4期

最新文章

• Sleep loss induces cholesterol-associated myelin dysfunction AI翻译
  作者：Simayi, Reyila; Ficiara, Eleonora; Faniyan, Oluwatomisin; Cerda, Antonio Cerdan; El Alaoui, Amina Aboufares; Fiorini, Rosamaria; Cutignano, Adele; Piscitelli, Fabiana; Maroto, Aroa S.; Santos, Alexandra; del Gallo, Federico; de Vivo, Luisa; de Santis, Silvia; Bellesi, Michele
  作者单位：University of Camerino; University of Camerino; University of Camerino; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN); Marche Polytechnic University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Chimica Biomolecolare (ICB-CNR); University of Bristol
  摘要：The increasing prevalence of sleep deprivation poses a public health challenge in modern society. Manifestations of reduced alertness, such as slowed reaction times and increased errors, are well-documented behavioral indicators of sleep loss (SL). Yet, the biological consequences of sleep deprivation and their role in behavioral impairment remain elusive. Our study reveals significant effects of sleep deprivation on myelin integrity. As a result, we identify increased conduction delays in ner...
• Nuclear MBL-1 modulates mitochondrial morphology through carnitine palmitoyltransferase in Caenorhabditis elegans with toxic trinucleotide repeats AI翻译
  作者：Teixeira, Joana; Frilander, Mikko J.; Eriksson, Ove; Garcia, Susana M. D. A.
  作者单位：University of Helsinki; University of Helsinki
  摘要：Expansion of nucleotide repeat sequences is linked to a growing number of neuromuscular degenerative disorders. Metabolic changes, including disruptions in mitochondrial function and dynamics, characterize these disorders and are believed to contribute to organismal toxicity. To investigate how toxic RNA repeats affect mitochondria, we used cells and recapitulates muscle dysfunction. We found that the RNA-binding protein Muscleblind-like 1 (MBL-1) is essential for normal mitochondrial function...
• Gpr171 regulates embryonic hematopoietic stem cell emergence via ERK1/2 and Notch signaling AI翻译
  作者：Zhou, Kun; Liu, Hongyan; Zhu, Kai; Yu, Longhai; Xu, Peng -Fei; Li, Yan
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Hematopoietic stem cells (HSCs), which sustain lifelong blood cell production, emerge from hemogenic endothelium during embryonic development through the regulation of multiple signaling pathways. However, generating functional HSCs in vitro remains challenging, underscoring gaps in understanding the underlying mechanisms. Here, we identify GPR171, a P2Y-family G-protein-coupled receptor (GPCR), as a critical regulator of vertebrate embryonic HSC specification. Gpr171 is highly expressed in he...
• Human-induced biospheric carbon sink: Impact from the Taklamakan Afforestation Project AI翻译
  作者：Noor, Salma; Jiang, Xun; Wang, Xinyue; Yang, Jiani; Newman, Sally; Li, King -Fai; Li, Liming; Yu, Le; Li, Xiyu; Yung, Yuk L.
  作者单位：University of Houston System; University of Houston; California Institute of Technology; University of California System; University of California Riverside; University of Houston System; University of Houston; Tsinghua University; Tsinghua University; Tsinghua University
  摘要：The Taklamakan Desert, one of the world's largest and driest deserts, has traditionally been considered a biological void. Here, we demonstrate that large-scale ecological restoration is transforming this hyperarid environment into a carbon sink. By analyzing satellite and ground-based data, we find strong seasonal dynamics: During the wet season (Jul to Sep), precipitation increases to 16.3 mm/mo, enhancing vegetation coverage and photosynthetic activity and drawing down atmospheric CO2 by ap...
• MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis AI翻译
  作者：Shi, Le; Sun, Zehui; Cao, Yingxue; Li, Yuying; Qing, Wenjie; Zhou, Lingli; Xu, Mingming; Mai, Xiaomei; Ou, Lechun; Yang, Xiaoping; Shakiba, Delaram; Ri, Kaoru; Ou, Wangsheng; Chen, Jun; Rosenberg, Avi; Trempe, Jean-Francois; Fon, Edward A.; Liu, Xialin; Cao, Yihai; Duh, Elia J.; Yi, Wei
  作者单位：Sun Yat Sen University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Sun Yat Sen University; McGill University; McGill University; McGill University; Karolinska Institutet
  摘要：Mitochondrial dysfunction is a hallmark of aging and a key contributor to age-related diseases including cardiovascular disease. However, molecular pathways that safeguard mitochondrial homeostasis in the aging heart remain poorly understood. Here, we identify MTFR1L as a regulator of mitophagy that binds p-S65-Ub, a key signal amplifying the PINK1/Parkin axis. We find that MTFR1L is enriched in metabolically active tissues, particularly in the heart, where it regulates Parkin signaling. Genet...
