Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Identification of a protective antigen reveals the trade- off between iron acquisition and antigen exposure in a global fungal pathogen AI翻译
  作者：Li, Yeqi; Pham, Tuyetnhu; Hipsher, Kenton; Lee, Christopher W. J.; Jiao, Jie; Penninger, Josef M.; Kronstad, James W.; Fan, Yumeng; Zhao, Youbao; Ambati, Suresh; Meagher, Richard B.; Xie, Xiaofeng; Lin, Xiaorong
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of British Columbia; University of British Columbia; Medical University of Vienna; Helmholtz Association; Helmholtz-Center for Infection Research; Austrian Academy of Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); University System of Georgia; University of Georgia
  摘要：Systemic infections caused by Cryptococcus claim over 161,000 lives annually, with global mortality rate close to 70% despite antifungal therapies. Currently, no vaccine is available. To develop an effective multivalent vaccine against this free- living oppor-tunistic eukaryotic pathogen, it is critical to identify protective antigens. We previously discovered ZNF2oe strains elicit protective host immune responses and increase the abundance of antigens present in the capsule, which is required...
• Identifying new classes of financial price jumps with wavelets AI翻译
  作者：Aubrun, Cecilia; Morel, Rudy; Benzaquen, Michael; Bouchaud, Jean-Philippe
  作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Simons Foundation; Flatiron Institute
  摘要：We introduce an unsupervised classification framework that leverages a multiscale wavelet representation of time-series and apply it to stock price jumps. In line with previous work, we recover the fact that time-asymmetry of volatility is the major feature that separates exogenous, news-induced jumps from endogenously generated jumps. Local mean-reversion and trend are found to be two additional key features, allowing us to identify new classes of jumps. Using our wavelet-based representation...
• A pentatomomorpha- specific salivary protein activates plant immunity and is critical for insect feeding AI翻译
  作者：Hu, Biao; Feng, Xiuli; Xu, Manru; Huang, Yue; Guo, Chunyun; Yuan, Ruikun; Li, Yiyuan; Wei, Zhongyan; Chen, Jianping; Sun, Zongtao
  作者单位：Ningbo University
  摘要：The stinkbug Riptortus pedestris, notorious for inducing soybean staygreen-like syndrome, employs a range of salivary proteins to manipulate the host plant for its benefit. Here, we show that RpSP1, a salivary protein specific to Pentatomomorpha, triggers plant defense responses in multiple plant species. RpSP1 interacts with and stabilizes a HSP40 family protein GmSPIP1 and is dependent on GmSPIP1 to induce cell death. We show that a critical 22-amino acid peptide within RpSP1 acts as an intr...
• How towns can adapt to fire as bigger burns loom AI翻译
  作者：Mcdermott, Amy
• Iron limitation triggers roseoceramide biosynthesis and membrane remodeling in marine roseobacter AI翻译
  作者：Ganley, Jack G.; Seyedsayamdost, Mohammad R.
  作者单位：Princeton University; Princeton University
  摘要：Chemical communication between marine bacteria and their algal hosts drives population dynamics and ultimately determines the fate of major biogeochemical cycles in the ocean. To gain deeper insights into this small molecule exchange, we screened niche- specific metabolites as potential modulators of the secondary metabolome of the roseobacter, Roseovarius tolerans. Metabolomic analysis led to the identification of a group of cryptic lipids that we have termed roseoceramides. The roseoceramide...
• A tough soft-hard interface in the human knee joint driven by multiscale toughening mechanisms AI翻译
  作者：Li, Wenyue; Wang, Xiaozhao; Mao, Renwei; Li, Dong; Meng, Hongxu; Zhang, Ru; Fang, Jinghua; Kang, Zhengzhong; Wu, Boxuan; Ma, Weiwei; Yao, Xudong; Xie, Chang; Li, Rui; Wang, Jin; Chen, Xiao; Pan, Xihao; Chen, Weiqiu; Duan, Wangping; Gao, Huajian; Ouyang, Hongwei
  作者单位：Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Nanyang Technological University; Zhejiang University; Zhejiang University; Shanxi Medical University; Tsinghua University
  摘要：Joining heterogeneous materials in engineered structures remains a significant challenge due to stress concentration at interfaces, which often leads to unexpected failures. Investigating the complex, multiscale- graded structures found in animal tissue provides valuable insights that can help address this challenge. The human meniscus root-bone interface is an exemplary model, renowned for its exceptional fatigue resistance, toughness, and interfacial adhesion properties throughout its lifesp...
• Widespread soil bacterium that oxidizes atmospheric methane (vol 116, pg 8515, 2019) AI翻译
  作者：Tveit, Alexander T.; Hestnes, Anne Grethe; Robinson, Serina L.; Schintlmeister, Arno; Dedysh, Svetlana N.; Jehmlich, Nico; von Bergen, Martin; Herbold, Craig; Wagner, Michael; Richter, Andreas; Svenning, Mette M.
• The Aedes aegypti mosquito evolves two types of prophenoloxidases with diversified functions AI翻译
  作者：Zhu, Xiaojing; Zhang, Lei; Jiang, Linlong; Chen, Huaqing; Tang, Yu; Yang, Xiaoyun; Bao, Pengkun; Liao, Chenghong; Li, Jianyong; Vavricka, Christopher J.; Ren, Delin; Chen, Zhaohui; Guo, Yingying; Han, Qian
  作者单位：Hainan University; Hainan University; Hainan Vocational University of Science & Technology; Virginia Polytechnic Institute & State University; Tokyo University of Agriculture & Technology
  摘要：Insect phenoloxidase, presented as an inactive precursor prophenoloxidase (PPO) in hemolymph, catalyzes melanin formation, which is involved in wound healing, pathogen killing, reversible oxygen collection during insect respiration, and cuticle and eggshell formation. Mosquitoes possess 9 to 16 PPO members across different genera, a num-ber that is more than that found in other dipteran insects. However, the reasons for the redundancy of these PPOs and whether they have distinct biochemical pr...
• Motor neuron disease, TDP- 43 pathology, and memory deficits in mice expressing ALS-FTD- linked UBQLN2 mutations (vol 113, pg E7580, 2016) AI翻译
  作者：Le, Nhat T. T.; Chang, Lydia; Kovlyagina, Irina; Georgiou, Polymnia; Safren, Nathaniel; Braunstein, Kerstin E.; Kvarta, Mark D.; Van Dyke, Adam M.; LeGates, Tara A.; Philips, Thomas; Morrison, Brett M.; Thompson, Scott M.; Puche, Adam C.; Gould, Todd D.; Rothstein, Jeffrey D.; Wong, Philip C.; Monteiro, Mervyn J.
• Increasing pesticide diversity impairs soil microbial functions AI翻译
  作者：Ni, Bang; Xiao, Lu; Lin, Da; Zhang, Tian- Lun; Zhang, Qi; Liu, Yanjie; Chen, Quan; Zhu, Dong; Qian, Haifeng; Rillig, Matthias C.; Zhu, Yong- Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shaoxing University; Kunming University of Science & Technology; Zhejiang University of Technology; Free University of Berlin; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS
  摘要：Pesticide application is essential for stabilizing agricultural production. However, the effects of increasing pesticide diversity on soil microbial functions remain unclear, particularly under varying nitrogen (N) fertilizer management practices. In this study, we investigated the stochasticity of soil microbes and multitrophic networks through amplicon sequencing, assessed soil community functions related to carbon (C), N, phosphorus (P), and sulfur (S) cycling, and characterized the dominan...