50期

最新文章

• Localized nutrient colimitation of phytoplankton growth rates across the subtropical South Pacific Ocean AI翻译
  作者：Yuan, Zhongwei; Liu, Haoran; Gosnell, Kathleen J.; Wen, Zuozhu; Engel, Anja; Dai, Minhan; Achterberg, Eric P.; Browning, Thomas J.
  作者单位：Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; Xiamen University; Xiamen University; Hainan University
  摘要：The simultaneous depletion of multiple nutrients in seawater potentially leads to colimitation of phytoplankton growth across large oceanic extents. Single limitation versus colimitation carries implications for mathematically predicting growth, its response to environmental forcing, and evaluating biogeochemical feedbacks. However, identifying colimited growth has proved challenging due to a lack of appropriate methods. Here, we present the results of 12 experiments conducted across the South...
• Reward- driven adaptation of movements requires strong recurrent basal ganglia-cortical loops AI翻译
  作者：Leblois, Arthur; Boraud, Thomas; Hansel, David
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; CNRS - National Institute for Biology (INSB); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS)
  摘要：The basal ganglia (BG) are a collection of subcortical nuclei involved in motor control, sensorimotor integration, and procedural learning. They play a key role in the acquisition and adaptation of movements, a process driven by dopamine-dependent plasticity at cortico-striatal projections, which serve as BG input. However, BG output is not necessary for executing many well-learned movements. This raises a fundamental question: How can plasticity at BG input contribute to the acquisition and a...
• Pospisil and Pillow, Revisiting the high- dimensional geometry of population responses in the visual cortex (vol 122 , e2506535122 , 2025) AI翻译
  作者：Pospisil, Dean A.; Pillow, Jonathan W.
• Identification of an IRF-ZBP1-caspase-8-NINJ1 axis in driving PANoptosis and pathology during alcohol- associated liver disease AI翻译
  作者：Qin, Qiang; Chen, Wen; King, Clay D.; Kumar, Sivakumar Prasanth; El Farran, Chadi A.; Vogel, Peter; Tweedell, Rebecca E.; Kanneganti, Thirumala - Devi
  作者单位：St Jude Children's Research Hospital; University of Kansas; University of Kansas Medical Center; St Jude Children's Research Hospital
  摘要：Innate immunity provides the critical first line of defense against infection and sterile triggers. Inflammatory cell death is a key component of the innate immune response to clear pathogens, but excessive or aberrant cell death can induce inflammation, cytokine storm, and pathology, making it a central molecular mechanism in inflammatory diseases. Alcohol-associated liver disease (ALD) is one such inflammatory disease, and the specific innate immune mechanisms driving pathology in this conte...
• A balance between glycitein and glyceollins governed by isoflavone 6-hydroxylase confers soybean resistance to Phytophthora sojae AI翻译
  作者：Yang, Qilin; Wang, Yining; Xu, Xindan; Yuan, Jia; Zhang, Fengxia; Qin, Hao; Li, Shihao; Li, Jianxu; Lin, Hao; Li, Lei; Tian, Zhixi; Wang, Guodong
  作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Agricultural Sciences; Biotechnology Research Institute, CAAS; Shanghai Chenshan Botanical Garden; Chinese Academy of Sciences; Yazhouwan National Laboratory
  摘要：Isoflavonoids, predominantly found in legumes, are specialized metabolites with antioxidant properties that benefit both plant resilience and human health. Using metabolic genome-wide association studies (mGWAS), we identified the cytochrome P450 gene (Glyma.11g108300), GmIF6H1, as a key determinant of glycitein biosynthesis in soybean [Glycine max (L.) Merr.]. Biochemical assays together with in planta stable-isotope tracing demonstrated that GmIF6H1 catalyzes the 6-hydroxylation of daidzein,...
• Upper mantle temperatures illuminate the Iceland hotspot track and understanding of ice-Earth interactions in Greenland AI翻译
  作者：Ajourlouio, Parviz; Milne, Glenn A.; Love, Ryan; Afonso, Juan C.; Salajegheh, Farshad; Latychev, Konstantin; Kjeldsen, Kristian K.; Lepipas, Alexis; Martos, Yasmina M.; Woodroffe, Sarah A.