• Bioresponsive immunomodulator nanocomplex for selective immunoengineering in metastatic lymph nodes AI翻译
  作者：Deng, Yueyang; Chen, Mo; Fang, Tianxu; Luo, Tianwen; Cao, Xiaona; Chen, Guojun; Nathan, Carl F.
  作者单位：McGill University; McGill University
  摘要：Lymph node (LN) metastasis (LNM) frequently occurs in various cancer types and is associated with high aggressiveness, poor prognosis, and low survival rates. However, effective clinical interventions remain limited primarily due to the distinctive immunosuppressive microenvironment found in metastatic LNs. Targeted delivery of immunomodulators and selective immunoengineering in metastatic LNs offers a promising avenue for repurposing these LNs as an effective antitumor system while mitigating...
• Metabolic rewiring and biomass redistribution enable optimized mixotrophic growth in Chlamydomonas AI翻译
  作者：Koley, Somnath; Foley, Kevin; Perrine, Zoee; Morley, Stewart A.; Kambhampati, Shrikaar; Gomez, Olivia; Chu, Kevin L.; Chou, Yi -Hsiang; Wei, Michael; Tzeng, Shin -Cheng; Williams, Russell; Umen, James G.; Allen, Doug K.
  作者单位：Donald Danforth Plant Science Center; University of Tennessee System; University of Tennessee Knoxville
  摘要：Aquatic photosynthetic systems account for approximately one-half of all global carbon assimilation and could be a significant source of renewable fuels and feedstocks. However, rapid growth and biomass production in algae have not always translated into high product yields, partly because central metabolism is context specific, with metabolic fluxes being influenced by nutrient conditions and other environmental factors. In the green microalga Chlamydomonas reinhardtii (Chlamydomonas), mixotr...
• Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug AI翻译
  作者：Antonucci, Laura; Watari, Kosuke; Feng, Yechen; Qi, Jingjing; Zhu, Mandy; Wang, Tingya; Ng, Isabella; Vucic, Emily A.; Riahi, Irene; Huang, Li; Hosseini, Mojgan; Mose, Evangeline; French, Randall; Weitz, Jonathan; Bar-Sagi, Dafna; Dawson, David W.; Sun, Beicheng; Tiriac, Herve; Xu, Jinyi; Xu, Shengtao; Lowy, Andrew M.; Karin, Michael
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Southeast University - China; University of California System; University of California San Diego; New York University; University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; UCLA Jonsson Comprehensive Cancer Center; China Pharmaceutical University; China Pharmaceutical University
  摘要：Activation of transcription factor NRF2 in pancreatic ductal adenocarcinoma (PDAC) promotes aggressive tumor phenotype and protection from therapy-induced oxidative stress. We postulated that NRF2high PDAC can be selectively targeted by C29h, a prodrug that is activated by the NRF2-induced enzyme NAD(P)H:quinone oxidoreductase-1 (NQO1), which is elevated in human pancreatic tumors. Initial evaluations of C29h alone or together with the standard-of-care chemotherapeutic drug gemcitabine were co...
• Spatially regulated mRNA translation enables functional membrane protein integration in synthetic cells AI翻译
  作者：Fu, Hang; Ma, Lijuan; Xu, Chunhua; Li, Jinghua; Ouyang, Haochen; Xie, Congbao; Sun, Yunhai; Tao, Yuanxiao; Wang, Hao; Hu, Shuxin; Fu, Meifang; Zheng, Hai; Zhang, Honghong; Liu, Chenli; Ye, Fangfu; Qiao, Yan; Li, Ming; Lu, Ying
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS
  摘要：Synthetic cells aim to emulate living systems by reconstituting essential cellular processes within lipid-bound architectures. However, their functional complexity remains constrained by a key challenge: the synthesis and correct integration of hydrophobic membrane proteins via cell-free approaches. Here, inspired by natural cells, we developed a spatially regulated translation strategy in which membrane-anchored mRNAs recruit ribosomes to drive the cotranslational insertion of membrane protei...
• Polar vortex dynamics on gas giants: Insights from 2D energy cascades AI翻译
  作者：Shi, Jiaru; Kang, Wanying
  作者单位：Massachusetts Institute of Technology (MIT)
  摘要：The distinct polar vortex dynamics observed on Jupiter and Saturn may provide insights into their interiors. In this study, we examine how the number and structure of polar vortices vary with forcing strength, dissipation rate, and interior stratification using a 1.5-layer quasi-geostrophic model. This simplified setup enables a broad exploration of the parameter space, revealing that vortex characteristics are determined by the sequence in which three key length scales-the deformation radius ...