Proceedings of the National Academy of Sciences of the United States of America

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• CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response AI翻译
  作者：Vicary, Alison C.; Jordan, Sydney N. Z.; Mendes, Marisa; Swaminath, Sharmada; Castro, Lennice K.; Porter, Justin S.; Vo, Kevin D.; Russell, Alistair B.
  作者单位：University of California System; University of California San Diego
  摘要：Transcription of interferons upon viral infection is critical for cell-intrinsic innate immunity. This process is influenced by many host and viral factors. To identify host factors that modulate interferon induction within cells infected by influenza A virus, we developed CRISPR with Transcriptional Readout using sequencing (CRITR-seq). CRITR-seq is a method linking CRISPR guide sequence to activity at a promoter of interest. Employing this method, we find that depletion of the Negative Elong...
• FADDDED filaments coordinate complex IIa assembly during TNF-induced apoptosis AI翻译
  作者：Chen, Ying; Huynh, Vinh Thang; Lai, Lihua; Liu, Ping; Li, Tongyang; Tan, Yaw Bia; Chew, Che Shin; Velazquez, Amhed Missael Vargas; Samsudin, Firdaus; Marzinek, Jan K.; Bond, Peter J.; Wu, Bin; Luo, Dahai; Tergaonkar, Vinay
  作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Nanyang Technological University; Nanyang Technological University; Agency for Science Technology & Research (A*STAR); A*STAR - Bioinformatics Institute (BII); National University of Singapore; Nanyang Technological University; National Centre for Infectious Diseases Singapore; National University of Singapore
  摘要：Extrinsic apoptosis is initiated by signaling from death receptors, leading to the assembly of RIPK1, FADD, and caspase-8 complex. Subsequently, caspase-8 forms a filamentous structure through the oligomerization of its tandem death effector domain (tDED), resulting in caspase activation and cell death. Although the DED of FADD (FADDDED) is homologous to the tDEDs of caspase-8 (casp8tDED) and both oligomerize to function, the functional form of FADDDED oligomer in extrinsic apoptosis remains u...
• Into the belly of the brainstem: The neurons of the extended enteric nervous system AI翻译
  作者：Moore, Jeffrey D.
  作者单位：University of Southern California
• A critical role for Vibrio parahaemolyticus LPS to mediate evasion of host immune response during infection AI翻译
  作者：Jaishankar, Jananee; Yang, Hyojik; O'Keefe, Ian P.; Tenaglia, Brandon M.; Kinch, Lisa N.; Ernst, Robert K.; Orth, Kim
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Vibrio parahaemolyticus (V. para), a Gram-negative halophilic bacterium, is the leading cause of seafood-borne gastroenteritis. While the cytotoxic and enterotoxic capabilities of this bacterium have been previously investigated, the strategies it employs to circumvent innate immune detection by the host remain poorly understood. Bacterial lipopolysaccharide (LPS) serves as the major pathogen-associated molecular pattern that triggers host inflammatory responses, and its lipid A structure cont...
• Keys to the global treeline formation: Thermal limit for its position and moisture for the taxon-specific variation AI翻译
  作者：Xie, Yuyang; Shen, Zehao; Camarero, J. Julio; Penuelas, Josep; Wang, Xuejing; Li, Jitang; Rao, Wenge; Chen, Xiangwu; Zhao, Fu; Feng, Xiao
  作者单位：Peking University; Peking University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Yunnan University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Autonomous University of Barcelona
  摘要：Alpine treeline is a prominent biogeographic feature worldwide, determined by the physiological limit of tree life form. There are considerable variations in the various dimensions of physiological limit among tree taxa; thus, varied environmental drivers and spatial patterns are expected for different tree taxa at treelines. However, such taxonomic variability of treeline is often overlooked in large-scale studies. Here, we assembled, to our knowledge, the most comprehensive dataset of tree s...
