Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Distinct oxytocin signaling pathways synergistically mediate rescue- like behavior in mice AI翻译
  作者：Zhang, Feng - Rui; Liu, Juan; Wen, Jieqi; Zhang, Zi- Yan; Li, Yijia; Song, Eric; Hu, Li; Chen, Zhou- Feng
  作者单位：Washington University (WUSTL); Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shenzhen Bay Laboratory; Shenzhen Medical Academy of Research & Translation (SMART); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Spontaneous rescue behavior enhances the well- being and survival of social animals, yet the neural mechanisms underlying the recognition and response to conspecifics in need remain unclear. Here, we report that observer mice experience distress when encountering anesthetized conspecifics, prompting spontaneous rescue- like behavior toward the unconscious mice. This behavior facilitates the earlier awakening of anesthetized mice while simultaneously alleviating stress in the helper mice. Our f...
• A symbiotic gene stimulates aggressive behavior favoring the survival of parasitized caterpillars AI翻译
  作者：Wu, Zhiwei; Wu, Xiaotong; Wang, Zhizhi; Ye, Xiqian; Pang, Lan; Wang, Yanping; Zhou, Yuenan; Chen, Ting; Zhou, Sicong; Wang, Zehua; Sheng, Yifeng; Zhang, Qichao; Chen, Jiani; Tang, Pu; Shen, Xingxing; Huang, Jianhua; Drezen, Jean- Michel; Strand, Michael R.; Chen, Xuexin
  作者单位：Zhejiang University; Universite de Tours; University System of Georgia; University of Georgia
  摘要：Animals often exhibit increased aggression in response to starvation, while parasites often manipulate host behavior. In contrast, underlying molecular mechanisms for these behavioral changes are mostly unknown. The diamondback moth, Plutella xylostella, is an agricultural pest that feeds on cruciferous plants as larvae, while Cotesia vestalis is a parasitoid wasp that parasitizes diamondback moth larvae. In this study, we determined that unparasitized diamondback moth larvae exhibit increased...
• Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity AI翻译
  作者：Fountain, Adam J.; Waller, Natalie J. E.; Cheung, Chen - Yi; Jowsey, William; Chrisp, Michael T.; Troll, Mark; Edelstein, Paul H.; Cook, Gregory M.; Mcneil, Matthew B.; Ramakrishnan, Lalita
  作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Otago; Queensland University of Technology (QUT)
  摘要：Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis. Bedaquiline targets mycobacterial ATP synthase but the predominant route to clinical bedaquiline resistance is via upregulation of the MmpS5L5 efflux pump due to mutations that inactivate the transcriptional repressor Rv0678. Here, we show that the MmpS5L5 efflux pump reduces su...
• Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination AI翻译
  作者：Staples, Sabrina C. R.; Yin, Hao; Sutherland, Frances S. K.; Prescott, Emma K.; Tinney, Dylan; Hamilton, Douglas W.; Goldman, Daniel; Poepping, Tamie L.; Ellis, Christopher G.; Pickering, J. Geoffrey
  作者单位：Western University (University of Western Ontario); University Western Ontario Hospital; Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); London Health Sciences Centre
  摘要：Intussusceptive angiogenesis is an increasingly recognized vessel duplication process that generates and reshapes microvascular beds. However, the mechanism by which a vessel splits into two is poorly understood. Particularly vexing is formation of the hallmark transluminal endothelial cell bridge. How an endothelial cell comes to cross a flowing lumen rather than line it is enigmatic. To elucidate this, we used a microvessel-on-a-chip strategy, creating a microconduit coherently lined with fl...
• Psychological impacts of climate change on US youth AI翻译
  作者：Vercammen, Ans; Wray, Britt; Crider, Yoshika S.; Belkin, Gary; Lawrance, Emma L.
  作者单位：Curtin University; University of Queensland; Stanford University; University of California System; University of California Berkeley; Stanford University; Columbia University; New York University; Imperial College London; Imperial College London
  摘要：Awareness of the threats of climate change is causing distress in increasingly documented ways, with youth particularly affected. Experiences such as climate distress and eco-anxiety have implications for the health and well-being of societies and economies, including individuals' mental health and future planning, as well as their agency beliefs. Here, we show in a large sample of US youth (n = 2,834, ages 16 to 24) that the majority of US youth experience moderate climate distress and some f...
