Proceedings of the National Academy of Sciences of the United States of America

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• Translocations contribute to population rescue in an imperiled woodpecker AI翻译
  作者：Lewanski, Alexander L.; Linderoth, Tyler; Thompson, Greg; Tringali, Angela; Angell, Emily; Bowman, Reed; Fitzpatrick, Sarah W.
  作者单位：Michigan State University; Michigan State University; Michigan State University
  摘要：Anthropogenic destruction and fragmentation of habitat restrict many species to small, isolated populations, which often experience high extirpation risk. Restoring connectivity through translocations is one approach for mitigating the demographic and genetic perils faced by small populations. However, translocation interventions often lack substantial postrelease monitoring, and thus important information including the performance of translocated individuals, the long- term impacts on the rec...
• Suturing fragmented landscapes: Mosaic hybrid zones in plants may facilitate ecosystem resiliency AI翻译
  作者：Massatti, Rob; Faske, Trevor M.; Barnes, Ivana M.; Leger, Elizabeth A.; Parchman, Thomas L.; Richardson, Bryce A.; Knowles, L. Lacey
  作者单位：United States Department of the Interior; United States Geological Survey; University of Michigan System; University of Michigan; Nevada System of Higher Education (NSHE); University of Nevada Reno; United States Department of Agriculture (USDA); United States Forest Service
  摘要：Many widespread plant taxa of western North America have diversified into phenotypically and genetically divergent lineages due to complex biogeographic histories across heterogeneous landscapes. Mosaic hybrid zones can form when geographically co-occurring, yet environmentally distinct, lineages cross-pollinate and form hybrids that occupy unique environmental niches absent of a geographic cline. This expands the total environmental space across which parental and hybrid individuals grow, res...
• From science to impact: Conserving ecological connectivity in large conservation landscapes AI翻译
  作者：Naidoo, Robin; Aylward, Cody; Elliott, Wendy; Keeley, Annika; Kinnaird, Margaret; Knight, Michael; Papp, Cristian- Remus; Thapa, Kanchan; Antelo, Rafael
  作者单位：World Wildlife Fund; University of British Columbia; Nelson Mandela University; Babes Bolyai University from Cluj
  摘要：Implementing ecological connectivity conservation in large landscapes requires cutting- edge science combined with consideration of ecological, socioeconomic, and cultural factors that collectively shape the outcomes of conservation efforts. We outline a theory of change (ToC) for connectivity conservation to improve the ecological condition of landscapes and biodiversity and the ecosystem services upon which humans depend. We review connectivity conservation efforts on four continents in larg...
• An electron- bifurcating plug to a protein nanowire in tungsten- dependent aldehyde detoxification AI翻译
  作者：Feng, Xiang; Schut, Gerrit J.; Putumbaka, Saisuki; Li, Huilin; Adams, Michael W. W.
  作者单位：Van Andel Institute; University System of Georgia; University of Georgia; California Institute of Technology
  摘要：Members of the tungsten-containing oxidoreductase (WOR) family, which contain a tungstopyranopterin (Tuco) cofactor, are typically either monomeric (WorL) or heterodimeric (WorLS). These enzymes oxidize aldehydes to the corresponding acids while reducing the redox protein ferredoxin. They have been structurally characterized mainly using WORs from hyperthermophilic archaea. The WORs of some bacteria contain three additional subunits of the BfuABC family and these chimeric WorABCSL enzymes cata...
• Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling (vol 122, e2425868122, 2025) AI翻译
  作者：Gao, Forson; Ye, Fuzhou; Jovanovic, Milija; Buck, Martin; Zhang, Xiaodong
  作者单位：Imperial College London; Imperial College London; University of Belgrade; Francis Crick Institute
• TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination AI翻译
  作者：Halford, Julia; Senatore, Amanda J.; Berryman, Sage; Semidey, Destinee; Munoz, Antonio; Doan, Ryan A.; Coombs, Adam M.; Noimany, Brandon; Emberley, Katie; Emery, Ben; Monk, Kelly R.; Murthy, Swetha E.
  作者单位：Oregon Health & Science University; Oregon Health & Science University
  摘要：Infantile hypomyelinating leukodystrophy 19 (HLD19) is a rare genetic disorder where patients exhibit reduced myelin in central nervous system (CNS) white matter tracts and present with varied neurological symptoms. The causative gene TMEM63A encodes a mechanosensitive ion channel whose role in myelination is largely unexplored. Our study shows that TMEM63A is a major regulator of oligodendrocyte (OL)-dependent myelination in the CNS. In mouse and zebrafish, Tmem63a inactivation led to early d...
• Unprecedentedly high global forest disturbance due to fire in 2023 and 2024 AI翻译
  作者：Potapov, Peter; Tyukavina, Alexandra; Turubanova, Svetlana; Hansen, Matthew C.; Giglio, Louis; Hernandez-Serna, Andres; Lima, Andre; Harris, Nancy; Stolle, Fred
  作者单位：University System of Maryland; University of Maryland College Park
  摘要：Global forests provide key ecosystem services, from climate regulation to biodiversity habitat, but are under increasing pressure from the combined impacts of climate and land use change. Here, we show that forest disturbance due to fire is growing globally, with the most dramatic increases in intact forest landscapes, highlighting an existential threat to remaining high biomass, high biodiversity forests. The global annual area of forest disturbance due to fire for 2023 and 2024 was highest s...
• Impact forecasting for humanitarianism: Opportunities and challenges AI翻译
  作者：Baylis, Kathy; Lentz, Erin C.
  作者单位：University of California System; University of California Santa Barbara; University of Texas System; University of Texas Austin
• Nature- based solutions for urban sustainability AI翻译
  作者：Cook, Elizabeth M.; Kim, Yeowon; Grimm, Nancy B.; McPhearson, Timon; Anderson, Pippin; Bulkeley, Harriet; Collier, Marcus J.; Diep, Loan; Morato, Jordi; Zhou, Weiqi
  作者单位：Columbia University; Korea University; Arizona State University; Arizona State University-Tempe; The New School; Cary Institute of Ecosystem Studies; Stockholm University; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics; University of Cape Town; Durham University; Utrecht University; Trinity College Dublin; Universitat Politecnica de Catalunya; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS
• T lymphocyte-specific deletion of SHPT and SHP2 promotes activation- induced cell death of CD4+T cells and impairs antitumor response AI翻译
  作者：Foster, Connor J. R.; Du, Jasper; Pundel, Oscar; Geer, Mitchell J.; Ripert, Ryan C.; Liu, Jia; Heim, Taylor A.; Araki, Kiyomi Y.; Lund, Amanda W.; Wang, Jun; Neel, Benjamin G.
  作者单位：NYU Langone Medical Center; New York University; New York University
  摘要：SHP1 (PTPN6) and SHP2 (PTPN11) are closely related protein- tyrosine phosphatases (PTPs), which are autoinhibited until their SH2 domains bind paired tyrosine- phosphorylated immunoreceptor tyrosine- based inhibitory/switch motifs (ITIMs/ITSMs). These PTPs bind overlapping sets of ITIM/ITSM- bearing proteins, suggesting that they might have some redundant functions. By studying T cell-specific single and double knockout mice, we found that SHP1 and SHP2 redundantly restrain na & iuml;ve T cell...