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作者：Nielsen, David M.; Chegini, Fatemeh; Serra, Nuno; Kumar, Arjun; Bruggemann, Nils; Hohenegger, Cathy; Ilyina, Tatiana
作者单位：Max Planck Society; University of Hamburg; Helmholtz Association; Helmholtz-Zentrum Hereon
摘要：The ocean carbon cycle is directly impacted by storms in the atmosphere. Tropical cyclones (TCs), particularly, are known to drive intense air-sea CO2 fluxes and to trigger phytoplankton blooms. However, the current generation of Earth system models (ESM) cannot realistically represent TCs due to their coarse spatial resolution (typically 100 to 200 km grid spacing). Here, we present a km-scale coupled, global, storm-and eddy-resolving (5 km ocean, 5 km atmosphere) ESM simulation including oce...
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作者：Zernia, Sarah; Deplazes-Lauber, Joelle; Huber, Jonas; Stigler, Johannes
作者单位：University of Munich; University of Munich
摘要：Bacteriophage T7 RNA polymerase (T7 RNAP) is commonly used for large-scale RNA synthesis in science and industry. Although T7 RNAP exhibits high processivity, its usage faces two major challenges: During initiation, the enzyme frequently aborts transcription, producing potentially immunogenic short RNA by-products; transient pausing during elongation facilitates premature termination, which leads to shorter transcripts and reduces the overall product yield. Here, we present a single-molecule h...
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作者：Baluja, Robert; Guo, Bo; Howden, Wesley; Langer, Ashley; Lemoine, Derek
作者单位：Cornerstone Research; University of Arizona; University of Arizona; National Bureau of Economic Research
摘要：There is evidence of widespread human exposure to per- and polyfluoroalkyl substances that had flowed beneath a PFAS-contaminated site, as opposed to comparable mothers receiving water that had flowed toward a PFAS-contaminated site, had 191% [95% deaths per 100k births); 168% [42-294%] more births before 28 wk of gestational age births with weight below 1,000 g (607 [192-1022] additional such births per 100k births). Extrapolating to the contiguous U.S., PFAS contamination imposes annual soci...
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作者：Fu, Yu-Zhi; Luo, Fang-Fang; Yang, Liu; Zhang, Yu-Xia; Li, Jing-Yang; Wang, Su-Yun; Zhang, Yong; Wang, Yan-Yi
作者单位：Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Changping Laboratory; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Chinese Center for Disease Control & Prevention; World Health Organization
摘要：Human enterovirus A71 (EV-A71) is a major cause of hand, foot and mouth disease. Cellular factors critical for EV-A71 infection remain enigmatic. Here, we performed CRISPR/Cas9 screens and identified sphingolipid transporter 1 (SPNS1) as an essential factor for EV-A71. SPNS1 deficiency inhibits infection of EV-A71 and 9 of 11 examined enteroviruses. Mechanistically, the endo/lysosomal localization of SPNS1 and the acidification of the endo/lysosomes are essential for SPNS1 to support EV-A71 in...
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作者：Nikhil, K. L.; Singhal, Bharat; Granados-Fuentes, Daniel; Li, Jr - Shin; Kiss, Istvan Z.; Herzog, Erik D.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Saint Louis University; Washington University (WUSTL)
摘要：Circadian rhythms in mammals arise from the spatiotemporal synchronization of similar to 20,000 neuronal clocks in the suprachiasmatic nucleus (SCN). Although anatomical, molecular, and genetic approaches have revealed diverse SCN cell types, how network-level wiring enables their synchronization remains unclear. To overcome the challenges of inferring functional connectivity from fixed tissue, we developed Mutual Information & Transfer Entropy (MITE), an information-theoretic framework to inf...
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作者：Wagh, Ajay R.; Glickman, Michael H.
作者单位：Technion Israel Institute of Technology
摘要：UBB+1, a ubiquitin variant protein resulting from a frameshift in the ubiquitin-B gene, is a pathological hallmark of Alzheimer disease (AD). At the cellular level, UBB+1 disrupts the ubiquitin-proteasome system while inducing autophagy. Notably, UBB+1 itself is secreted via autophagosome-like vesicles. Here, we demonstrate that UBB+1 can be removed from the cell by degradative and secretory autophagy. Sequestosome 1 (SQSTM1)/p62 functions as a pivotal ubiquitin receptor for UBB+1, recognizing...
