50期

最新文章

• Galectin- related protein, a key contributor, drives diabetes- associated neuropathic pain AI翻译
  作者：Chen, Danyang; Wang, Jing; Song, Xiang - Jie; Ding, Zi - Jiao; Lou, Qianqian; Chen, Yuan - Yuan; Wang, Meng - Yuan; Yang, Xin - Lu; Zhang, Zhi; Li, Juan; Wang, Wei; Wang, Haitao
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University; Anhui Medical University
  摘要：Neuropathic pain associated with central sensitization is common in diabetic patients, but the underlying mechanisms remain unclear. Here, a proteomics screen identified a previously uncharacterized protein, galectin-related protein (LGALSL), which was significantly upregulated in cerebrospinal fluid and extracellular fluid of the anterior cingulate cortex (ACC) in diabetes-related neuropathic pain (DNP) model rats. Exogenous LGALSL administration reduced mechanical nociceptive thresholds by a...
• The olfactory bulb endocast as a proxy for mammalian olfaction AI翻译
  作者：Martinez, Quentin; Molinier, Cecile; Barraza-Soltero, Ilse K.; Berger, Elena; Le Verger, Kevin; Fabre, Anne- Claire; Billet, Guillaume; Fernandez, Vincent; Ferreira, Gabriel S.; van de Kamp, Thomas; Hamann, Elias; Zuber, Marcus; Miguez, Roberto Portela; Hautier, Lionel; Amson, Eli
  作者单位：Max Planck Society; University of Zurich; University of Bern; Natural History Museum London; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; CNRS - Institute of Ecology & Environment (INEE); European Synchrotron Radiation Facility (ESRF); Eberhard Karls University of Tubingen; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Eberhard Karls University of Tubingen; Helmholtz Association; Karlsruhe Institute of Technology; Helmholtz Association; Karlsruhe Institute of Technology; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier
  摘要：Olfaction is a critical sense for tetrapods, playing a key role in survival and reproduction by aiding in food detection, predator avoidance, and social interactions. Olfactory performance has been experimentally tested in only a few taxa, so comparative analyses rely on anatomical and genomic proxies. Among anatomical proxies, the olfactory bulb endocast is widely used, particularly in extinct species, where it is often the only preserved proxy and can be reconstructed even in million-year-ol...
• Actin network heterogeneity tunes activator-inhibitor dynamics at the cell cortex AI翻译
  作者：Maxian, Ondrej; Dinner, Aaron R.; Munro, Edwin
  作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago
  摘要：Biological systems can display diverse patterns of self-organization, even when built on conserved networks of interaction between molecular species. In these cases, reaction-diffusion equations provide a valuable tool to learn how new dynamics could emerge from quantitative tuning of parameters. Bringing these models into quantitative correspondence with biological data remains an outstanding challenge, especially when the data manifest heterogeneities that are difficult to account for mathem...
• Microbial driver of 2006-2023 CH4 growth indicated by trends in atmospheric δD-CH4 and δ13C-CH4 AI翻译
  作者：Riddell, Ben; Michel, Sylvia Englund; Lan, Xin; Tans, Pieter; Rockmann, Thomas; Dasgupta, Bibhasvata; Oh, Youmi; Bruhwiler, Lori M. P.; Fujita, Ryo; Umezawa, Taku; Morimoto, Shinji; Miller, John B.
  作者单位：University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Utrecht University; Japan Meteorological Agency; Meteorological Research Institute - Japan; Tohoku University; National Institute for Environmental Studies - Japan
  摘要：Methane (CH4) is the second most important greenhouse gas and has been rising following a brief period of stabilization from 1999 to 2006. Determining the cause of this rise is critical for reducing emissions and predicting future climate sensitivity. The carbon and hydrogen stable isotopic composition of atmospheric CH4 is controlled by variability in isotopically distinguishable emission categories and fractionating sink processes. While most studies using atmospheric S13C-CH4 data suggest a...
• Reply to Bousdar et al.: Common inherited loss- of- function mutations in the innate sensor NOD2 contribute to exceptional immune response to cancer immunotherapy AI翻译
  作者：Barnet, Megan B.; Jackson, Katherine J. L.; Goodnow, Christopher C.
  作者单位：Garvan Institute of Medical Research; University of New South Wales Sydney; NSW Health; The Kinghorn Cancer Centre; St Vincents Hospital Sydney; University of New South Wales Sydney
• Intracellular Acinetobacter baumannii acts as a transient reservoir in lung infection via a persist and resist strategy AI翻译
  作者：Maitre, Manon Janet -; Di Venanzio, Gisela; Jackson-Litteken, Clay D.; Scott, Nichollas E.; Feldman, Mario F.
  作者单位：Washington University (WUSTL); University of Melbourne; Peter Doherty Institute; University of Arkansas System; University of Arkansas Medical Sciences
  摘要：Although considered primarily extracellular, Acinetobacter baumannii can survive and replicate within macrophages in vitro. Intracellular bacteria are often protected from the host immune system and antibiotic treatment, potentially leading to chronic or recurrent infections. To investigate the role of intracellularA. baumannii during infection, we transferred bronchoalveolar lavage fluid (BALF) from infected mice, containing an intracellular bacterial population, into na & iuml;ve immunocompr...
