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作者：Bousdar, Nora; Perez-Ruiz, Elisabeth; Barragan, Isabel; Benitez, Jose Carlos; Rueda-Dominguez, Antonio; Oliver, Javier
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作者：Ekholm, Tobias; Shende, Vivek
作者单位：Uppsala University; Uppsala University; Royal Swedish Academy of Sciences; Mittag-Leffler Institute; University of Southern Denmark; University of California System; University of California Berkeley
摘要：Given a link in the three-sphere, its Lagrangian conormal can be transplanted to the resolved conifold, which is a certain noncompact Calabi-Yau threefold. Here we show that, as predicted by Ooguri and Vafa using string theoretic arguments, the count of all holomorphic curves in the resolved conifold ending on this Lagrangian is, appropriately understood, the collection of the HOMFLYPT invariants of all colorings of the link. This generalizes our previous work, Skeins on branes, arXiv:1901.080...
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作者：Indiveri, Giacomo
作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
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作者：Polisetty, Satya Dev; Dutta, Shuvadip; Vadnala, Rakesh Netha; Notani, Dimple; Padinhateeri, Ranjith; Sanyal, Kaustuv
作者单位：Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Department of Science & Technology (India); Bose Institute
摘要：Fungal centromeres are clustered near microtubule organizing centers to help adopt the Rabl chromosomal organization. The role of centromere clustering in driving large-scale changes in structural and functional chromatin assembly remains unclear. Here, using Hi-C and superresolution microscopy, we show that cell cycle-dependent centromere declustering and clustering states in Cryptococcus neoformans drive global changes in the 3D genome architecture. Centromeres and telomeres are scattered ar...
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作者：Roura -Martinez, David; Popa, Natalia; Jaouen, Florence; Rombaut, Cynthia; Lepolard, Catherine; Bachar, Dipankar; Borges, Ana; Cazorla, Maxime; Villet, Maxime; Moreno, Sebastien; Marie, Helene; Gascon, Eduardo
作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique-Hopitaux de Marseille; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur
摘要：microRNAs (miRNAs) are key regulators of multiple biological functions. Although intensively studied, inactivating miRNAs in vivo is particularly challenging, especially in the brain. Here, we designed cell- specific tools aiming at downregulating defined miRNA species in vivo and investigating their function in discrete neuronal networks. Focusing on miR- 124, a miRNA highly expressed in the mammalian brain and transcribed from three independent chromosomal loci, we designed and validated dif...
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作者：Jia, Li; Liu, Mengdi; Ji, Huiyan; Lei, Jiaxin; Su, Danhua; Li, Lingyi; Liu, Ting; Yuan, Fenghong; Xu, Lin; Cao, Qinghua; Zhang, Huimin; Wen, Zhenke
作者单位：Soochow University - China; Soochow University - China; Nanjing Medical University; Jiangnan University; Zunyi Medical University; University of Sydney; Kolling Institute of Medical Research; Royal North Shore Hospital; University of California System; University of California Riverside
摘要：Lupus nephritis (LN), which is characterized by the accumulation of DNA- containing immune complexes (ICs), is the leading cause of death in patients with systemic lupus erythematosus (SLE). While growing evidence highlights the central role of CD103+ T cells in shaping the immune landscape of regional tissues, mechanisms driving the cell differentiation in LN remain largely unexplored. In this study, we identified an increased frequency of CD4+CD103+ T cells within the kidneys of SLE patients...
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作者：Magzamen, Sheryl
作者单位：Colorado State University System; Colorado State University Fort Collins
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作者：Wang, Pengcheng; Cleveland, Kristan H.; Shahid, Ayaz; Rathnayaka, Chathurika; Amirrad, Farideh; Song, Zhenpeng; Estillore, John Paul; Wang, Ruiwu; Back, Thomas G.; Chen, S. R. Wayne; Huang, Ying
作者单位：Western University of Health Sciences; Capital Medical University; Chapman University System; Chapman University; University of Calgary; Libin Cardiovascular Institute Of Alberta; University of Calgary
摘要：Epidermal growth factor (EGF) induces anchorage-independent growth in promotion-sensitive (P+) mouse epidermal cell model JB6 primarily through activation of the MAPK/ ERK signaling pathway. The beta- blocker carvedilol inhibits EGF-promoted JB6 transformation, but the underlying mechanism is unknown. Since carvedilol suppresses overactivated ryanodine receptors (RyRs) independently of its adrenergic blocking effects, we hypothesized that EGF-promoted transformation requires RyR-mediated calci...
