Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Molecular contacts in self- assembling clusters of membrane proteins AI翻译
  作者：Mandala, Venkata Shiva; Fu, Ziao; Mackinnon, Roderick
  作者单位：Rockefeller University; Howard Hughes Medical Institute; Rockefeller University; Washington University (WUSTL)
  摘要：Motivated by recent data pointing to the existence of homo- oligomeric assemblies of membrane proteins called higher- order transient structures, and their apparent role in connecting components of membrane signal pathways, we examine here by cryoelectron microscopy some of the protein-protein interactions that occur in cluster formation. Metabotropic glutamate receptors and HCN ion channels inside clusters contact their neighbors through structured extracellular and intracellular domains, res...
• Testicular somatic and germ cell maturation during rhesus macaque development AI翻译
  作者：Sosa, Enrique; Wamaitha, Sissy E.; Hsu, Fei-man; Lara, Mary Jasmine D.; Oyama, Kiana; Custer, Maggie; Murphy, Melinda; Hennebold, Jon D.; Hwang, Young Sun; Clark, Amander T.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University
  摘要：The formation of bilateral testes in animals is critical for puberty, reproductive capacity, and testosterone production across the life course. In humans, testis development begins in embryonic life in the first trimester, with considerable effort focused on the cell and developmental events associated with testis cell specification, leaving limited knowledge on testicular organogenesis during the second and third trimesters. To fill this knowledge gap, we evaluated testicular cell maturation...
• Observation of the electric Breit-Rabi effect AI翻译
  作者：Wang, Shao-Zheng; Wang, Shou-Bo; Tao, Zhi-Jin; Xia, Tian; Lu, Zheng-Tian
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The response of an atom to external electric and magnetic fields can reveal fundamental atomic properties. It has long been verified that, in a static magnetic field, those atomic energy levels with hyperfine interactions shift according to the Breit-Rabi formula, which introduces nonlinear dependence on the magnetic field. On the other hand, the corresponding Breit-Rabi dependence on a static electric field has not been observed before due to a combination of experimental challenges. Here, we...
• Comparative evaluation of behavioral epidemic models using COVID-19 data AI翻译
  作者：Gozzi, Nicolo; Perra, Nicola; Vespignani, Alessandro
  作者单位：Northeastern University; University of London; Queen Mary University London; Alan Turing Institute
  摘要：Characterizing the feedback linking human behavior and the transmission of infectious diseases (i.e., behavioral changes) remains a significant challenge in computational and mathematical epidemiology. Existing behavioral epidemic models often lack real-world data calibration and cross-model performance evaluation in both retrospective analysis and forecasting. In this study, we systematically compare the performance of three mechanistic behavioral epidemic models across nine geographies and t...
• PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis AI翻译
  作者：Huang, Xin; Li, Fangxia; Liu, Lin; Li, Yanxia; Zhang, Mengmeng; Ma, Guoming; Gao, Ying; Shan, Bing; Liang, Xiaozhen; Yuan, Junying; Pan, Heling
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS
  摘要：Necroptosis and apoptosis are two alternatively regulated cell death pathways. Activation of RIPK1 upon engagement of TNFR1 by TNF alpha may promote necroptosis by interacting with RIPK3 or apoptosis by activating caspases. RIPK1 is extensively regulated by a variety of dynamic posttranslational modifications which control its kinase activity and formation of downstream complexes to mediate necroptosis and apoptosis. Here, we investigate the functional significance and mechanism by which PARP1...
• Hamiltonella symbionts benefit whitefly fertilization by regulating the maternal protein Tudor-mediated piRNA pathway AI翻译
  作者：Sun, Xiang; Li, Huan; Chen, Zhan- Bo; Liu, Bing- Qi; Li, Chu- Qiao; Zhao, Zheng- Yang; Li, Xing-Ye; Luan, Jun-Bo
  作者单位：Shenyang Agricultural University; Shenyang Agricultural University
  摘要：Although it is widely recognized that nutritional symbionts can manipulate host reproduction, the underlying molecular and cellular mechanisms are largely unclear. The facultative symbiont Hamiltonella in bacteriocyte induces female-biased sex ratio of whiteflies. Here, we demonstrate that a maternal gene tudor (tud) and its encoded protein have lower expression levels in ovaries of Hamiltonella-cured whiteflies. Tud family proteins can interlink the various stages of biosynthesis of PIWI-inte...
• TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin (112 , 1499-1504, 2015) AI翻译
  作者：Arseni, Lavinia; Lanzafame, Manuela; Compe, Emmanuel; Fortugno, Paola; Afonso-Barroso, Antonio; Peverali, Fiorenzo A.; Lehmann, Alan R.; Zambruno, Giovanna; Egly, Jean-Marc; Stefanini, Miria; Orioli, Donata
• Cochlear zinc signaling dysregulation is associated with noise-induced hearing loss, and zinc chelation enhances cochlear recovery (vol 121, e2310561121, 2024) AI翻译
  作者：Bizup, Brandon; Brutsaert, Sofie; Cunningham, Christopher L.; Thathiah, Amantha; Tzounopoulos, Thanos
• SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato AI翻译
  作者：He, Xiaoqing; Wu, Yi; Shu, Peng; Yin, Yanpeng; Deng, Heng; Ying, Shiyu; Wu, Mengbo; Zhao, Panpan; Huang, Tengbo; Pirrello, Julien; Zhang, Yang; Grierson, Don; Zhong, Zhenhui; Hong, Yiguo; Bouzayen, Mondher; Liu, Mingchun
  作者单位：Sichuan University; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Shenzhen University; University of Nottingham; University of Warwick; Hebei Agricultural University
  摘要：Improving fruit growth and quality without compromising yield is a highly sought-after goal in crop breeding. Here, we report that an EAR motif-containing transcription factor SlPLT6 controls the onset of fruit ripening and quality traits in tomato. SlPLT6 knockout caused precocious ripening initiation and enhanced fruit qualities without penalizing yield in two tomato cultivars. SlPLT6 represses genes involved in ripening initiation and major quality traits by directly binding to their promot...
• A proteomic signature of healthspan AI翻译
  作者：Kuo, Chia - Ling; Liu, Peiran; Drouard, Gabin; Vuoksimaa, Eero; Kaprio, Jaakko; Ollikainen, Miina; Chen, Zhiduo; Pilling, Luke C.; Atkins, Janice L.; Fortinsky, Richard H.; Kuchel, George A.; Diniz, Breno S.
  作者单位：University of Connecticut; University of Connecticut; University of Connecticut; University of Helsinki; University of Exeter; University of Connecticut
  摘要：The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability.Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of healthspan. We developed a proteomics-based signature of healthspan [healthspan proteomic score (HPS)] using proteomic data from the Olink Explore 3072 assay in the UK Biobank Pharma Proteomics Project (53,018 individuals and 2,920 proteins). A lower HPS was ...