• Genetics of prelingual isolated deafness and Usher syndrome in the Maghreb and Jordan: Harnessing the potential of homozygosity AI翻译
  作者：Riahi, Zied; Boucher, Sophie; Abdi, Samia; Tai, Fabienne Wongjun; Singh-Estivalet, Amrit; Aghaie, Asadollah; Niasme-Grare, Magali; Hardelin, Jean- Pierre; Behlouli, Asma; Dahmani, Malika; Talbi, Sonia; Bouyacoub, Yosra; Mkaouar, Rahma; Charfeddine, Cherine; Amalou, Ghita; Bakhchane, Amina; Bousfiha, Amale; Salime, Sara; Elrharchi, Soukaina; Salame, Malak; Hadrami, Mouna; Boussaty, Ely; Charoute, Hicham; Detsouli, Mustapha; Snoussi, Khalid; Rouba, Hassan; El Hachmi, Hala; Veten, Fatimetou; Meiloud, Ghlana; Marrakchi, Jihene; Zainine, Rim; Chahed, Houda; Besbes, Ghazi; Trabelsi, Mediha; Mrad, Ridha; Kraoua, Ichraf; Ouhab, Sofiane; Djennaoui, Djamel; Boudjenah, Farid; Chouery, Eliane; Mustapha, Mirna; Houmeida, Ahmed; Barakat, Abdelhamid; Khodja, Fatima Ammar; Makrelouf, Mohamed; Zenati, Akila; Beltaief, Najeh; Abdelhak, Sonia; Peti, Christine; Bonnet, Crystel
  作者单位：Universite Paris Cite; Pasteur Network; Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Hopital Universitaire Saint-Louis - APHP; Institut Pasteur Paris; Universite de Tunis-El-Manar; Pasteur Network; Institut Pasteur Tunis; Universite d'Angers; Centre Hospitalier Universitaire d'Angers; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite d'Angers; CNRS - National Institute for Biology (INSB); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Sorbonne Universite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Armand-Trousseau - APHP; Universite PSL; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); University Science & Technology Houari Boumediene; University Science & Technology Houari Boumediene; Universite de la Manouba; Pasteur Network; Institut Pasteur Du Maroc; Hassan II University of Casablanca; Hassan II University of Casablanca; University of Nouakchott; University of California System; University of California San Diego; Pasteur Network; Institut Pasteur Du Maroc; Pasteur Network; Institut Pasteur Du Maroc; Universite de Tunis-El-Manar; Hopital La Rabta; Universite de Tunis-El-Manar; Hopital Charles Nicolle; Universite de Tunis-El-Manar; Faculte de Medecine de Tunis (FMT); Universite de Tunis-El-Manar; Institut National de Neurologie; Universite de Tunis-El-Manar; Lebanese American University; University of Sheffield; Universite PSL; College de France
  摘要：The molecular genetic diagnosis of prelingual sensorineural hearing impairment (HI) is essential for genetic counseling and patient management. Effective diagnosis requires a knowledge of the genetic architecture of HI, which is often lacking. We established a cohort of 450 unrelated patients with familial (at least two affected relatives) severe-to-profound bilateral prelingual HI in five countries with high consanguinity rates: Tunisia, Jordan, Algeria, Morocco, and Mauritania (the TJAMM coh...
• Computationally efficient whole-genome quantile regression at biobank scale AI翻译
  作者：Wang, Fan; Wang, Chen; Wang, Tianying; Masala, Marco; Fiorillo, Edoardo; Devoto, Marcella; Cucca, Francesco; Ionita-Laza, Iuliana
  作者单位：Columbia University; Colorado State University System; Colorado State University Fort Collins; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); University of Sassari; Lund University
  摘要：Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for continuous phenotypes, is particularly well suited for detecting and characterizing heterogeneous genotype-phenotype associations. Here, we propose a computationally efficient wholegenome quantile regression technique, Regenie.QRS, for biobank-scale genome-wid...
• TAPT1 interacts with SUCO to maintain the homeostasis of newly synthesized proteins and brain development in mice AI翻译
  作者：Gao, Jiawei; Yang, Fuqiang; Jiang, Yisheng; Zheng, Yu; Cai, Lu; Huang, Xiahe; Yuan, Li; Wang, Yingchun; Wang, Yaqing; Xu, Zhiheng
  作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Genetics & Developmental Biology, CAS; Zhejiang University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Genetic mutations in Tapt1 cause complex skeletal dysplasia and structural brain abnormalities. Although the pathogenesis underlying skeletal dysplasia has been explored, the functions and potential mechanisms of transmembrane anterior-posterior transition 1 (TAPT1) during brain development have not been reported. Here, we show that the brains of Tapt1 conditional knockout mice exhibit severe neurodevelopmental defects, including impaired proliferation and differentiation of neural progenitor ...
• The effects of social media criticism against public health institutions on trust, emotions, and social media engagement (vol 122, e2422890122, 2025) AI翻译
  作者：Lee, Jonathan Y.