Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Structures of Chaetomium thermophilum TOM complexes with bound preproteins AI翻译
  作者：Agip, Ahmed-Noor A.; Ornelas, Pamela; Yang, Tzu-Jing; Uboldi, Ermanno; Haeder, Sabine; McDowell, Melanie A.; Kuehlbrandt, -Werner
  作者单位：Max Planck Society; Max Planck Society
  摘要：Mitochondria import most of their proteins from the cytoplasm through the TOM complex. Preproteins containing targeting signals are recognized by the TOM receptor subunits and translocated by Tom40 across the outer mitochondrial membrane. We present four structures of the preprotein- bound and preprotein- free TOM core and holo complexes from the thermophilic fungus Chaetomium thermophilum, obtained by single- particle electron cryomicroscopy. Our structures reveal the symmetric arrangement of...
• Surface tension between coexisting phases of active Brownian particles AI翻译
  作者：Li, Longfei; Sun, Zihao; Yang, Mingcheng
  作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The confliction between the stable interface in phase-separated active Brownian particles and its negative surface tension, obtained mechanically via the active pressure, has sparked considerable debate about the formula of active surface tension. Based on the intrinsic pressure of active system, we here derive a mechanical expression of active surface tension by calculating the work required to create a differential interface area, while remaining the interfacial profiles of intensive quantit...
• Explaining and predicting the Southern Hemisphere eddy-driven jet AI翻译
  作者：Mindlin, Julia; Shepherd, Theodore G.; Osma, Marisol; Vera, Carolina S.; Kretschmer, Marlene; Marengo, Jose A.
  作者单位：University of Reading; Helmholtz Association; Research Center Julich; University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
  摘要：The summertime eddy-driven jet (EDJ) in the Southern Hemisphere is a critical mediator between regional climate and large-scale phenomena, guiding synoptic systems that shape weather patterns. Uncertainties in global climate models (GCMs)-particularly in projecting changes in remote drivers like tropical warming, stratospheric polar vortex strengthening, and asymmetric tropical Pacific warming-hinder predictions of EDJ trends and associated regional outcomes. In this study, we develop a causal...
• In vivo generation of CAR macrophages via the enucleated mesenchymal stem cell delivery system for glioblastoma therapy AI翻译
  作者：Zhou, Lei; Song, Qingying; Zhang, Xin; Cao, Mengnian; Xue, Dayu; Sun, Yiwen; Mao, Meihua; Li, Xinling; Zhang, Zhenzhong; Liu, Junjie; Shi, Jinjin
  作者单位：Zhengzhou University; Zhengzhou University
  摘要：Glioblastoma multiforme (GBM) is one of the most aggressive intracranial tumors for which there is no effective treatment. Chimeric antigen receptor macrophage (CAR-M) therapies have demonstrated impressive therapeutic efficacy in solid tumors; however, the cost and rigor associated with manufacturing engineered macrophages ex vivo can be prohibitive. Here, we utilized enucleated mesenchymal stem cells (MSCs) as vehicles for the targeted delivery of CAR-encoding plasmid to reprogram glioma-ass...
• An aminosterol breaks the autocatalytic cycle of Aβ42 aggregation and protects cell membranes from its soluble aggregates AI翻译
  作者：Fallot, Lucas B.; Pinc, Johnathan R.; Buselmeier, Joseph E.; Palchak, Julia C.; Shroff, Supria S.; Zang, Kaitlyn; Rinauro, Dillon J.; Bacon, Kate M.; Nguyen, Michael; Schleck, Mary Claire; Cornell, Alyssa R.; Oshidar, Alexandra; Darrell, Donald J.; Gabriel, Justus M.; Wright, Aidan K.; Sasser, Liam R.; Kreiser, Ryan P.; Burpo, F. John; Santambrogio, Alessia; Xu, Peifeng; Kubiak II, Robert W.; Loverde, Joseph; A.Jaffett, Victor; Toole, Justin R.; Barbut, Denise; Zasloff, Michael; Chiti, Fabrizio; Dear, AlexanderJ.; Vendruscolo, Michele; Limbocker, Ryan
  作者单位：United States Military Academy; United States Department of Defense; United States Army; United States Military Academy; United States Department of Defense; United States Army; University of Cambridge; Georgetown University; University of Florence; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Aberrant aggregates of the 42-residue form of the amyloid-f3 peptide (Af342) are cytotoxic in Alzheimer's disease (AD). Cost-effective and chronically safe disease-modifying therapeutics are needed to address the AD medical emergency worldwide. To increase our understanding of the mechanisms of Af342-induced cytotoxicity and to investigate clinically relevant aminosterols, we study the impact of claramine on the aggregation kinetics and properties of Af342 aggregates, as well as the ability of...
• Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial- to- hematopoietic transition (vol 110, pg E141, 2012) AI翻译
  作者：Kim, Peter Geon; Albacker, Colleen E.; Lu, Yi-fen; Jang, Il-ho; Lim, Yoowon; Heffner, Garrett C.; Arora, Natasha; Bowman, Teresa V.; Lin, Michelle I.; Lensch, M. William; De Los Angeles, Alejandro; Zon, Leonard I.; Loewer, Sabine; Daley, George Q.
• Onset of extensive human fire use 50,000 y ago AI翻译
  作者：Jiang, Shoushu; Zhao, Debo; Kaboth-Bahr, Stefanie; Beaufort, Luc; Tu, Hua; Lu, Zhengyao; Cheng, Zhongjing; Zhang, Shanjia; Zhong, Yi; Hao, Xiudong; Pei, Wenqiang; Cui, Guangqiang; Yang, Yifei; Lin, Anni; Huang, Jie; Wan, Shiming
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Free University of Berlin; Aix-Marseille Universite; Institut de Recherche pour le Developpement (IRD); INRAE; Centre National de la Recherche Scientifique (CNRS); Shantou University; Lund University; Tongji University; Lanzhou University; Southern University of Science & Technology; Nanning Normal University; China West Normal University; Chinese Academy of Sciences; Institute of Oceanology, CAS
  摘要：Fire is a pivotal aspect of human involvement in the carbon cycle. However, the precise timing of the large-scale human fire use remains uncertain. Here, we report a pyrogenic carbon record of East Asian fire history over the past 300,000 y from the East China Sea. This record suggests a rapid increase in fire activity since approximately 50,000 y ago, indicating a decoupling from the monsoon climate, and this pattern is consistent with fire histories in Europe, Southeast Asia, and Papua New G...
• Disentangling temperature and Reynolds number effects in quantum turbulence AI翻译
  作者：Polanco, Juan Ignacio; Roche, Philippe-E.; Danaila, Luminita; Leveque, Emmanuel
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Ecole Centrale de Lyon; Institut National des Sciences Appliquees de Lyon - INSA Lyon; Universite Claude Bernard Lyon 1; Universite Jean Monnet; Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Universite de Rouen Normandie
  摘要：The interplay between viscous and frictional dissipation is key to understanding quantum turbulence dynamics in superfluid 4He. Based on a coarse-grained two-fluid description, an original scale-by-scale energy budget that identifies each scale's contribution to energy dissipation is derived. Using the Hall-Vinen-Bekharevich-Khalatnikov (HVBK) model to further characterize mutual friction, direct numerical simulations at temperatures 1.44 K less than or similar to T less than or similar to 2.1...
• Building confidence in models for complex barrier systems for radionuclides AI翻译
  作者：Sarsenbayev, Dauren; Tournassat, Christophe; Steefel, Carl I.; Wainwright, Haruko M.
  作者单位：Massachusetts Institute of Technology (MIT); United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Orleans; Bureau de Recherches Geologiques et Minieres (BRGM); Massachusetts Institute of Technology (MIT)
  摘要：The modeling and simulation of the Cement-clay Interaction-Diffusion field (CI-D) experiment at the Mont Terri site in Switzerland presented here demonstrates that it is possible to capture the multiscale physical and chemical features of natural and engineered barrier systems for radionuclides. The simulations are successfully carried out with the newly developed CrunchODiTi high-performance computing software that accounts for multiple continua, including a continuum representing the electri...
• Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer AI翻译
  作者：Sushentsev, Nikita; Hamm, Gregory; Manavaki, Roido; McLean, Mary A.; Birchall, Jonathan; Soloviev, Dmitry; Lewis, David Y.; Aloj, Luigi; Flint, Lucy; Zakirov, Aleksandr; Mills, Ian G.; Gnanapragasam, Vincent J.; Warren, Anne Y.; Barry, Simon T.; Goodwin, Richard J. A.; Gallagher, Ferdia A.; Barrett, Tristan
  作者单位：Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Cambridge; AstraZeneca; University of Glasgow; University of Cambridge; University of Oxford; Queens University Belfast; Aarhus University; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; AstraZeneca
  摘要：Cribriform prostate cancer (crPCa) is associated with poor clinical outcomes, yet its accurate detection remains challenging due to the poor sensitivity of standard- of- care diagnostic tools. Here, we use untargeted spatial metabolomics to identify fatty acid biosynthesis as a key metabolic pathway enriched in crPCa epithelium. We also show that imaging tumor copy differentiates cribriform from noncribriform intermediate- risk prostate cancers in two prospective patient cohorts. These finding...