• Keldysh tuning of photoluminescence in a lead halide perovskite crystal AI翻译
  作者：Zhang, Zhuquan; Ning, Honglie; Liu, Zi-Jie; Hou, Jin; Mohite, Aditya D.; Baldini, Edoardo; Gedik, Nuh; Nelson, Keith A.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Rice University; Rice University; University of Texas System; University of Texas Austin
  摘要：In 1964, Keldysh laid the groundwork for strong-field physics in atomic, molecular, and solid-state systems by delineating a ubiquitous transition from multiphoton absorption to classical field-driven electron tunneling under intense electromagnetic waves. While both processes in semiconductors can generate carriers and result photon emission through electron-hole recombination, the low quantum yields most materials have hindered direct observation of the Keldysh crossover. Leveraging the larg...
• Confined colloidal droplets dry to form circular mazes AI翻译
  作者：Beechey-Newman, Ilaria; Kizilova, Natalya; Hennig, Andreas Andersen; Flekkoy, Eirik Crude; Eiser, Erika
  作者单位：Norwegian University of Science & Technology (NTNU); Warsaw University of Technology; University of Oslo; Norwegian University of Science & Technology (NTNU); University of Cambridge
  摘要：During drying, particle-laden sessile droplets will leave so-called coffee-stain rings behind. This phenomenon is well known and well understood (Deegan et al., Nature 389, 827-829 (1997). Here, we show that when particle-laden droplets confined in a slit are allowed to evaporate very slowly, they do not deposit coffee rings, but form surprisingly intricate, circular maze-like patterns. We present experiments that illustrate this pattern formation and discuss the factors that determine when su...
• Exploring glycoform- dependent dynamic modulations in human immunoglobulin G via computational and experimental approaches AI翻译
  作者：Yanaka, Saeko; Sakae, Yoshitake; Miyanoiri, Yohei; Yamaguchi, Takumi; Isono, Yukiko; Kondo, Sachiko; Iwasaki, Miyuki; Onitsuka, Masayoshi; Yagi, Hirokazu; Kato, Koichi
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; The Exploratory Research Center on Life & Living Systems (ExCELLS); National Institutes of Natural Sciences (NINS) - Japan; Research Organization for Information Science & Technology (RIST); University of Osaka; Japan Advanced Institute of Science & Technology (JAIST); Nagoya City University; Tokushima University
  摘要：We investigate the impact of glycoform alterations on the dynamic structure of the human immunoglobulin G1 (IgG1) Fc region using integrated computational and experimental approaches. Four distinct IgG1-Fc glycoforms, varying in core fucosylation and nonreducing terminal galactosylation, were generated through a combination of cell engineering and in vitro enzymatic reactions. Stable-isotope-assisted NMR spectroscopy, incorporating both glycan and protein signals, revealed that galactosylation...
• 撤稿声明: Retraction for Jaijyan et al., New intranasal and injectable gene therapy for healthy life extension AI翻译
  作者：Jaijyan, Dabbu Kumar; Selariu, Anca; Cosme, Ruth Cruz -; Tong, Mingming; Yang, Shaomin; Stefa, Alketa; Kekich, David; Sadoshima, Junichi; Herbig, Utz; Tang, Qiyi; Church, George; Parrish, Elizabeth L.; Zhu, Hua
• Biochar in the circular bionutrient economy AI翻译
  作者：Lehmann, Johannes; Barrios, Edmundo; Devault, Mariana; Li, Lucinda; Nelson, Rebecca; Six, Johan; Trimmer, John
  作者单位：Cornell University; Cornell University; Cornell University; Food & Agriculture Organization of the United Nations (FAO); Cornell University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Syracuse University
  摘要：The circular bionutrient economy is defined here as the circular economy of nutrients in managed organic residues. Here, we posit that biochar technology can stimulate the circular bionutrient economy by meeting the following three requirements: 1) nutrients are captured in a dry form, increasing market value and lowering transportation cost; 2) individual nutrients can be captured separately and combined as needed for particular plants and soils; 3) all pathogens and most pollutants can be re...