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• David Baltimore: Scientist, leader, and mentor AI翻译
  作者：Andrews, Nancy C.; Daley, George Q.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School
• The contribution of increased global soil salinity to changes in inorganic carbon AI翻译
  作者：Jiang, Xiaofang; Xue, Xian
  作者单位：Chinese Academy of Sciences; Northwest Institute of Eco-Environment & Resources, CAS; Chinese Academy of Sciences; Northwest Institute of Eco-Environment & Resources, CAS; Qinghai Normal University
  摘要：Soil salinization poses a serious environmental challenge, but the impact of global salinity depth, combined with subregional classification (such as soil type, land use, climate, geomorphology, and soil texture) which helps address spatial heterogeneity, we obtain relatively accurate global distribution data for EC (Electrical Conductivity) and SIC. EC of 0 to 40 cm layer positively influences SIC in most taxonomic subregions, which may be due to the inorganic CO2 absorption influenced by pH ...
• A fully synthetic Golden Gate assembly system for engineering a Pseudomonas aeruginosa phiKMV-like phage AI翻译
  作者：Sikkema, Andrew P.; Kortright, Kaitlyn E.; Selvakumar, Hemaa; Antani, Jyot; Chan, Benjamin K.; Davidson, Matthew; Hopkins, Max; Newman, Benjamin; Potapov, Vladimir; Silva-Valenzuela, Cecilia A.; Tabatabaei, S. Kasra; McBride, Robert; Turner, Paul E.; Lohman, Gregory J. S.
  作者单位：Yale University; Yale University; Yale University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：Bacteriophages have applications in biotechnology, including human and veterinary medicine, agriculture, food safety, and biosecurity. One example of resurging importance is phage therapy, the use of phages to treat antibiotic-resistant bacterial infections. Phage therapy currently requires screening of environmental phages against the infecting strains for each individual patient, a laborious process that limits the development of standardized treatments. To overcome limitations of narrow hos...
• Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis AI翻译
  作者：Gervais, Adrian; Bastard, Paul; Zhang, Qian; Jaffar-Bandjee, Marie-Christine; Bizien, Lucy; Dahmane, Lotfi; Moiton, Marie-Pierre; Jabot, Julien; Cally, Radj; Maillard, Alexis; Frumence, Etienne; De Lamballerie, Xavier; Yazdanpanah, Yazdan; Rosain, Jeremie; Cobat, Aurelie; Abel, Laurent; Puel, Anne; Ferdynus, Cyril; Mosnier, Emilie; Gerardin, Patrick; Zhang, Shen-Ying; Casanova, Jean-Laurent
  作者单位：Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Rockefeller University; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; CHU Reunion; CHU Reunion; CHU Reunion; CHU Reunion; CHU Reunion; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bichat-Claude Bernard - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Reunion; CHU Reunion; University of La Reunion; Institut National de la Sante et de la Recherche Medicale (Inserm); Howard Hughes Medical Institute
  摘要：Human autoantibodies neutralizing type I interferons (IFNs) have emerged as strong, common, and global determinants of a growing number of severe viral diseases, including hypoxemic viral pneumonia, arboviral encephalitis, and adverse reaction to the live-attenuated yellow fever virus (YFV) vaccine. Chikungunya virus (CHIKV) is a growing global health concern that the live-attenuated vaccine VLA1553 (IXCHIQ (R)) was developed to address. In 2025, five unrelated adults (aged 82 to 88) on the is...
• mGluR1 signaling is necessary for strengthening winner climbing fiber inputs in the developing mouse cerebellum AI翻译
  作者：Yamasaki, Miwako; Miyazaki, Taisuke; Hashimoto, Kouichi; Takei, Norio; Aiba, Atsu; Kano, Masanobu; Watanabe, Masahiko
  作者单位：Hokkaido University; Hokkaido University; Hiroshima University; Hokkaido University; University of Tokyo; University of Tokyo; University of Tokyo; Teikyo University
  摘要：Functional neural circuits are sculpted by strengthening frequently used synapses and removing unnecessary connections. At birth, cerebellar Purkinje cells receive inputs with similar synaptic strengths from multiple climbing fibers (CFs). During postnatal development, a single winner CF is selectively strengthened and expands its dendritic innervation territory, while somatic loser synapses are eliminated. Here, we report that deleting metabotropic glutamate receptor 1 (mGluR1) or protein kin...
