4期

最新文章

• Observation of emergent scaling of spin-charge correlations at the onset of the pseudogap AI翻译
  作者：Chalopin, Thomas; Bojovic, Petar; Wang, Si; Franz, Titus; Sinha, Aritra; Wang, Zhenjiu; Bourgund, Dominik; Obermeyer, Johannes; Grusdt, Fabian; Bohrdt, Annabelle; Pollet, Lode; Wietek, Alexander; Georges, Antoine; Hilker, Timon; Bloch, Immanuel
  作者单位：Max Planck Institute of Quantum Optics; Max Planck Society; Universite Paris Saclay; Institut Polytechnique de Paris; Centre National de la Recherche Scientifique (CNRS); Ecole Polytechnique; Max Planck Society; University of Munich; University of Munich; Lanzhou University; University of Regensburg; Universite PSL; College de France; Simons Foundation; Flatiron Institute; Institut Polytechnique de Paris; Centre National de la Recherche Scientifique (CNRS); Ecole Polytechnique; University of Geneva; University of Strathclyde
  摘要：In strongly correlated materials, interacting electrons are entangled and form collective quantum states, resulting in rich low-temperature phase diagrams. Notable examples include cuprate superconductors, in which superconductivity emerges at low doping out of an unusual pseudogap metallic state above the critical temperature. The Fermi-Hubbard model, describing a wide range of phenomena associated with strong electron correlations, still offers major computational challenges despite its simp...
• Pharmacological chaperones mitigate noise- induced hearing loss by attenuating sustained PERK activation AI翻译
  作者：Hong, Ji Won; Min, Hyehyun; Kim, Soomin; Song, Hyeong Gi; Choi, Yujin; Kim, Chul Hoon; Bok, Jinwoong; Gee, Heon Yung
  作者单位：Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System
  摘要：Noise-induced hearing loss (NIHL) can be either temporary or permanent, depending on the intensity and duration of noise exposure. Excessive noise exposure activates various cellular mechanisms in the cochlea, including oxidative stress, immune responses, and apoptosis. Still, the mechanisms underlying hearing recovery after transient threshold shift (TTS) and lack of recovery after permanent threshold shift (PTS), as well as their therapeutic implications for NIHL, remain unknown. In this stu...
• A quorum- sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen AI翻译
  作者：Lanwermeyer, Stefan Katharios-; Zarrella, Tiffany M.; Godsil, Marshall; Severin, Stefanie; Casiano, Alejandro E.; Tai, Chin- Hsien; Khare, Anupama
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS); Georgetown University
  摘要：Microorganisms commonly exist in polymicrobial communities, where they can respond to interspecies secreted molecules by altering behaviors and physiology; however, the underlying mechanisms remain underexplored. Here, we investigated interactions between Stenotrophomonas maltophilia and Pseudomonas aeruginosa, coinfecting opportunistic pathogens found in pneumonia and chronic lung infections, such as in cystic fibrosis. We found that S. maltophilia forms large protective multicellular aggrega...
• Post-encoding administration of oxytocin selectively enhances memory consolidation of male faces in females AI翻译
  作者：Liu, Wei; Li, Jiashen; Chen, Zhengyue; Zhao, Qingbai; Sun, Xiaojun
  作者单位：Central China Normal University; Central China Normal University
  摘要：Oxytocin plays a critical role in modulating social cognition and enhancing human memory for faces. However, it remains unclear which phase of memory oxytocin affects to enhance face memory. Our study explored oxytocin's potential to selectively enhance the consolidation of social memories, specifically human faces, and whether this effect varies between genders. In three preregistered, randomized, double-blind, placebo-controlled trials with heterosexual participants (total N = 445, comprisin...