• Nonnative tree invaders lead to declines in native tree species richness AI翻译
  作者：Liu, Yunpeng; Scheiner, Samuel M.; Hogan, J. Aaron; Thomas, Matthew B.; Soltis, Pamela S.; Guralnick, Robert P.; Soltis, Douglas E.; Lichstein, Jeremy W.
  作者单位：State University System of Florida; University of Florida; University of York - UK; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：Biological invasions are profoundly altering Earth's ecosystems, but generalities about the effects of nonnative species on the diversity and productivity of native communities have been elusive. This lack of generality may reflect the limited spatial and temporal extents of most previous studies. Using >5 million tree measurements across eastern US forests from 1995 to 2023, we quantified temporal trends in tree diversity and biomass. We then analyzed community- level changes in native tree d...
• Roquin exhibits opposing effects on RNA stem- loop stability through its two ROQ domain binding sites AI翻译
  作者：Tants, Jan-Niklas; Walbrun, Andreas; Kollwitz, Lucas; Friedrich, Katharina; Rief, Matthias; Schlundt, Andreas
  作者单位：Goethe University Frankfurt; Goethe University Frankfurt; Technical University of Munich; Universitat Greifswald
  摘要：The interaction of mRNA and regulatory proteins is critical for posttranscriptional control. For proper function, these interactions, as well as the involved protein and RNA structures, are highly dynamic, and thus, mechanistic insights from structural biology are challenging to obtain. In this study, we employ a multifaceted approach combining single-molecule force spectroscopy (SMFS) with NMR spectroscopy to analyze the concerted interaction of the two RNA-binding interfaces (A-site and B-si...
• In situ generated hydrogen- bonding microenvironment in functionalized MOF nanosheets for enhanced CO2 electroreduction AI翻译
  作者：Yang, Ge; Huang, Jiajia; Gu, Weizhi; Lin, Zhongyuan; Wang, Qingyu; Kang, Rong; Liu, Jing - Yao; Sun, Zhihu; Zheng, Xusheng; Jiao, Long; Jiang, Hai - Long
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Jilin University
  摘要：The microenvironment around catalytic sites plays crucial roles in enzymatic catalysis while its precise control in heterogeneous catalysts remains challenging. Herein, the coordinatively unsaturated metal nodes of Hf- based metal- organic framework nanosheets are simultaneously codecorated with catalytically active Co(salen) units and adjacent pyridyl- substituted alkyl carboxylic acids via a post modification route. By varying pyridyl- substituted alkyl carboxylic acids, the spatial position...
• Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia AI翻译
  作者：Bertulfo, Kalay; Perez-Duran, Pablo; Miller, Hannah; Ma, Cindy; Ambesi-Impiombato, Alberto; Samon, Jeremy; Mackey, Adam; Lin, Wen- Hsuan Wendy; Ferrando, Adolfo A.; Palomero, Teresa
  作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Bristol-Myers Squibb
  摘要：Gamma Secretase Inhibitors (GSIs) effectively block oncogenic Notch homolog-1 (NOTCH1), a characteristic feature of T cell acute lymphoblastic leukemias (T-ALL). However, their clinical application has been stalled by the induction of severe gastrointestinal toxicity resulting from the inhibition of NOTCH signaling in the gut, which translates into increased goblet cell differentiation. Genome-wide CRISPR loss-of-function screen in the colon cancer cell line LS174T identified the neddylation p...
• Colony pattern multistability emerges from a bistable switch AI翻译
  作者：Chu, Pan; Zhu, Jingwen; Ma, Zhixin; Fu, Xiongfei
  作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Microbial colony development hinges upon a myriad of factors, including mechanical, biochemical, and environmental niches, which collectively shape spatial patterns governed by intricate gene regulatory networks. The inherent complexity of this phenomenon necessitates innovative approaches to comprehend and compare the mechanisms driving pattern formation. Here, we unveil the multistability of bacterial colony patterns, where bacterial colony patterns can stabilize into multiple distinct types...