Proceedings of the National Academy of Sciences of the United States of America

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• Genomic analysis of progenitors in viral infection implicates glucocorticoids as suppressors of plasmacytoid dendritic cell generation AI翻译
  作者：Jo, Yeara; Greene, Trever T.; Chiale, Carolina; Zhang, Kai; Fang, Ziyan; Dallari, Simone; Marooki, Nuha; Wang, Wei; Zuniga, Elina I.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Plasmacytoid Dendritic cells (pDCs) are the most potent producers of interferons, which are critical antiviral cytokines. pDC development is, however, compromised following a viral infection, and this phenomenon, as well as its relationship to conventional (c)DC development is still incompletely understood. By using lymphocytic choriomeningitis virus (LCMV) infection in mice as a model system, we observed that DC progenitors skewed away from pDC and toward cDC development during in vivo viral ...
• Distantly related bacteria share a rigid proteome allocation strategy with flexible enzyme kinetics AI翻译
  作者：Zhu, Manlu; Mori, Matteo; Hwa, Terence; Dai, Xiongfeng
  作者单位：Central China Normal University; University of California System; University of California San Diego
  摘要：Bacteria are known to allocate their proteomes according to how fast they grow, and the allocation strategies employed strongly affect bacterial adaptation to different environments. Much of what is currently known about proteome allocation is based on extensive studies of the model organism Escherichia coli. It is not clear how much of E. coli's proteome allocation strategy is applicable to other species, particularly since different species can grow at vastly different rates even in the same...
• Ecosystem relocation on Snowball Earth: Polar-alpine ancestry of the extant surface biosphere? AI翻译
  作者：Hoffman, Paul F.
  作者单位：University of Victoria; Harvard University
• Abiotic origin of the citric acid cycle intermediates AI翻译
  作者：McAnally, Mason; Bockova, Jana; Turner, Andrew M.; Hara, Nana; Mikhnova, Daria; Meinert, Cornelia; Kaiser, Ralf I.
  作者单位：University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite Cote d'Azur
  摘要：The molecular framework for protometabolism-chemical reactions in a prebiotic environment preceding modern metabolism-has remained unknown in evolutionary biology. Mono-, di-, and tricarboxylic acids that comprise contemporary metabolism, such as the Krebs cycle, are of particular prebiotic relevance and are theorized to predate life on Earth. Researchers have struggled to unravel the molecular origins of respiration, with theories pointing toward abiotic origins later co-opted by the earliest...
• PPARα regulates ER-lipid droplet protein Calsyntenin-3β to promote ketogenesis in hepatocytes AI翻译
  作者：Uchiyama, Lauren F.; Nguyen, Alexander; Qian, Kevin; Cui, Liujuan; Pham, Khoi T.; Xiao, Xu; Gao, Yajing; Shimanaka, Yuta; Tol, Marcus J.; Vergnes, Laurent; Reue, Karen; Tontonoz, Peter
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
  摘要：Ketogenesis requires fatty acid flux from intracellular (lipid droplets) and extrahepatic (adipose tissue) lipid stores to hepatocyte mitochondria. However, whether interorganelle contact sites regulate this process is unknown. Recent studies have revealed a role protein, in the control of lipid utilization in adipose tissue. Here, we show that Clstn3b expression is induced in the liver by the nuclear receptor PPAR alpha in settings of high lipid utilization, including fasting and ketogenic di...
• Cortical scaling of the neonatal brain in typical and altered development AI翻译
  作者：Bonthrone, Alexandra F.; Cromb, Daniel; Chew, Andrew; Gal-Er, Barat; Kelly, Christopher; Falconer, Shona; Arichi, Tomoki; Pushparajah, Kuberan; Simpson, John; Rutherford, Mary A.; Hajnal, Joseph, V; Nosarti, Chiara; Edwards, A. David; O'Muircheartaigh, Jonathan; Counsell, Serena J.
  作者单位：University of London; King's College London; University of London; King's College London; University of London; King's College London; University of London; King's College London; University of London; King's College London
  摘要：Theoretically derived scaling laws capture the nonlinear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been comprehensively assessed in typical or pathological brain development. Here, we assessed the scaling laws governing cortical thickness (CT), surface area (SA), and cortical folding in the neonatal brain. We also assessed multivariate morphological terms that capt...
