Proceedings of the National Academy of Sciences of the United States of America

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• Enhanced chloroplast FtsZ-ring constriction by the ARC6-ARC3 module in Arabidopsis AI翻译
  作者：Du, Wenbin; Cao, Lingyan; Zhou, Yuelong; Jackson, Shanelle; Naeem, Maryam; Chen, Zhaoyu; Yang, Yue; Glynn, Jonathan M.; Porter, Katie J.; Zhang, Runlong; He, Qian; Liu, Moyang; Xu, Jie; Liang, Wanqi; Feng, Peiqiang; Osteryoung, Katherine W.; Chen, Cheng
  作者单位：Jiangxi Agricultural University; Pfizer; Pfizer USA; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Michigan State University; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Chloroplast division, a process tightly linked to the energy demands of plants, is initiated by the formation of the stromal filamenting temperature-sensitive Z (FtsZ) ring. The Z ring is highly dynamic, and its constriction provides the essential force for chloroplast division. However, the regulatory mechanisms governing Z-ring dynamics and constriction remain poorly understood. Here, we report that the chloroplast inner envelope membrane (IEM) protein ACCUMULATION AND REPLICATION OF CHLOROP...
• Relaxation to universal non- Maxwellian equilibria in a collisionless plasma (vol 122, e2417813122, 2025) AI翻译
  作者：Ewart, Robert J.; Nastac, Michael L.; Bilbao, Pablo J.; Silva, Thales; Silva, Luis O.; Schekochihin, Alexander A.
• Editorial Expression of Concern for Fries et al., Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior AI翻译
  作者：Fries, Alison B. Wismer; Ziegler, Toni E.; Kurian, Joseph R.; Jacoris, Steve; Pollak, Seth D.
• Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase-phosphatase AI翻译
  作者：Osika, Kristin R.; Gaynes, Matthew N.; Christianson, David W.
  作者单位：University of Pennsylvania
  摘要：Drimenol synthase from Aquimarina spongiae (AsDMS) is a highly unusual chimera that integrates two distinct, sequential isoprenoid processing activities within a single polypeptide chain. AsDMS catalyzes the class II cyclization of farnesyl diphosphate (FPP) to form drimenyl diphosphate, which then undergoes enzyme- catalyzed hydrolysis to yield drimenol, a bioactive sesquiterpene alcohol with antifungal and anticancer properties. Here, we report the X- ray crystal structures of AsDMS and its ...
• Monocytes use protrusive forces to generate migration paths in viscoelastic collagen-based extracellular matrices AI翻译
  作者：Adebowale, Kolade; Allan, Cole; Ha, Byunghang; Saraswathibhatla, Aashrith; Zhu, Junqin; Indana, Dhiraj; Popescu, Medeea C.; Demirdjian, Sally; Martinez, Hunter A.; Esclamado, Alex; Yang, Jin; Bassik, Michael C.; Franck, Christian; Bollyky, Paul L.; Chaudhuri, Ovijit
  作者单位：Stanford University; Stanford University; University of California System; University of California San Diego; Stanford University; Stanford University; Stanford University; University of Texas System; University of Texas Austin; Stanford University; University of Wisconsin System; University of Wisconsin Madison
  摘要：Circulating monocytes are recruited to the tumor microenvironment, where they can differentiate into macrophages that mediate tumor progression. To reach the tumor microenvironment, monocytes must first extravasate and migrate through the type-1 collagen rich stromal matrix. The viscoelastic stromal matrix around tumors not only stiffens relative to normal stromal matrix, but often exhibits enhanced viscous characteristics, as indicated by a higher loss tangent or faster stress relaxation rate...
• Single antisense oligonucleotides correct diverse splicing mutations in hotspot exons AI翻译
  作者：Duan, Chaorui; Rong, Stephen; Buerer, Luke; Neil, Christopher R.; Zhong, Yu; Lyu, Zhuoyang; Savatt, Juliann M.; Strande, Natasha T.; Fairbrother, William G.
  作者单位：Brown University; Brown University; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); Imperial College London; Brown University
  摘要：Mutations that impact splicing play a significant role in disease etiology but are not fully understood. To characterize the impact of exonic variants on splicing in 71 clinically actionable disease genes in asymptomatic people, we analyzed 32,112 exonic mutations from ClinVar and Geisinger MyCode using a minigene reporter assay. We identify 1,733 splice-disrupting mutations, with the most extreme variants likely being deleterious. We report that these variants are not distributed evenly acros...
• Reply to Larsen and Riisgård: Fluid dynamics of choanocyte chambers AI翻译
  作者：Ogawa, Takumi; Koyama, Shuji; Omori, Toshihiro; Kikuchi, Kenji; de Maleprade, Helene; Goldstein, Raymond E.; Ishikawa, Takuji
  作者单位：Tohoku University; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; University of Cambridge; Tohoku University
• An N- terminal domain specifies developmental control by the SMAX1-LIKE family of transcriptional regulators in Arabidopsis thaliana AI翻译
  作者：Chang, Sun Hyun; George, Wesley J.; Nelson, David C.
  作者单位：University of California System; University of California Riverside
  摘要：SMAX1-LIKE (SMXL) proteins in plants are cellular signaling hubs, many of which are posttranslationally regulated by karrikins from smoke, the plant hormones strigolactones (SLs), and/or cues such as light and nutrients. SMXL proteins control diverse aspects of growth, development, and environmental adaptation in plants through transcriptional corepression and interactions with transcriptional regulator proteins. In flowering plants, the SMXL family comprises four phylogenetic clades with diff...
• Solution mapping of MHC- I:TCR interactions using a minimalistic protein system AI翻译
  作者：Woodward, Claire H.; Chaudhuri, Apala; Chen, Xiaojing Tina; White, William L.; Garcia, K. Christopher; Baker, David; Sgourakis, Nikolaos G.
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
  摘要：Recognition of epitopic peptide antigens presented on class I major histocompatibility complex (MHC- I) proteins by T cell receptors (TCRs) forms the cornerstone of immune surveillance, leading to a plethora of adaptive immune responses. Characterization of TCR:peptide/MHC- I interactions is critical for understanding immune recognition, and developing immunotherapies, but the large variation in docking orientations of TCRs on their peptide/MHC- I targets challenges structural modeling. NMR sp...
• Near-zero photon bioimaging by fusing deep learning and ultralow-light microscopy AI翻译
  作者：Sheneman, Lucas; Balogun, Sulaimon; Johnson, Jill L.; Harrison, Maria J.; Vasdekis, Andreas E.
  作者单位：University of Idaho; University of Idaho; University of Idaho; Cornell University; Boyce Thompson Institute for Plant Research; United States Department of Energy (DOE); Pacific Northwest National Laboratory
  摘要：Enhancing the reliability and reproducibility of optical microscopy by reducing specimen irradiance continues to be an important biotechnology target. As irradiance levels are reduced, however, the particle nature of light is heightened, giving rise to Poisson noise, or photon sparsity that restricts only a few (0.5%) image pixels to comprise a photon. Photon sparsity can be addressed by collecting approximately 200 photons per pixel; this, however, requires long acquisitions and, as such, sub...