Proceedings of the National Academy of Sciences of the United States of America

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• Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism AI翻译
  作者：Zhu, Man; Wang, Ru; Yi, Wei; Wu, Beiyi; Deng, Zhizhong; Zhang, Zheng; Wang, Chen; Zhang, Dingkun; Zhang, Tongtong; Wen, Xue
  作者单位：Sichuan University; University of Electronic Science & Technology of China; Sichuan University; Southwest Jiaotong University; Soochow University - China; Sichuan University; Southwest Jiaotong University
  摘要：Bisphenol A (BPA) substitutes are widely used as food contact materials and consumer products, while the effects of pathophysiologically relevant concentrations of BPA substitutes on aging remain unclear. In this study, we used Caenorhabditis elegans (C. elegans) to investigate the effects of five BPA substitutes [bisphenol S (BPS), bisphenol B, bisphenol F (BPF), tetramethyl BPF, and 4,4 '-(Perfluoropropane-2,2-diyl)diphenol] at pathophysiologically relevant exposure levels during aging and e...
• CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis AI翻译
  作者：Lamperis, Sophia M.; Mcmahon, Kaylin M.; Calvert, Andrea E.; Rink, Jonathan S.; Vasan, Karthik; Pandkar, Madhura R.; Crentsil, Eliana U.; Chalmers, Zachary R.; Mcdonald, Natalie R.; Kosmala, Cameron J.; Bonini, Marcelo G.; Matei, Daniela; Gordon, Leo I.; Chandel, Navdeep S.; Thaxton, C. Shad
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center; Northwestern University; Feinberg School of Medicine; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center
  摘要：Ferroptosis is a cell death mechanism distinguished by its dependence on iron-mediated lipid oxidation. Cancer cells highly resistant to conventional therapies often demonstrate lipid metabolic and redox vulnerabilities that sensitize them to cell death by ferroptosis. These include a unique dependency on the lipid antioxidant selenoenzyme, glutathione peroxidase 4 (GPx4), that acts as a ferroptosis inhibitor. Synthetic high-density lipoprotein-like nanoparticle (HDL NP) targets the high-affin...
• Physical activity stimulates clock neurons of the day-active rodent Arvicanthis ansorgei AI翻译
  作者：Caputo, Rosanna; Schoonderwoerd, Robin A.; Ramkisoensing, Ashna; Janse, Jan A. M.; van Diepen, Hester C.; Raison, Sylvie; Pevet, Paul; Sage-Ciocca, Dominique; Deboer, Tom; Challet, Etienne; Meijer, Johanna H.
  作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS)
  摘要：Our biological clock, located in the suprachiasmatic nucleus (SCN), controls behavioral activity rhythms by producing circadian rhythms in SCN electrical activity. Behavioral studies in humans suggest that the clock is sensitive not only to light but also to physical activity. Here, we examined the effect of physical activity on the brain's clock in the diurnal rodent, Arvicanthis ansorgei. We found that the electrical activity of SCN neurons in vitro is high during the day and low during the ...
• Two endogenous Dictyostelium discoideum chemorepellents use different mechanisms to induce repulsion AI翻译
  作者：El-Sobky, Mohanad H.; Rijal, Ramesh; Gomer, Richard H.
  作者单位：Texas A&M University System; Texas A&M University College Station; University of Southern Mississippi
  摘要：The directed movement of eukaryotic cells is critical for processes such as development and immune responses. While much is known about chemoattraction, much less is known about chemorepulsion. The eukaryotic amoeba Dictyostelium discoideum secretes a 60 kDa chemorepellent protein called AprA to cause cells at the edge of a colony to move away from the colony. In addition to AprA, cells secrete a <10 kDa chemorepellent. Here, we show that the <10 kDa chemorepellent is a polymer of phosphates (...
• Multiparametric functional characterization of individual lipid nanoparticles using surface- sensitive light- scattering microscopy AI翻译
  作者：Sjoeberg, Mattias; Olsen, Erik; Mapar, Mokhtar; Parkkila, Petteri; Niederkofler, Simon; Mohammadi, Sara; Jing, Yujia; Emilsson, Gustav; Lindfors, Lennart; Agnarsson, Bjorn; Hook, Fredrik
  作者单位：Chalmers University of Technology; AstraZeneca
  摘要：The most efficient lipid nanoparticles (LNPs) for gene therapeutics rely on specific lipids that protect the oligonucleotide cargo and aid cellular uptake and subsequent endosomal escape. Yet, the efficacy of current state-of-the-art LNP formulations remains low, a few percent at best. A deeper understanding of how LNP cargo, lipid composition, stoichiometry, size, structure, and pH-induced conformational changes influence their efficiency is therefore necessary for improved design. Given the ...
