Proceedings of the National Academy of Sciences of the United States of America

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• Supporting Information for Sutter et al., Electrochemical cofactor recycling of bacterial microcompartments (vol 121, e2414220121, 2024) AI翻译
  作者：Sutter, Markus; Utschig, Lisa M.; Niklas, Jens; Paul, Sathi; Kahan, Darren N.; Gupta, Sayan; Poluektov, Oleg G.; Ferlez, Bryan H.; Tefft, Nicholas M.; TerAvest, Michaela A.; Hickey, David P.; Vermaas, Josh V.; Ralston, Corie Y.; Kerfeld, Cheryl A.
• Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes AI翻译
  作者：Langley, Caroline A.; Dietzen, Peter A.; Emerman, Michael; Tenthorey, Jeannette L.; Malik, Harmit S.
  作者单位：University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of California System; University of California San Francisco; Howard Hughes Medical Institute; Fred Hutchinson Cancer Center
  摘要：Mx proteins, first identified in mammals, encode potent antiviral activity against a wide range of viruses. Mx proteins arose within the Dynamin superfamily of proteins (DSP), which mediate critical cellular processes, such as endocytosis and mitochondrial, plastid, and peroxisomal dynamics. Despite their crucial role, the evolutionary origins of Mx proteins are poorly understood. Through comprehensive phylogenomic analyses with progressively expanded taxonomic sampling, we demonstrate that Mx...
• Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity AI翻译
  作者：Wang, Zixuan; Chen, Xiaoyun; Zhu, Chunchun; Fan, Sijia; Tang, Jinhua; Deng, Hongyan; Sun, Xueyi; Liu, Xing; Xiao, Wuhan
  作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences
  摘要：Interferon regulatory factor 3 (IRF3) is the key transcription factor in the type I IFN signaling pathway, whose activation is regulated by multiple posttranslational modifica-tions. Here, we identify SMYD3, a lysine methyltransferase, as a negative regulator of IRF3. SMYD3 interacts with IRF3 and catalyzes the dimethylation of IRF3 at lysine 39. This modification reduces IRF3 phosphorylation, dimerization, and subsequent nuclear translocation, leading to the inhibition of downstream type I in...
• Completion of lunar magma ocean solidification at 4.43 Ga AI翻译
  作者：Dauphas, Nicolas; Zhang, Zhe J.; Chen, Xi; Barboni, Melanie; Szymanowski, Dawid; Schoene, Blair; Leya, Ingo; Mckeegan, Kevin D.
  作者单位：University of Chicago; Arizona State University; Arizona State University-Tempe; Swiss Federal Institutes of Technology Domain; ETH Zurich; Princeton University; University of Bern; University of California System; University of California Los Angeles
  摘要：Crystallization of the lunar magma ocean yielded a chemically unique liquid residuum named KREEP. This component is expressed as a large patch on the near side of the Moon and a possible smaller patch in the northwest portion of the Moon's South Pole-Aitken basin on the far side. Thermal models estimate that the crystallization of the lunar magma ocean (LMO) could have spanned from 10 and 200 My, while studies of radioactive decay systems have yielded inconsistent ages for the completion of LM...
• Characterizing progenitor cells in developing and injured spinal cord: Insights from single- nucleus transcriptomics and lineage tracing AI翻译
  作者：Zhang, Qi; Wu, Xianming; Fan, Yongheng; Zhang, Haipeng; Yin, Man; Xue, Xiaoyu; Yin, Yanyun; Jin, Chen; Quan, Rui; Jiang, Peipei; Liu, Yongguang; Yu, Cheng; Kuang, Wenhao; Chen, Bing; Li, Jiayin; Chen, Zhong; Hu, Yali; Xiao, Zhifeng; Zhao, Yannan; Dai, Jianwu
  作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Southern Medical University - China; Nanjing University; Southern Medical University - China; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of BioMedical Engineering - CAMS; Peking Union Medical College
  摘要：Various mature tissue- resident cells exhibit progenitor characteristics following injury. However, the existence of endogenous stem cells with multiple lineage potentials in the adult spinal cord remains a compelling area of research. In this study, we present a cross- species investigation that extends from development to injury. We used single- nucleus transcriptomic sequencing and genetic lineage tracing to characterize neural cells in the spinal cord. Our findings show that ciliated epend...