  作者单位：University of Ottawa; University of Twente; Macquarie University; Geological Survey Of Denmark & Greenland; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University System of Maryland; University of Maryland College Park; Durham University
  摘要：The thermal structure of the Earth beneath Greenland reflects the tectonic history of the region and impacts ice sheet evolution due to surface heat flow and the influence of temperature on Earth rheology, and thus glacial isostatic adjustment. We present results from a probabilistic joint inversion of multiple satellite and land-based datasets to determine the thermal structure of the lithosphere and upper mantle beneath Greenland and consider the implications for our understanding of the tec...
• The subcellular architecture of Paratrypanosoma confusum revealed by CryoET: A window into early trypanosome evolution AI翻译
  作者：Alcantara, Carolina de Lima; Poge, Matthias; Baumeister, Wolfgang; Plitzko, Juergen M.; de Souza, Wanderley
  作者单位：Universidade Federal do Rio de Janeiro; Max Planck Society; Max Planck Society; Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de Janeiro; Universidade do Estado do Amazonas
  摘要：The trypanosomatid Paratrypanosoma confusum represents a key evolutionary link between free-living bodonids and parasitic trypanosomes, yet its cellular architecture remains poorly characterized. Here, we used cryofocused ion beam scanning electron microscopy to prepare lamellae for cryoelectron tomography, enabling nanometer-scale imaging of its ultrastructure in near-native conditions. Our analysis revealed structures never before described in trypanosomatids, including an elaborate cytoskel...
• Spiking world model with multicompartment neurons for model-based reinforcement learning AI翻译
  作者：Sun, Yinqian; Zhao, Feifei; Lyu, Mingyang; Zeng, Yi
  作者单位：Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Brain-inspired spiking neural networks (SNNs) have garnered significant research attention in algorithm design and perception applications. However, their potential in the decision-making domain, particularly in model-based reinforcement learning, remains underexplored. In reinforcement learning, a world model refers to a predictive model that learns the environment's dynamics and enables agents to simulate future trajectories in a latent space, thereby improving sample efficiency and long-hor...
• Amazon forest faces severe decline under the dual pressures of anthropogenic climate change and land- use change AI翻译
  作者：Bultan, Selma; Moustakis, Yiannis; Bathiany, Sebastian; Boers, Niklas; Ganzenmuller, Raphael; Gyuleva, Gergana; Pongratz, Julia
  作者单位：University of Munich; Technical University of Munich; Potsdam Institut fur Klimafolgenforschung; University of Exeter; University of Exeter; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society
  摘要：The Amazon is a key climate system component, hotspot of biodiversity and many other ecosystem functions. However, progressive rainforest degradation, driven by anthropogenic climate change and land-use change, is increasing the risk of a large-scale critical ecosystem transition. Previous studies highlight forest vulnerability to isolated or combined climate change and land-use pressures, but have not disentangled individual driver contributions. This crucial knowledge gap needs to be address...
• Building hierarchically nested structure by rapid neural sequences AI翻译
  作者：Lyu, Bingjiang; Qin, Lang; Wang, Xiongfei; Ou, Jianxin; Nour, Matthew M.; Ding, Nai; Gao, Jia- Hong; Liu, Yunzhe
  作者单位：Changping Laboratory; Peking University; Peking University; Capital Medical University; Beijing Normal University; Chinese Institute for Brain Research, Beijing; University of Oxford; Zhejiang University; Zhejiang University; Peking University; Peking University; Peking University
  摘要：Hierarchically nested structures are fundamental to human cognition, enabling complex behaviors across domains including language, planning, and mathematics. However, the neural mechanisms that enable the flexible construction of these hierarchical structures are poorly understood. Here, we designed a task where participants mentally built sequences with nested, multidepth structures by recursively applying a fixed set of rules. Using magnetoencephalography, we find that the brain constructs n...