50期

最新文章

• Mathematical artifacts in slope-intercept correlations invalidate biological inferences in aging research AI翻译
  作者：Moorad, Jacob A.
  作者单位：University of Edinburgh
• Droplet- on- demand mass spectrometry reveals curvature- dependent interfacial reactivity in aqueous microdroplets AI翻译
  作者：Xia, Yu; Gao, Xufeng; Li, Juan; Zare, Richard N.; Chen, Bolei; Zhang, Xinxing
  作者单位：Jianghan University; Stanford University; Nankai University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Research Center for Eco-Environmental Sciences (RCEES), CAS
  摘要：Water microdroplets offer a chemical environment that can dramatically accelerate reaction rates compared to bulk- phase solutions and even drive chemical transformations not found in bulk solutions. While mass spectrometry has proven indispensable for studying microdroplet chemistry, current methods rely on ensemble- averaged data from polydisperse droplet populations, obscuring the molecular details and droplet- size dependencies of reactions in individual droplets. Here, we present a piezoe...
• Fluoride triggers lysis in Streptococcus mutans by inhibition of the Clp protease complex, leading to an unabated competence cascade AI翻译
  作者：Banerjee, Aditya; Pickelner, Sophie; Smith, Faith; Tenuta, Livia M. A.; Stockbridge, Randy B.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Fluoride has long been known to possess antimicrobial properties. For many bacteria, the toxic effects of fluoride are reversible. However, fluoride has also been shown to trigger lysis and cell death in many other diverse bacterial species, including dental pathogens. The underlying molecular mechanisms responsible for fluoride-induced cell lysis have not been established. Using Streptococcus mutans as a model, we show that fluoride elicits an uncontrolled stress response characterized by upr...
• Endogenous forms of ATP-ATP4-and MgATP2--orchestrate distinct pathophysiological signaling via biased activation of P2X3 receptors AI翻译
  作者：Wang, Jin; Guan, Li; Wang, Ting-Ting; Xie, Tang-Xuan; Lin, Yi-Yu; Sun, Meng-Yang; Wang, Dong-Ping; Zhang, Xue; Bian, Yu-Jing; Yue, Chen -Xi; Ding, Bei-Bei; Ma, Xue-Fei; Yu, Ye
  作者单位：China Pharmaceutical University; China Pharmaceutical University
  摘要：P2X receptors, a family of ATP-activated ion channels, encompass subtypes P2X1-7, which are expressed in both homo-and heterotrimeric forms across various tissues. These receptors play crucial roles in pathophysiological processes such as synaptic transmission, nociception, cough, and taste perception. Extracellular ATP exists as both MgATP2-and ATP4-, with P2X3 responding to both. The evolutionary rationale for two nearly identical ligands and their distinct signaling potential remains unclea...
• Functional recovery induced by KCC2-enabled relay pathways in completely injured spinal cords in adult rats AI翻译
  作者：Wang, Yaxian; Liu, Fenglan; Shan, Qi; Wang, Xuzhaoyu; Liu, Wei; Chen, Xinxin; Teng, Cheng; Lv, Yehua; Gu, Xiaosong; Wang, Xuhua; Yu, Bin
  作者单位：Nantong University; Nantong University; Zhejiang University; Zhejiang University
  摘要：Despite tremendous progress in promoting endogenous axon regeneration and engineering relay pathways by cell transplantation, the obtained functional recovery is still limited. We reason that these regenerated connections might not be able to integrate into the functional circuits in injured spinal cord. In this study, we tested whether modulating the neuronal excitability by pharmacological potassium-chloride cotransporter (KCC2) activation could enhance the functional outcomes of these regen...
• Vibrio cholerae biofilm matrix assembly and growth are shaped by a glutamate-specific TAXI/TRAP protein AI翻译
  作者：Potapova, Anna; Oguchi, Rino; Jimmy, Steffi; Evans, Christopher R.; Yarrington, Kaitlin D.; Winans, James B.; Piepoli, Sofia; Older, Ethan A.; Schakel, Olivia F.; Wetherington, Miles T.; Garvey, William; Floyd, Kyle A.; Vinogradov, Evgeny; Yunker, Peter J.; Sanchez, Laura M.; Nadell, Carey D.; Limoli, Dominique H.; Dietrich, Lars E. P.; Sondermann, Holger; Yildiz, Fitnat H.
