Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Communication increases cooperation among students in a coordination game AI翻译
  作者：Hallers-Haalboom, Elizabeth T.; De Jaegher, Kris J. M.; Sterck, Elisabeth H. M.; Brosnan, Sarah F.; Vermande, Marjolijn M.
  作者单位：Tilburg University; Utrecht University; Utrecht University; University System of Georgia; Georgia State University; University System of Georgia; Georgia State University; Utrecht University
  摘要：Cooperation often requires individuals to balance personal risk with mutual gain. The Stag Hunt game provides a well- established paradigm for studying such decision- making. Prior research suggested that verbal communication about the game correlated with participants finding the optimal coordinated solution, but these studies either did not manipulate communication directly or informed participants of the payoff structure in advance. This study examined whether communication improves coopera...
• Generative AI without guardrails can harm learning: Evidence from high school mathematics (vol 122, e2422633122, 2025) AI翻译
  作者：Bastani, Hamsa; Bastani, Osbert; Sungu, Alp; Ge, Haosen; Kabakci, Ozge; Mariman, Rei
  作者单位：University of Pennsylvania; University of Pennsylvania
• Identifying fish populations prone to abrupt shifts via dynamical footprint analysis AI翻译
  作者：Cano, Alejandro V.; Jensen, Olaf P.; Dakos, Vasilis
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; University of Wisconsin System; University of Wisconsin Madison
  摘要：Fish population biomass fluctuates through time in ways that may be either gradual or abrupt. While abrupt shifts in fish population productivity have been shown to be common, they are rarely integrated into stock assessment or fishery management, in part because of the difficulty of predicting when abrupt shifts may occur and which stocks are prone to such shifts. In this study, we address the latter challenge by designing a mechanism-agnostic context-specific approach that is based on exploi...
• Future winters promise less snow, more rain. Nobody's prepared AI翻译
  作者：McDermott, Amy
• Hippocampal mismatch signals are based on episodic memories and not schematic knowledge AI翻译
  作者：Varga, Dominika K.; Raykov, Petar P.; Jefferies, Elizabeth; Ben-Yakov, Aya; Bird, Chris M.
  作者单位：University of Sussex; University of Sussex; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of York - UK; Hebrew University of Jerusalem
  摘要：Prediction errors drive learning by signaling mismatches between expectations and reality, but the neural systems supporting these computations remain debated. The hippocampus is implicated in mismatch detection, yet it is not known whether it signals mismatches with episodic memories or generalized knowledge. Across three functional Magnetic Resonance Imaging (fMRI) experiments, we show that the hippocampus selectively responds to mismatches with episodic memories of specific events. In contr...
• The 2025 Mw7.7 Mandalay, Myanmar, earthquake reveals a complex earthquake cycle with clustering and variable segmentation on the Sagaing Fault AI翻译
  作者：Antoine, Solene L.; Shrestha, Rajani; Milliner, Chris; Im, Kyungjae; Rollins, Chris; Wang, Kang; Chen, Kejie; Avouac, Jean- Philippe
  作者单位：California Institute of Technology; Southern University of Science & Technology
  摘要：We use remote sensing observations to document surface deformation caused by the 2025 M(w)7.7 Mandalay earthquake. This event is a unique case of an extremely long (similar to 510 km) and sustained supershear rupture probably favored by the rather smooth and continuous geometry of this section of the structurally mature Sagaing Fault. The seismic rupture involved the locked portion of the fault over its entire depth extent (0 to 13 km) with a remarkably uniform slip distribution that averages ...
• Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases AI翻译
  作者：Davidi, Amit Fruitman; Shirenova, Sophie; Michaelovich, Dolev; Benedetti, Giulio; Shtrasberg, Hadar; Shoval, Irit; Hauschner, Hagit; Oz, Gal; Vardy, Karin; Hirsh, Tamir; Madar, Ravit; Stern, Edward A.; Rosenmann, Hanna; Biragyn, Arya; Okun, Eitan
  作者单位：Bar Ilan University; Bar Ilan University; Bar Ilan University; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hadassah University Hospital; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
  摘要：The meninges serve as a critical interface between the peripheral immune system and the central nervous system, playing a crucial role in maintaining parenchymal homeostasis. Neurodegenerative disorders, such as amyloidosis and tauopathies, are marked by the accumulation of extracellular neurotoxic amyloid-f3 (Af3) plaques and intracellular tau tangles, respectively, leading to neuronal cell death and cognitive decline. The role of the adaptive immune response in these pathologies remains unde...
• Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors AI翻译
  作者：Heiser, Florian; Biedermann, Johann; Kuru, Ece; Plested, Andrew J. R.; Sun, Han
  作者单位：Humboldt University of Berlin; Leibniz Association; Leibniz Forschungsinstitut furr Molekulare Pharmakologie (FMP); Technical University of Berlin; Technische Universitat Dresden; Humboldt University of Berlin
  摘要：GluA2 is a key subunit of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) ion channels that is abundantly expressed in the vertebrate brain. Posttranscriptional Q/R editing of GluA2 renders AMPARs nearly impermeable to calcium ions, which is crucial for their normal function. Although previous studies have characterized conductivity and selectivity differences between edited and unedited GluA2 variants and heteromeric receptors incorporating GluA2, the consequences of por...
• The fetal hydrops-associated single-residue mutation L322P disrupts mechanical but not chemical activation of the PIEZO1 ion channel AI翻译
  作者：Jiang, Jinghui; Guo, Wei; Chen, Xudong; He, Qijing; Wang, Yubo; Zhu, Xiaohui; Yan, Liying; Qiao, Jie; Xiao, Bailong
  作者单位：Tsinghua University
  摘要：The mechanically activated PIEZO1ion channel is genetically linked to numerous physiological and pathophysiological processes. For example, deleting PIEZO1 in mice leads to defective lymphatic vessel development, while nonsense mutations in humans are associated with autosomal recessive generalized lymphatic dysplasia (GLD) and nonimmune hydrops fetalis. However, it remains unclear whether PIEZO1-dependent biological processes are directly mediated by its intrinsic mechanosensitivity. Here, we...
• Three decades of declines restructure butterfly communities in the Midwestern United States AI翻译
  作者：Leuenberger, Wendy; Doser, Jeffrey W.; Belitz, Michael W.; Ries, Leslie; Haddad, Nick M.; Thogmartin, Wayne E.; Zipkin, Elise F.
  作者单位：Michigan State University; Michigan State University; North Carolina State University; Georgetown University; Michigan State University; United States Department of the Interior; United States Geological Survey
  摘要：Insects are declining worldwide. These declines have been documented across taxonomic groups and are worrisome given ecosystem services provided by insects. Long-term data have illuminated butterfly declines across geographic regions. However, critical questions remain on how butterfly declines are distributed across species and functional groups, limiting effective conservation. Here, we show unprecedented changes in butterfly biodiversity resulting from 32 y of species levels declines throug...