Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt AI翻译
  作者：Zaglia, Tania; Campo, Antonio; Moro, Nicola; Di Mauro, Vittoria; Borile, Giulia; Menabo, Roberta; Antonucci, Salvatore; Poli, Laura; Campesan, Marika; Carullo, Pierluigi; Martinazzi, Sara; Luciani, Giovanni B.; Hammer, Karin; Pesce, Paola; Bariani, Riccardo; Faggian, Giuseppe; Maier, Lars; Ventura, Laura; De Stefani, Diego; Mammucari, Cristina; Rizzuto, Rosario; Catalucci, Daniele; Di Lisa, Fabio; Mongillo, Marco
  作者单位：University of Padua; Veneto Institute Molecular Medicine; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); University of Verona; University of Regensburg; University of Padua; University of Padua; University of Padua; Consiglio Nazionale delle Ricerche (CNR)
  摘要：Regulation of mitochondrial Ca2+ uptake is critical in cardiac adaptation to chronic stressors. Abnormalities in Ca2+ handling, including mitochondrial uptake mechanisms, have been implicated in pathological heart hypertrophy. Enhancing mitochondrial Ca2+uniporter (MCU) expression has been suggested to interfere with maladaptive development of heart failure. Here, we addressed whether MCU modulation affects the cardiac response to pressure overload. MCU content was quantified in human and muri...
• How circuits for habits are formed within the basal ganglia AI翻译
  作者：Grillner, Sten
  作者单位：Karolinska Institutet
  摘要：Recent findings show that stereotyped movement sequences (habits) need the cortex in the learning phase, but after learning, the cortex can be inactivated, and the movement still be performed flawlessly. The motor program is dependent on the sensorimotor part of the dorsolateral striatum (DLS) and on synaptic plasticity in the thalamostriatal synapses. New findings from several laboratories have revealed a highly precise spatially interactive organization within the basal ganglia [DLS, substan...
• S- nitrosylation- triggered secretion of mycobacterial PknG leads to phosphorylation of SODD to prevent apoptosis of infected macrophages AI翻译
  作者：Saha, Saradindu; Roy, Sadhana; Hazra, Arnab; Das, Debayan; Kumar, Vimal; Singh, Amit Kumar; Singh, Ajay Vir; Mondal, Rajesh; Dasgupta, Somdeb Bose
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kharagpur; Indian Council of Medical Research (ICMR); ICMR - National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra; Indian Council of Medical Research (ICMR); Indian Council of Medical Research (ICMR); ICMR - National Institute for Research in Tuberculosis (NIRT); Indian Council of Medical Research (ICMR); ICMR - National Institute for Research in Environmental Health (NIREH)
  摘要：The tuberculosis-causing agent Mycobacterium tuberculosis (M.tb) establishes its niche inside macrophages by secretion of several virulence factors and engaging many host factors. Mycobacterial infection of macrophages results in a proinflammatory trigger-mediated secretion of TNFc. Protein kinase G (PknG), a Serine/Threonine kinase, is essential for mycobacterial survival within the macrophage. Pathogenic mycobacteria, upon infection, can trigger the secretion of proinflammatory cytokine TNFc...
• Directed evolution of a sequence- specific covalent protein tag for RNA labeling AI翻译
  作者：Huang, Rongbing; Ting, Alice Y.
  作者单位：Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
  摘要：Efficient methods for conjugating proteins to RNA are needed for RNA delivery, imaging, editing, interactome mapping, and barcoding applications. Noncovalent coupling strategies using viral RNA binding proteins such as MS2/MCP have been widely applied but are limited by tag size, sensitivity, and dissociation over time. We took inspiration from a sequence- specific, covalent protein-DNA conjugation method based on the Rep nickase of a porcine circovirus called HUH tag. Though wild- type HUH pr...
