50期

最新文章

• Multiple weak brakes act in concert to control STIM1 and store- operated calcium entry AI翻译
  作者：Qiu, Ruoyi; Lewis, Richard S.
  作者单位：Stanford Medicine; Stanford University
  摘要：Store- operated Ca2+ entry is a key signaling pathway controlled by the interaction of To avoid generating pathological effects, STIM1 must remain mostly inactive under content. It is not well understood how these conflicting requirements are met. Here we combine single- molecule FRET measurements of full- length dimeric STIM1 in lipid membranes with an AlphaFold2 structural model to describe the structure and regulation of the resting state. We show that STIM1 activity is controlled by the co...
• Coexistence of trapped and flow-transported nuclei enables fast pigeon post communication across multinucleated cell AI翻译
  作者：Tong, Johnny; Wachinger, Kaspar; Henn, Fabian K.; Schramma, Nico; Chen, Siyu; Alim, Karen
  作者单位：Technical University of Munich; University of Amsterdam; Max Planck Society
  摘要：Multi-nucleated cells exist in all domains of life, ranging from animals, plants, and fungi to single-celled organisms such as the slime mold Physarum polycephalum. The large cell size, in the case of Physarum reaching centimeters and more, challenges the coordination of nuclei activity as signals need to cross large distances. In search of a mechanism for fast long-ranged communication among nuclei, we quantify nuclei dynamics and cytoplasmic flows in Physarum's tubular network. We observe nu...
• CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1 AI翻译
  作者：Wang, Shuya; Li, Tong; Naish, Matthew; Chuang, Russell; Lin, Evan K.; Fonkalsrud, Christian; He, Yan; Feng, Suhua; Henderson, Ian R.; Jacobsen, Steven E.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Cambridge; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; Howard Hughes Medical Institute; University of California Los Angeles
  摘要：DNA methylation is a conserved epigenetic modification essential for maintaining genome stability. However, how methyltransferases maintain CG methylation within compact chromatin, including centromeres, remains unclear. In humans, CDCA7 is necessary for the inheritance of DNA methylation at juxta-centromeres. Mutations that impair its ability to bind chromatin result in Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) syndrome, characterized by centromeric instability.To ...
• Distinct neural dynamics in the ventral hippocampus and medial prefrontal cortex during social information processing AI翻译
  作者：Wang, Xinnian; Ma, Zheng; Luo, Yifan; Han, Yechao; Zhan, Chuanzan; Ouyang, Yulin; Zhan, Yang
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of South Africa; Guangzhou University of Chinese Medicine; Shenzhen University of Advanced Technology; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS
  摘要：Social information processing involves coordinated neural activity across distributed brain circuits, with the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) playing pivotal roles. However, whether these regions employ distinct coding strategies for different social stimuli remains unclear. Using in vivo electrophysiological recordings in freely interacting mice, we show that although both regions respond to social cues, they engage divergent neural coding mechanisms. During so...
• A metabolic cell death program downstream of SARM1 couples NAD plus depletion to BAX activation and APAF1 degradation AI翻译
  作者：Pan, Weilong; Guo, Dejia; Liu, Daiyuan; Wang, Xiaodong
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; National Institute of Biological Sciences, Beijing
  摘要：SARM1 is a neuronal Nicotinamide adenine dinucleotide (NAD+) hydrolase that drives axonal degeneration and neuronal death by depleting NAD+, yet how NAD+ loss triggers axon loss and cell death has remained unclear. Here, we define a nonapoptotic death program downstream of endogenous SARM1 activation and NAD+ loss using a genetically tractable nonneuronal eHAP cell model. Upon NAD+ depletion, BAX is activated but caspase activation is suppressed due to APAF1 degradation via the E3 ligase HERC4...
• High-resolution lidar observations of sedimentation-induced size sorting of droplets near a laboratory cloud top AI翻译
  作者：Yang, Fan; Sua, Yong Meng; Zheng, Zipei; Anderson, Jesse; Sadi, Hamed Fahandezh; Yeom, Jae Min; Singh, Suryadev Pratap; Hou, Pei; Cantrell, Will H.; Lewis, Ernie R.; Kostinski, Alex B.; Shaw, Raymond A.
