lifetime but do so along a nonlinear trajectory, with consistent temporal landmarks of brain aging starting in midlife (40s). Compariso...
• Cytoskeleton remodeling mediated by circRNA- YBX1 phase separation suppresses the metastasis of liver cancer (vol 120,e2220296120,2023) AI翻译
  作者：Liu, Boqiang; Shen, Hao; He, Jing; Jin, Binghan; Tian, Yuanshi; Li, Weiqi; Hou, Lidan; Zhao, Weijun; Nan, Junjie; Zhao, Jia; Shen, Jiliang; Yu, Hong; Wang, Yifan; Shan, Ge; Shi, Liang; Cai, Xiujun