• Real-time spatiotemporal tracking of infectious outbreaks in confined environments with a host-pathogen agent-based system AI翻译
  作者：Srinivasan, Suhas; King, Jeffrey; Collins, Jacob M.; Colubri, Andres; Korkin, Dmitry
  作者单位：University of Worcester; Stanford University; Stanford University; Worcester Polytechnic Institute; Worcester Polytechnic Institute
  摘要：Deadly infection outbreaks in confined spaces, whether it is a COVID-19 outbreak on a cruise ship or measles and stomach flu outbreaks in schools, can be characterized by their rapid spread due to the abundance of common spaces, shared airways, and high population density. Preventing future outbreaks and developing efficient mitigation protocols can benefit from advanced computational modeling approaches. Here, we developed an agent-based modeling approach to study the spatiotemporal dynamics ...
• Protein language models trained on biophysical dynamics inform mutation effects AI翻译
  作者：Hou, Chao; Zhao, Haiqing; Shen, Yufeng
  作者单位：Cornell University; Columbia University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Columbia University
  摘要：Structural dynamics are fundamental to protein functions and mutation effects. Current protein deep learning models are predominantly trained on sequence and/or static structure data, which often fail to capture the dynamic nature of proteins. To address this, we introduce SeqDance and ESMDance, two protein language models trained on dynamic biophysical properties derived from molecular dynamics simulations and normal mode analyses of over 64,000 proteins. Both models can be directly applied t...
• Mating regulates growth, metabolism, and digestive efficiency in the female Drosophila midgut AI翻译
  作者：Kandelouei, Tahmineh; Houghton, Madeline E.; Lewis, Mitchell R.; Keller, Caroline C.; Marchetti, Marco; Kang, Xiaoyu; Edgar, Bruce A.
  作者单位：Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
  摘要：Adaptive changes in organ size and function occur in most animals, but how these changes are regulated is not well understood. Previous research found that mating in Drosophila females promotes intestinal stem cell proliferation and increases the overall size of the endodermal portion of the intestine (the midgut). Other studies reported mating-dependent changes in feeding behavior, midgut gene expression, and whole-body lipid storage, suggesting altered metabolism. Here, we show that mating d...
• Noncanonical genetic markers resolve the pre-GOE emergence of aerobic bacteria in Earth's history AI翻译
  作者：Liao, Tianhua; Chen, Shanshan; Wang, Sishuo; Huang, Yongjie; Tsui, Stephen Kwok Wing; Stueken, Eva E.; Cao, Qin; Luo, Haiwei
  作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; University of St Andrews; University of St Andrews; Chinese University of Hong Kong; Chinese University of Hong Kong
  摘要：The transition from anaerobic to aerobic life was a pivotal adaptation in Earth's history, yet the timing and genomic drivers remain poorly resolved. Traditional approaches relying on oxygen-utilizing genes need improvement for obligate anaerobes and fragmentary environmental genomes, where gene absence may reflect poor assembly rather than phenotype. We developed a machine learning model (GBDT40-LR) to predict microbial oxygen requirements using 40 broadly conserved genes, 35 without direct o...
• Symmetry-protected topological polarons AI翻译
  作者：Luo, Kaifa; Lafuente-Bartolome, Jon; Giustino, Feliciano
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Basque Country
  摘要：Emergent quasiparticles in solids often exhibit unique topological properties as a result of the complex interplay between charge, orbital, spin, and lattice degrees of freedom. Among these quasiparticles, the polaron occupies a special place as the first known manifestation of the interaction between a fermion and a boson field. While polarons have been investigated for almost a century, whether these quasiparticles exhibit topological properties and why remain open questions. Here, we establ...
• Manipulating anthracyclines for deeper tissue penetration and implications for glycolytic tissues (vol 122, e2510263122, 2025) AI翻译
  作者：Abels, Erik R.; ter Linden, Esther; Rohling, Jos H. T.; Voortman, Lennard M.; Wander, Dennis P. A.; Janssen, Lennert; Hornsveld, Marten; Overkleeft, Herman S.; van der Zanden, Sabina Y.; Broekman, Marike L. D.; Neefjes, Jacques
  作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Haaglanden Medical Center