• Mussel- inspired cross- linking mechanisms enhance gelation and adhesion of multifunctional mucin- derived hydrogels AI翻译
  作者：Degen, George D.; Stevens, Corey A.; Carcamo-Oyarce, Gerardo; Song, Jake; Bej, Raju; Tang, Peng; Ribbeck, Katharina; Haag, Rainer; Mckinley, Gareth H.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Free University of Berlin; Pontificia Universidad Catolica de Chile
  摘要：Mucus supports human health by hydrating, lubricating, and preventing infection of wet epithelial surfaces. The beneficial material properties and bioactivity of mucus stem from glycoproteins called mucins, motivating the development of mucin- derived hydro- gels for wound dressings and antifouling coatings. However, these applications require robust gelation and adhesion to a wide range of substrates. Inspired by the chemical cross- linking and water- tolerant adhesion of marine mussel adhesi...
• Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates AI翻译
  作者：Limkul, Sirawich; Phiwthong, Tannatorn; Wanvimonsuk, Supitcha; Seabkongseng, Tuangrak; Aunkam, Phirom; Jaree, Phattarunda; Luangtrakul, Waruntorn; Mahanil, Kanjana; Teamtisong, Kamonluck; Tittabutr, Panlada; Teaumroong, Neung; Sarnow, Peter; Wang, Han-Ching; Somboonwiwat, Kunlaya; Boonchuen, Pakpoom
  作者单位：Suranaree University of Technology; Chulalongkorn University; Mahidol University; Suranaree University of Technology; Stanford University; National Cheng Kung University; National Cheng Kung University
  摘要：Invertebrates mostly use innate immunity to counteract pathogenic infections. In this study, shrimp was used as a model organism to explore the functions of circular RNAs (circRNAs) derived from white spot syndrome virus (WSSV). We identified four viral transcriptomic data of WSSV- infected shrimp. CircVP28, which contains an internal ribosome entry site, was further characterized to determine its potential as a template for protein translation. We observed the presence of a truncated, circRNA...
• JFK, a Kelch domain- containing F- box protein, links the SCF complex to p53 regulation (vol 106, pg 10195, 2009) AI翻译
  作者：Sun, Luyang; Shi, Lei; Li, Wenqian; Yu, Wenhua; Liang, Jing; Zhang, Hua; Yang, Xiaohan; Wang, Yan; Li, Ruifang; Yao, Xingrong; Yi, Xia; Shang, Yongfeng
• Substrate and climate determine terrestrial litter decomposition AI翻译
  作者：Wu, Qiuxia; Ni, Xiangyin; Sun, Xinyao; Chen, Zihao; Hong, Songbai; Berg, Bjoern; Zheng, Mianhai; Chen, Ji; Zhu, Jingjing; Ai, Ling; Zhang, Yichen; Wu, Fuzhong
  作者单位：Fujian Normal University; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Ministry of Natural Resources of the People's Republic of China; University of Helsinki; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Peking University
  摘要：Litter decomposition is a fundamental biogeochemical process for carbon flux and nutrient cycling in terrestrial ecosystems, yet the global variation in decomposition rates and their covariations with climate and substrate are not fully understood. Here, we synthesized a global dataset of 6,733 independent observations across six continents to illustrate the climatic and substrate controls over litter decomposi-tion. The average decomposition rates of various litter types ranged from 0.74 to 4...
• Measurement of α-synuclein as protein cargo in plasma extracellular vesicles (vol 121, e2408949121, 2024) AI翻译
  作者：Gilboa, Tal; Ter-Ovanesyan, Dmitry; Wang, Shih-Chin; Whiteman, Sara; Kannarkat, George T.; Church, George M.; Chen-Plotkin, Alice S.; Walt, David R.
• The evolution of signaling and monitoring in plant-fungal networks AI翻译
  作者：Scott, Thomas W.; Kiers, E. Toby; West, Stuart A.
  作者单位：University of Oxford; University of St Andrews; Vrije Universiteit Amsterdam
  摘要：Experiments have shown that when one plant is attacked by a pathogen or herbivore, this can lead to other plants connected to the same mycorrhizal network up- regulating their defense mechanisms. It has been hypothesized that this represents signaling, with attacked plants producing a signal to warn other plants of impending harm. We examined the evolutionary plausibility of this and other hypotheses theoretically. We found that the evolution of plant signaling about an attack requires restric...