• Floodplain forests drive fruit-eating fish diversity at the Amazon Basin-scale AI翻译
  作者：Correa, Sandra Bibiana; Coronado-Franco, Karold V.; Jezequel, Celine; Rodrigues, Amanda Cantarute; Evans, Kristine O.; Granger, Joshua J.; Ter Steege, Hans; do Amaral, Ieda Leao; Coelho, Luiz de Souza; Wittmann, Florian; de Almeida Matos, Francisca Dionizia; Lima Filho, Diogenes de Andrade; Salomao, Rafael P.; Castilho, Carolina V.; Guevara, Juan Ernesto; Veiga Carim, Marcelo de Jesus; Phillips, Oliver L.; Fernandez Piedade, Maria Teresa; Demarchi, Layon O.; Schongart, Jochen; Cardenas Revilla, Juan David; Martins, Maria Pires; Irume, Mariana Victoria; da Silva Guimaraes, Jose Renan; Ramos, Jose Ferreira; Quaresma, Adriano Costa; Pitman, Nigel C. A.; Luize, Bruno Garcia; Moraes de Leao Novo, Evlyn Marcia; Venticinque, Eduardo Martins; Freire Silva, Thiago Sanna; Nunez Vargas, Percy; Manzatto, Angelo Gilberto; Costa Reis, Neidiane Farias; Terborgh, John; Casula, Katia Regina; Honorio Coronado, Euridice N.; Carlos Montero, Juan; Monteagudo Mendoza, Abel; Feldpausch, Ted R.; Durgante, Flavia Machado; Castano Arboleda, Nicolas; Marimon, Beatriz S.; Marimon-Junior, Ben Hur; Killeen, Timothy J.; Vasquez, Rodolfo; Mostacedo, Bonifacio; Assis, Rafael L.; do Amaral, Dario Dantas; Householder, John Ethan; Simon, Marcelo Fragomeni; de Medeiros, Marcelo Brilhante; de Queiroz, Helder Lima; Lopes, Maria Aparecida; Lima Magalhaes, Jose Leonardo; Stevenson, Pablo R.; Ladvocat Cintra, Bruno Barcante; Araujo-Murakami, Alejandro; Baker, Tim R.; Feitosa, Yuri Oliveira; Mogollon, Hugo F.; Duivenvoorden, Joost F.; Ferreira, Leandro Valle; de Toledo, Jose Julio; Comiskey, James A.; Lopes, Aline; Damasco, Gabriel; Vicentini, Alberto; Cornejo Valverde, Fernando; Gomes, Vitor H. F.; Alonso, Alfonso; Dallmeier, Francisco; de Aguiar, Daniel P. P.; Gribel, Rogerio; Carlos Licona, Juan; Villa Zegarra, Boris Eduardo; Guedes, Marcelino Carneiro; Ceron, Carlos; Thomas, Raquel; Milliken, William; Campelo, Wegliane; Albuquerque, Bianca Weiss; Klitgaard, Bente; Tello, J. Sebastian; Fuentes Claros, Alfredo; Rivas-Torres, Gonzalo; Fernando Phillips, Juan; von Hildebrand, Patricio; Gonzales, Therany; Vela, Cesar I. A.; Hoffman, Bruce; Flores, Bernardo Monteiro; Pombo, Maihyra Marina; Rocha, Maira; Holmgren, Milena; Cano, Angela; Umana, Maria Natalia; Fernanda Casas, Luisa; Balslev, Henrik; Urrego Giraldo, Ligia Estela; Bigorne, Remy; Oberdorff, Thierry; Maldonado-Ocampo, Javier A.; Ortega, Hernan; Hidalgo, Max; Martens, Koen; Torrente-Vilara, Gislene; Zuanon, Jansen; Acosta, Astrid; Agudelo, Edwin; Barrera Maure, Soraya; Bastos, Douglas A.; Bogota Gregory, Juan; Cabeceira, Fernando G.; Canto, Andre L. C.; Carvajal-Vallejos, Fernando M.; Carvalho, Lucelia N.; Cella-Ribeiro, Ariana; Covain, Raphael; Dias, Murilo S.; Donascimiento, Carlos; Doria, Carolina R. C.; Duarte, Cleber; Ferreira, Efrem J. G.; Galuch, Andre V.; Giarrizzo, Tommaso; Leitao, Rafael P.; Lundberg, John G.; Maldonado, Mabel; Mojica, Jose I.; Montag, Luciano F. A.; Ohara, William; Pires, Tiago H. S.; Pouilly, Marc; Prada-Pedreros, Saul; de Queiroz, Luiz J.; Py-Daniel, Lucia Rapp; Ribeiro, Frank R. V.; Herrera, Raul Rios; dos Anjos, Marcelo Rodrigues; Lourenco, Igor Hister; Sarmiento, Jaime; Sousa, Leandro M.; Stegmann, Lis F.; Valdiviezo-Rivera, Jonathan; Villa, Francisco; Yunoki, Takayuki; Tedesco, Pablo A.
