Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Communicative mentalization is limited in nonhuman great apes AI翻译
  作者：Tauzin, Tibor
  作者单位：University of Vienna; University of Vienna
• Framework to identify innovative sources of value creation from platform technologies AI翻译
  作者：Jones, Charles H.; Beitelshees, Marie; Hill, Andrew; Griffiths, Dean; Murphy, Matthew; Kapadia, Ketan; Dolsten, Mikael; True, Jane M.
  作者单位：Pfizer; Pfizer USA
  摘要：Platform technologies are fundamentally reshaping the pharmaceutical industry, offering unprecedented potential for innovation across multiple therapeutic areas. However, traditional valuation models, focused on single-asset metrics, struggle to capture the full spectrum of value these technologies create. This paper presents a comprehensive framework for evaluating the innovative sources of value creation enabled by platform technologies throughout the drug development lifecycle. Through a sy...
• An RNA-binding regulatory cascade controls the switch from proliferation to differentiation in the Drosophila male germ cell lineage AI翻译
  作者：Harris, Devon E.; Kim, Jongmin J.; Stern, Sarah R.; Vicars, Hannah M.; Matias, Neuza R.; Gallicchio, Lorenzo; Baker, Catherine C.; Fuller, Margaret T.
  作者单位：Stanford University; Stanford University; Stanford University; Cornell University
  摘要：The switch from precursor cell proliferation to onset of differentiation in adult stem cell lineages must be carefully regulated to produce sufficient progeny to maintain and repair tissues, yet prevent overproliferation that may enable oncogenesis. In the Drosophila male germ cell lineage, spermatogonia produced by germ line stem cells undergo a limited number of transit amplifying mitotic divisions before switching to the spermatocyte program that sets up meiosis and eventual spermatid diffe...
• Energetics and evolutionary fitness AI翻译
  作者：Vermeij, Geerat J.; Grosberg, Richard K.; Roopnarine, Peter D.
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; California Academy of Sciences
  摘要：It has long been recognized that energy is the currency of evolution, but contrasting conceptions of the relationship between energy and adaptation have yielded different interpretations. In the equal fitness paradigm (EFP), fitness (defined as the energetic equivalent of surviving offspring per generation) is held to be a constant within and between species in a steady- state, zero- sum closed system of constant energy availability. The fossil record, however, indicates that living space and ...
• Structural insights into the ubiquitin- independent midnolin- proteasome pathway AI翻译
  作者：Peddada, Nagesh; Zhong, Xue; Yin, Yan; Lazaro, Danielle Renee; Wang, Jianhui; Lyon, Stephen; Choi, Jin Huk; Bai, Xiao-Chen; Moresco, Eva Marie Y.; Beutler, Bruce
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The protein midnolin (MIDN) augments proteasome activity in lymphocytes and dramatically facilitates the survival and proliferation of B-lymphoid malignancies. MIDN binds both to proteasomes and to substrates, but the mode of interaction with the proteasome is unknown, and the mechanism by which MIDN facilitates substrate degradation in a ubiquitin-independent manner is incompletely understood. Here, we present cryoelectron microscopy (cryo-EM) structures of the substrate-engaged, MIDN-bound h...
• We need better ways to re- evaluate conservation policies when they're founded on flawed research AI翻译
  作者：Shoemaker, Kevin T.; Loope, Kevin J.
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Virginia Polytechnic Institute & State University
• Testing theories of political persuasion using AI AI翻译
  作者：Argyle, Lisa P.; Busby, Ethan C.; Cubler, Joshua R.; Lyman, Alex; Olcott, Justin; Pond, Jackson; Wingate, David
  作者单位：Brigham Young University; Brigham Young University
  摘要：Despite its importance to society and many decades of research, key questions about the social and psychological processes of political persuasion remain unanswered, often due to data limitations. We propose that AI tools, specifically generative large language models (LLMs), can be used to address these limitations, offering important advantages in the study of political persuasion. In two preregistered online survey experiments, we demonstrate the potential of generative AI as a tool to stud...
• Five-body recombination of identical bosons AI翻译
  作者：Higgins, Michael D.; Greene, Chris H.
  作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：This work treats resonant collisions between five identical ultracold bosons in the framework of the adiabatic hyperspherical representation. The five-body recombination rate coefficient is quantified using a semiclassical description in conjunction with an analysis of the lowest five-body hyperspherical adiabatic potential curves in a scattering length regime with no universal weakly bound tetramers, trimers, or dimers. A comparison is made between these results and the only existing experime...
• The expanded immunoregulatory protease network in mosquitoes is governed by gene coexpression AI翻译
  作者：Morejon, Bianca; Michel, Kristin
  作者单位：Kansas State University
  摘要：Serine protease cascades regulate key innate immune responses. Their activation cleaves a series of inactive protease zymogens, which then activate downstream effector enzymes, ensuring a rapid response. In mosquitoes, these cascades involve clip-domain serine proteases and their noncatalytic homologs (CLIPs), whose make-up and structural organization are not fully understood. Here, we systematically assessed the contribution of individual CLIPs to humoral immunity in Anopheles gambiae, by per...
• Multiscale biased chemical space remodeling for developing APLNR agonists with anti-HFpEF efficacy AI翻译
  作者：Sun, Qiu; Tian, Xiaowen; Tan, Lun; Deng, Yan; Liu, Sicen; Xiong, Yixiao; Feng, Yuying; Wang, Yujia; Zhang, Lele; Zhu, Jiayi; Xiao, Huan; Shao, Zhenhua; Guo, Yingqiang; Yan, Wei; Li, Tao; Ouyang, Liang
  作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Shanghai University; Tianfu Jincheng Laboratory
  摘要：Heart failure with preserved ejection fraction (HFpEF) represents a significant global health burden, yet effective pharmacotherapies remain elusive. The angiotensin-like 1 receptor, also known as the apelin receptor (APLNR), is a promising target for treating HFpEF due to its role in modulating cardiovascular function. Despite the cardioprotective effects of endogenous ligand, apelin, achieving G-protein-biased agonism for therapeutic benefit poses a significant challenge. In this study, we u...