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作者：Wang, Ning; Westermann, Linda M.; Li, Mingyu; Li, Chun - Yang; Murphy, Andrew R. J.; Gu, Zengtian; Silvano, Eleonora; Blindauer, Claudia A.; Lidbury, Ian D. E. A.; Zhang, Yu- Zhong; Scanlan, David J.; Chen, Yin
作者单位：Ocean University of China; Ocean University of China; Shandong University; University of Warwick; University of Birmingham; University of Warwick; University of Sheffield; University of Birmingham
摘要：All cells use lipid membranes to maintain cellular integrity and function, though Archaea utilize lipids composed of glycerol- 1- phosphate (G1P), while Bacteria and Eukaryotes use glycerol- 3- phosphate (G3P). Given that Archaea contribute significantly to global marine biomass, accounting for 0.3 gigatonnes (Gt) of carbon in the oceans, we aimed to uncover how archaeal G1P is recycled by marine microorganisms. Through a multidisciplinary approach combining microbiology, biochemistry, and str...
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作者：Matthews, Kate Layton -; Regan, Charlotte E.; Ballesteros, Manuel; Hodges, Kevin; Descamps, Sebastien; Nilssen, Tycho Anker -; Benjaminsen, Sigurd; Daunt, Francis; Barrett, Robert T.; Buckingham, Lila; Brathen, Vegard Sandoy; Dalsgaard, Signe Christensen -; Dehnhard, Nina; Erikstad, Kjell Einar; Fayet, Annette L.; Helgason, Halfdan H.; Johansen, Malin Kjellstadli; Lorentsenf, Svein-Hakon; Lorentzen, Erlend; Moe, Borge; Systad, Geir Helge; Strom, Hallvard; Searle, Kate R.; Reiertsen, Tone K.
作者单位：Norwegian Institute Nature Research; UK Centre for Ecology & Hydrology (UKCEH); Norwegian Institute Nature Research; University of Reading; Norwegian Polar Institute; Norwegian Institute Nature Research; UiT The Arctic University of Tromso; Norwegian Institute Nature Research
摘要：Climate-driven ocean warming is profoundly reshaping marine ecosystems, with cascading effects on biodiversity and trophic interactions. For migratory marine predators such as seabirds, demographic responses to warming depend on when and where populations are exposed across the annual cycle. Therefore, integrating demographic monitoring and tracking data, across broad geographic and temporal scales, is essential, given the spatial and seasonal variability in ocean warming. Here, we integrated ...
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作者：Postoak, J. Luke; Koch, Alyssa; Shan, Sicong; Ohara, Ray A.; Jo, Suin; Chen, Jing; Desai, Pritesh; Ou, Feiya; Kraft, Magdalena; Diamond, Michael S.; Kim, Sunkyung; Murphy, Theresa L.; Murphy, Kenneth M.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Ajou University
摘要：The intracellular processing route used by type I conventional dendritic cells (cDC1) for cross- presentation of viral- or tumor- associated antigens remains controversial. One model proposes that captured antigens exit from damaged phagolysosomes and enter the cytosol, where they are processed for presentation by MHC class I molecules (MHC- I). This model relies on proteasomal degradation and TAP- dependent peptide transport into the endoplasmic reticulum (ER) for loading by the peptide loadi...
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作者：Power, Megan L.; Ransome, Roger D.; Romaine, Luke; Jones, Gareth; Teeling, Emma C.
作者单位：University College Dublin; University of Bristol
摘要：Life- history trade- offs between reproduction and survival are well documented, yet the biological mechanisms underlying costs remain unclear. Telomere length (TL) is a potential biomarker for such costs, although its association with reproductive efforts is mixed. Bats, particularly the long- lived greater horseshoe bat (Rhinolophus ferrumequinum), provide a rare opportunity to explore these dynamics due to their longevity and low reproductive rates. We examined telomere dynamics in 202 fema...