  作者单位：Mississippi State University; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Universite Federale Toulouse Midi-Pyrenees (ComUE); Institut National Polytechnique de Toulouse; Institut de Recherche pour le Developpement (IRD); Mississippi State University; Naturalis Biodiversity Center; Utrecht University; Institute Nacional de Pesquisas da Amazonia; Helmholtz Association; Karlsruhe Institute of Technology; Institute Nacional de Pesquisas da Amazonia; Universidade Federal Rural da Amazonia (UFRA); Museu Paraense Emilio Goeldi; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Roraima; Universidad de Las Americas - Ecuador; University of Leeds; Field Museum of Natural History (Chicago); Universidade Estadual de Campinas; Universidade de Sao Paulo; Instituto Nacional de Pesquisas Espaciais (INPE); Universidade Federal do Rio Grande do Norte; University of Stirling; Universidad Nacional de San Antonio Abad del Cusco; Universidade Federal de Rondonia; Universidade Federal de Rondonia; State University System of Florida; University of Florida; State University System of Florida; University of Florida; James Cook University; James Cook University; University of St Andrews; University of Exeter; Universidade do Estado de Mato Grosso; Instituto Tecnologico Vale Desenvolvimento Sustentavel; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Genetic Resources & Biotechnology; Universidade Federal do Para; Universidade Federal do Para; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Amazonia Oriental; Universidad de los Andes (Colombia); University of Birmingham; Institute Nacional de Pesquisas da Amazonia; University of Amsterdam; Fundacao Universidade Federal do Amapa; United States Department of the Interior; US National Park Service; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; University of Gothenburg; Institute Nacional de Pesquisas da Amazonia; Centro Universitario do Estado do Para (CESUPA); Universidade Federal do Para; Institute Nacional de Pesquisas da Amazonia; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); Universidad Central del Ecuador; Royal Botanic Gardens, Kew; Royal Botanic Gardens, Kew; Missouri Botanical Gardens; Universidad Mayor de San Andres; Universidad San Francisco de Quito; State University System of Florida; University of Florida; Universidad Nacional de San Antonio Abad del Cusco; Universidade Federal de Santa Catarina (UFSC); Wageningen University & Research; University of Cambridge; University of Michigan System; University of Michigan; Aarhus University; Universidad Nacional de Colombia; Universidad Nacional Mayor de San Marcos; Royal Belgian Institute of Natural Sciences; Universidade Federal de Sao Paulo (UNIFESP); Universidade Santa Cecilia; Universidad Mayor de San Andres; La Coleccion Boliviana de Fauna; Universidade Federal de Mato Grosso; Universidade de Cuiaba; Universidade Federal do Oeste do Para; Universidad Mayor de San Simon; Universidade Federal de Mato Grosso; Universidade de Brasilia; Universidad de Antioquia; Universidade Federal de Rondonia; Universidade Federal do Para; Universidade Federal de Minas Gerais; Drexel University; Drexel University; Universidade Federal do Para; Universidade Federal de Rondonia; Museum National d'Histoire Naturelle (MNHN); Sorbonne Universite; Institut de Recherche pour le Developpement (IRD); Universite de Caen Normandie; Pontificia Universidad Javeriana; University of Groningen; Universidade Federal de Amazonas; Universidade Federal do Para; Universidad del Tolima
  摘要：Unlike most rivers globally, nearly all lowland Amazonian rivers have unregulated flow, supporting seasonally flooded floodplain forests. Floodplain forests harbor a unique tree species assemblage adapted to flooding and specialized fauna, including fruit-eating fish that migrate seasonally into floodplains, favoring expansive floodplain areas. Frugivorous fish are forest-dependent fauna critical to forest regeneration via seed dispersal and support commercial and artisanal fisheries. We imple...