• Evolutionary divergent kinetoplast genome structure and RNA editing patterns in the trypanosomatid Vickermania AI翻译
  作者：Gerasimov, Evgeny S.; Afonin, Dmitry A.; Skodova-Sverakova, Ingrid; Saura, Andreu; Trusina, Natalia; Gahura, Ondrej; Zakharova, Alexandra; Butenko, Anzhelika; Barath, Peter; Horvath, Anton; Opperdoes, Fred R.; Perez-Morga, David; Zimmer, Sara L.; Lukes, Julius; Yurchenko, Vyacheslav
  作者单位：Lomonosov Moscow State University; University of Ostrava; Comenius University Bratislava; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; University of South Bohemia Ceske Budejovice; Slovak Academy of Sciences; Institute of Chemistry, SAS; Universite Catholique Louvain; Universite Libre de Bruxelles; University of Minnesota System; University of Minnesota Duluth; Fox Chase Cancer Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University
  摘要：The trypanosomatid flagellates possess in their single mitochondrion a highly complex kinetoplast (k)DNA, which is composed of interlocked circular molecules of two types. Dozens of maxicircles represent a classical mitochondrial genome, and thousands of mini-circles encode guide (g)RNAs, which direct the processive and essential uridine insertion/ deletion messenger RNA (mRNA) editing of maxicircle transcripts. While the details of kDNA structure and this type of RNA editing are well establis...
• Quina lithic technology indicates diverse Late Pleistocene human dynamics in East Asia AI翻译
  作者：Ruan, Qi-Jun; Li, Hao; Xiao, Pei-Yuan; Li, Bo; Monod, Helene; Sumner, Alexandra; Zhao, Ke-Liang; Liu, Jian- Hui; Jia, Zhen- Xiu; Wang, Chun- Xin; Fan, An- Chuan; Moncel, Marie- Helene; Marwick, Ben; Peresani, Marco; Wang, You-Ping; Chen, Fa-Hu; Delpiano, Davide
  作者单位：Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Wollongong; University of Wollongong; Universitat Rovira i Virgili; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); DePaul University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Museum National d'Histoire Naturelle (MNHN); University of Washington; University of Washington Seattle; University of Ferrara; Consiglio Nazionale delle Ricerche (CNR); Istituto di Geologia Ambientale e Geoingegneria (IGAG-CNR); Peking University
  摘要：The Late Pleistocene of Eurasia is key for understanding interactions between early modern humans and different types of archaic human groups. During this period, lithic technology shows more diversity and complexity, likely indicating flexible adaptative strategies. However, cultural variability as expressed by technological types remains vague in large parts of eastern Eurasia, like in China. Here, we report a complete Quina technological system identified from the study of the Longtan site ...
• Nuclear Galectin-1 promotes KRAS- dependent activation of pancreatic cancer stellate cells AI翻译
  作者：Vinaixa, Judith; Martinez-Bosch, Neus; Gibert, Joan; Manero-Ruperez, Noemi; Santofimia-Castano, Patricia; Baudou, Federico G.; Vera, Renzo E.; Pease, David R.; Iglesias, Mar; Sen, Sandhya; Wang, Xiyin; Almada, Luciana L.; Marks, David L.; Moreno, Mireia; Iovanna, Juan L.; Rabinovich, Gabriel A.; Fernandez-Zapico, Martin E.; Navarro, Pilar
  作者单位：Hospital del Mar Research Institute; Hospital del Mar; Hospital del Mar Research Institute; Hospital del Mar; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Institute of Biology & Experimental Medicine; Universidad Nacional de Lujan; Mayo Clinic; Hospital del Mar Research Institute; Hospital del Mar; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; University of Buenos Aires; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
  摘要：Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, primarily due to its complex tumor microenvironment (TME), which drives both disease progression and therapy resistance. Understanding the molecular mechanisms governing TME dynamics is essential for developing new treatment strategies for this devastating disease. In this study, we uncover an oncogenic role for Galectin-1 (Gal1), a glycan-binding protein abundantly expressed by activated pancreatic stellate cells (...
• Discovery and functional characterization of a bombesin- type neuropeptide signaling system in an invertebrate AI翻译
  作者：Huang, Weiling; Zhong, Xingxing; Zampronio, Cleidiane G.; Bottrill, Andrew R.; Jones, Kite G. E.; Tinoco, Ana B.; Guo, Lijin; Egertova, Michaela; Mirabeau, Olivier; Elphick, Maurice R.
  作者单位：Universidad de Cadiz; Universidad de Cadiz; University of London; Queen Mary University London; University of Warwick; South China Agricultural University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Neuropeptide signaling systems are key regulators of physiological and behavioral processes in animals. However, the evolutionary history of some neuropeptides originally discovered in vertebrates is unknown. The peptide bombesin (BN) was first isolated from the skin of the toad Bombina bombina and subsequently BN-related neuropeptides have been identified in other chordates, including gastrin-releasing peptide (GRP) and neuromedin B (NMB) in mammals, and a GRP-like peptide in the cephalochord...