  作者单位：University of California System; University of California Santa Cruz; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Columbia University; University of Iowa; Dartmouth College; University of California System; University of California Santa Cruz; Indiana University System; Indiana University Bloomington; University System of Georgia; Georgia Institute of Technology; National Research Council Canada; University System of Georgia; Georgia Institute of Technology; University of Kiel
  摘要：Biofilms are critical for the environmental persistence, survival, and infectivity of Vibrio cholerae, the causative agent of cholera. Here, we find that GluP, a glutamate-specific TRAP-TAXI protein, is an uncharacterized matrix component that plays a critical role in biofilm architecture. Loss of GluP reduces biofilm corrugation, expands colony size, and disperses cells from microcolonies, arguing that this factor maintains biofilm structure and organization. While GluP does not affect the ab...
• Convection can enhance the capacitive charging of porous electrodes AI翻译
  作者：Ratschow, Aaron D.; Wagner, Alexander J.; Janssen, Mathijs; Hardt, Steffen
  作者单位：Technical University of Darmstadt; Max Planck Society; Norwegian University of Life Sciences
  摘要：Charge transport in porous electrodes is foundational for modern energy storage technologies like supercapacitors, fuel cells, and batteries. Supercapacitors in particular rely solely on storing energy in charged pores. Here, we simulate the charging of a single electrolyte-filled pore using the modified Poisson-Nernst-Planck and Navier-Stokes equations. We find that electroconvection can substantially speed up the charging dynamics. We uncover the fundamental mechanism of electroconvection du...
• Scaling up actionable climate knowledge AI翻译
  作者：Lemos, Maria Carmen; Maillard, Lisa; Herbert, Natalie; Domingue, Simone J.; Jagannathan, Kripa; Parodi, Gabrielle Wong -; Goto, Erica Akemi; Gill, Devin; Van Berkel, Derek; Kalafatis, Scott; Jorns, Jenna L.; Basaraba, Alex; Harrison, Teal
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Stanford University; Tulane University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Stanford University; University of Arizona; University of Washington; University of Washington Seattle; Stanford University
  摘要：To address climate-driven crises, we need actionable climate knowledge to inform decision-making and support problem solving. Although the science of actionable knowledge is rapidly evolving, less is known about how and why actionable climate knowledge scales up and with what outcomes. We advance three outcome-driven pathways to scale up actionable climate knowledge: 1) broadening participation by increasing the diversity and number of actors involved in actionable climate knowledge coproducti...
• Mapping epileptogenic brain using a unified spatial-temporal-spectral source imaging framework AI翻译
  作者：Jiang, Xiyuan; Cai, Zhengxiang; Gonsisko, Colton; Worrell, Gregory A.; He, Bin
  作者单位：Carnegie Mellon University; Mayo Clinic
  摘要：Noninvasive electrophysiological source imaging (ESI) is a valuable tool for localizing and imaging brain activity, with significant potential to aid presurgical planning in focal drug-resistant epilepsy (fDRE) patients. Scalp electroencephalography (EEG) biomarkers, including interictal spikes, high-frequency oscillations (HFOs), and seizures, each offer unique capabilities in estimating the epileptogenic zone (EZ). However, there is a limited quantitative understanding of how these biomarker...
• Globally aggregated biodiversity data impact predictive and descriptive research AI翻译
  作者：Steinke, Dirk; Gemeinholzer, Birgit; Martinez-Meyer, Enrique; Noesgaard, Daniel; Young, Andrew; Schigel, Dmitry
  作者单位：University of Guelph; Universitat Kassel; Universidad Nacional Autonoma de Mexico; Commonwealth Scientific & Industrial Research Organisation (CSIRO)
  摘要：Here, we present an analysis of the growth and use of the Global Biodiversity Information Facility (GBIF) over the last 5 y. GBIF is the world's largest data integrator for biodiversity information and plays a central role in research across the biodiversity and evolutionary science community. With the help of a comprehensive bibliographic dataset comprising 12,193 studies that used GBIF- mediated data, we demonstrate how the global scientific community utilizes the continuously fast- growing ...