• Metabolic enhancement contributed by horizontal gene transfer is essential for dietary specialization in leaf beetles AI翻译
  作者：Zhang, Yuxin; Tu, Chengjie; Bai, Jianyang; Li, Xiayu; Sun, Ziyue; Xu, Letian
  作者单位：Hubei University; Anhui Agricultural University
  摘要：Horizontal gene transfer (HGT) from bacteria to insects is widely reported and often associated with the adaptation and diversification of insects. However, compelling evidence demonstrating how HGT- conferred metabolic adjustments enable species to adapt to surrounding environment remains scarce. Dietary specialization is an important ecological strategy adopted by animals to reduce inter- and intraspecific competition for limited resources. Adults of the leaf beetle Plagiodera versicolora (C...
• Ectopic transcription due to inherited histone methylation may interfere with the ongoing function of differentiated neurons AI翻译
  作者：Rodriguez, Juan D.; Reeves, Monica N.; Chavez, Sindy R.; Wang, Hsiao- Lin V.; Chavez, Jaely Z.; Rastogi, Rhea; Sun, Liyang I.; Roberson, Mackenzie S.; Preston, Elicia A.; Massenburg, Zaynab; Cruz, Kiani N.; Chadha, Madhav S.; Hill, Emily J.; Soares, Miguel L.; Corces, Victor G.; Carpenter, Brandon S.; Schmeichel, Karen L.; Murray, John I.; Katz, David J.
  作者单位：Emory University; Emory University; University System of Georgia; Kennesaw State University; University of Pennsylvania
  摘要：How mutations in histone modifying enzymes lead to neurodevelopmental defects is unknown. To address this question, we took advantage of the invariant embryonic lineage and adult nervous system in Caenorhabditis elegans to investigate a double mutant between spr-5/Lsd1/Kdm1a (H3K4me1/2 demethylase) and met-2/Setdb1/Kmt1e (H3K9 methyltransferase). We demonstrate that spr-5; met-2 double mutant worms have a severe chemotaxis defect caused by the ectopic expression of germline genes in somatic ti...
• Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain AI翻译
  作者：Gan, Peiheng; Zhou, Xinyi; Shah, Akansha M.; Bezprozvannaya, Svetlana; Chen, Kenian; Ding, Qianqian; Li, Hui; Xu, Lin; Liu, Ning; Olson, Eric N.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Differentiation of smooth muscle cells (SMCs) is driven by the activation of a set of genes controlled by serum response factor (SRF), a ubiquitous transcription factor with limited intrinsic transcriptional activity. Myocardin (MYOCD) is a strong transcriptional coactivator that orchestrates smooth muscle differentiation through its association with SRF. MYOCD forms nuclear condensates via its intrinsically disordered transcription activation domain (TAD), whereas SRF is diffusely distributed...
• Amplification of particle collision through contact electrification in isotropic turbulence AI翻译
  作者：Johnson, Danielle R.; Bocanski, Adam; Diorio, Emily M.; Chen, James; Meng, Hui
  作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY
  摘要：Recent discovery of extreme clustering of inertial particles in isotropic turbulent flow suggests a hidden mechanism of particle-particle interaction at sub-Kolmogorov separations unexplained by hydrodynamic interaction. The near-contact radial distribution function (RDF) reaches O(104), resulting in a collision kernel four orders larger than direct numerical simulation predictions. Statistical stationarity is lost in the particle-laden turbulence, suggesting the particles experience a nonequi...