  作者单位：United States Department of Energy (DOE); Brookhaven National Laboratory; Stevens Institute of Technology; Michigan Technological University; Michigan Technological University
  摘要：Cloud optical properties and precipitation, which are crucial to weather and climate, are strongly influenced by cloud microphysical properties that are still poorly understood. Here, we develop a high-resolution time-correlated single-photon-counting lidar and apply it to observe cloud microphysical properties at one-centimeter range resolution in a convection chamber under well-controlled conditions. Together with concurrent in-situ measurements and theoretical analysis, our lidar observatio...
• HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity AI翻译
  作者：Zhang, Lisan; Cai, Shuo; Teng, Ashton; Lin, Ling; Han, Fang; Yan, Han; Hong, Seung - Chul; Pizza, Fabio; Plazzi, Giuseppe; Morandi, Luca; Stefani, Ambra; Hogl, Birgit; Lecendreux, Michel; Bourgin, Patrice; Arnulf, Isabelle; Knudsen -Heier, Stine; Kanbayashi, Takashi; Huang, Yu-Shu; Jennum, Poul; Sonka, Karel; Nevsimalova, Sona; Honda, Makoto; Coelho, Fernando Morgadinho; Pelin, Zerrin; Ferini- Stramb, Luigi; Miyagawa, Taku; Khor, Seik-Soon; Tokunaga, Katsushi; Liu, Wanlu; Mignot, Emmanuel J.
  作者单位：Zhejiang University; Stanford University; Stanford Medicine; Zhejiang University; Peking University; Catholic University of Korea; University of Bologna; IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB); Medical University of Innsbruck; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Robert-Debre - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Robert-Debre - APHP; Universites de Strasbourg Etablissements Associes; CHU Strasbourg; Universite de Strasbourg; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; University of Oslo; University of Oslo; University of Tsukuba; Chang Gung Memorial Hospital; University of Copenhagen; Charles University Prague; Motol University Hospital; Charles University Prague; General University Hospital Prague; Tokyo Metropolitan Institute of Medical Science; Universidade Federal de Sao Paulo (UNIFESP); Hasan Kalyoncu University; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Tokyo
  摘要：Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data from 5,339 cases from China, Europe, Korea, Japan, and the United States to conduct the first transethnic genome-wide association study (GWAS) on age of onset. Only one strong GWAS significant effect was observed across all ethnicities, summarized by the presence of human leukocyte antigen (HLA)-DQB1*03:01,...
• Enhanced dispersion of active microswimmers in confined flows AI翻译
  作者：Lagoin, Marc; Lacherez, Juliette; de Tournemire, Guirec; Badr, Ahmad; Amarouchene, Yacine; Allard, Antoine; Salez, Thomas
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; CNRS - Institute of Physics (INP)
  摘要：In the presence of a laminar shear flow, the diffusion of passive colloidal particles is enhanced in the direction parallel to the flow. This classical phenomenon is known as Taylor-Aris dispersion. Besides, microorganisms, such as active microswimmers, exhibit an effective diffusive behavior at long times. Combining the two ingredients above, a natural question then emerges on how the effective diffusion of active microswimmers is altered in shear flows-a widespread situation in natural envir...
• Neuromodulatory control of energy reserves in dopaminergic neurons AI翻译
  作者：Pulido, Camila; Gentry, Matthew S.; Ryan, Timothy A.
  作者单位：Cornell University; Weill Cornell Medicine; State University System of Florida; University of Florida
  摘要：The brain is a metabolically vulnerable organ as neurons have both high resting metabolic rates and the need for local rapid conversion of carbon sources to ATP during activity. Midbrain dopamine neurons are thought to be particularly vulnerable to metabolic perturbations, as a subset of these are the first to undergo degeneration in Parkinson's disease, a neurodegenerative disorder long suspected to be in part driven by deficits in mid-brain bioenergetics. In skeletal muscle, energy homeostas...
• Electrostatics overcome acoustic collapse to assemble, adapt, and activate levitated matter AI翻译
  作者：Shi, Sue; Hubl, Maximilian C.; Grosjean, Galien; Goodrich, Carl P.; Waitukaitis, Scott
  作者单位：Institute of Science & Technology - Austria; Autonomous University of Barcelona
  摘要：Acoustic levitation provides a unique method for manipulating small particles as it completely evades effects from gravity, container walls, or physical handling. These advantages make it a tantalizing platform for studying complex phenomena in many-particle systems. In most standing-wave traps, however, particles interact via acoustic scattering forces that cause them to merge into a single dense object. Here, we introduce a complementary approach that combines acoustic levitation with electr...