• Engineering spin coherence in core-shell diamond nanocrystals AI翻译
  作者：Zvi, Uri; Candido, Denis R.; Weiss, Adam M.; Jones, Aidan R.; Chen, Lingjie; Golovina, Iryna; Yu, Xiaofei; Wang, Stella; Talapin, Dmitri V.; Flatte, Michael E.; Esser, Aaron P.; Maurer, Peter C.
  作者单位：University of Chicago; University of Iowa; University of Chicago; University of Chicago; University of Pennsylvania; United States Department of Energy (DOE); Argonne National Laboratory; United States Department of Energy (DOE); Argonne National Laboratory; Eindhoven University of Technology
  摘要：Fluorescent diamond nanocrystals can host spin qubit sensors capable of probing the physical properties of biological systems with nanoscale spatial resolution. Sub-100 nm diamond nanosensors can readily be delivered into intact cells and even living organisms. However, applications beyond current proof-of-principle experiments require a substantial increase in sensitivity, which is limited by surface induced charge instability and electron-spin dephasing. In this work, we utilize engineered c...
• Starch-rich plant foods 780,000 y ago: Evidence from Acheulian percussive stone tools (vol 122, e2418661121, 2025) AI翻译
  作者：Ahituv, Hadar; Henry, Amanda G.; Melamed, Yoel; Goren-Inbar, Naama; Bakels, Corrie; Shumilovskikh, Lyudmila; Cabanes, Dan; Stone, Jeffery R.; Rowe, Walter F.; Alperson-Afil, Nira
• Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin AI翻译
  作者：Beccari, Melinda S.; Arnold-Garcia, Olatz; Baughn, Michael W.; Artates, Jonathan W.; McAlonis-Downes, Melissa; Lim, Jaisen; Leyva-Cazares, Dulce Fernanda; Rubio-Lara, Hugo Isaac; Ramirez-Rodriguez, Andrea; Bernal-Buenrostro, Carol N.; Murgia-Bay, Brian; Rangel, Carolina K.; Kim, Dong Hyun; Melamed, Ze'ev; Lutz, Cathleen M.; Lagier-Tourenne, Clotilde; Corbett, Kevin D.; Lopez-Erauskin, Jone; Cleveland, Don W.
  作者单位：University of California System; University of California San Diego; Instituto de Investigacion Sanitaria Biogipuzkoa; CIBERNED; Universidad Autonoma de Baja California; Hebrew University of Jerusalem; Jackson Laboratory; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); University of California System; University of California San Diego; Pfizer; Pfizer USA
  摘要：Stathmin-2 (also known as SCG10) is encoded by the STMN2 gene, whose mRNA is one of the most abundantly expressed in human motor neurons. In almost all instances of ALS and other TDP-43 proteinopathies, stathmin-2 encoding mRNAs are cryptically spliced and polyadenylated in motor neurons, a pathogenic consequence of nuclear loss of function of the RNA binding protein TDP-43. While stathmin-2 has been shown to enhance regeneration after axonal injury to axons of cultured motor neurons, here, we...
• Physical exercise activates a PVN-NAc oxytocin circuit to relieve stress- induced depressive- like behaviors AI翻译
  作者：Xia, Jie; Zou, Yong; Cui, Yuqing; Zhang, Sen; Huo, Konglin; Liu, Wenbin; Huang, Zhuochun; Zhang, Qiang; Qi, Zhengtang; Liu, Weina
  作者单位：Shanghai Jiao Tong University; East China Normal University; East China Normal University; East China Normal University; East China Normal University
  摘要：Physical exercise is known to reduce depression, but the underlying brain mechanisms remain unclear. Based on a chronic restraint stress model in mice, we showed that 4-wk treadmill exercise profoundly maintained normal neural activity in the nucleus accumbens (NAc), in association with the prevention of depressive-like behaviors. Microarray analysis conducted in the NAc revealed that the oxytocin (OT) receptor displayed the most significant differential expression, implying a crucial involvem...
• CaMK modulates sensory neural activity to control longevity and proteostasis AI翻译
  作者：Zhao, Ranran; Ge, Weiqi; Xue, Weikang; Deng, Zaidong; Liu, Jiaze; Wang, Kaiqi; Jin, Youngnam N.; Yu, Yanxun, V
  作者单位：Wuhan University; Wuhan University
  摘要：The impact of neural activity on aging and longevity remains poorly understood, with limited understanding of the specific neuron groups and molecular mechanisms that regulate lifespan. In this study, we uncover a correlation between human longevity and reduced CaMK4 expression in the frontal cortex. We further show that this link is conserved in Caenorhabditis elegans, where the loss of the homolog CMK-1 leads to increased longevity and enhanced proteostasis. These beneficial effects are prim...