• Broad beta-Coy immunity and transmission blockade by a single-dose live-attenuated vaccine with atypical codon usage AI翻译
  作者：Te, Nigeer; Chin, Alex Wing Hong; Gu, Haogao; Jia, Janice Zhirong; Huang, Yi; Cheng, Samuel Mo Sheung; Tan, Chee Wah; Zhao, Jincun; Hui, Kenrie Pui Yan; Chan, Michael Chi Wai; Feng, Bo; Quadeer, Ahmed Abdul; Mckay, Matthew R.; Wang, Linfa; Valkenburg, Sophie A.; Peiris, Malik; Poon, Leo Lit Man
  作者单位：University of Hong Kong; University of Hong Kong; HKU Pasteur Research Pole; National University of Singapore; National University of Singapore; State Key Laboratory of Respiratory Disease; Guangzhou Medical University; Guangzhou Laboratory; Chinese University of Hong Kong; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; CUHK Shenzhen Research Institute; The Chinese University of Hong Kong, Shenzhen; University of Melbourne; University of Melbourne; Peter Doherty Institute; University of Hong Kong
  摘要：Current COVID-19 vaccines have saved countless lives but primarily aim to induce immunity to the spike or its RBD protein and often fail to confer broad or durable protection against rapidly evolving variants and prevent transmission. Here, we invented a live-attenuated broad-spectrum coronavirus vaccine (cb1) by changing the codon usage bias of SARS-CoV-2 genome, which maintained amino acid conservation but reduced virulence. A single intranasal dose of cb1 vaccine elicits remarkably broad an...
• Mangrove restoration and coastal flood adaptation: A global perspective on the potential for hybrid coastal defenses AI翻译
  作者：Tiggeloven, Timothy; van Zelst, Vincent; Mortensen, Eric; Wesenbeeck, Bregje K. Van; Worthington, Thomas A.; Spalding, Mark; de Moel, Hans; Ward, Philip J.
  作者单位：Vrije Universiteit Amsterdam; Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); Deltares; Delft University of Technology; University of Cambridge
  摘要：To reduce current and future coastal flood risk, it is critical to better understand how adaptation measures, including nature-based solutions, can reduce that risk. Globally, hybrid coastal defenses, including a combination of coastal vegetation, such as salt marshes and mangroves, with a dike or sea wall, have been highlighted as a promising adaptation measure. Here, we present a global-scale assessment of the potential risk reduction from mangrove restoration in combination with foreshore d...
• Cortical O2 supply and metabolism are suppressed in the aged mice AI翻译
  作者：Kang, Hongyi; Zhou, Sitong; Giannetto, Michael; Mcconnell, Evan D.; Kang, Ning; Sun, Qian; Zhao, Hetince; Wei, Helen S.; Kramer, Kevin; Guo, Yaojun; Costa, Juliana S.; Villeda, Saul A.; Nedergaard, Maiken; Wan, Jiandi
  作者单位：University of Rochester; University of California System; University of California Davis; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; University of Kentucky; University of California System; University of California Davis; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Current evidence suggests that the rejuvenating effects of parabiosis on brain function arise from the exchange of blood factors that enhance synaptic plasticity, promote neurogenesis, and reduce neuroinflammation in aged animals. However, aging is also associated with diminished tissue oxygenation. Here, we report that erythrocytes (red blood cells, RBCs) from aged mice exhibit reduced responsiveness to low oxygen tension (PO2) and release O2 slower than those from young mice. In vivo, sensor...
• Functionally heterogeneous intratumoral CD4+CD8+double-positive T cells can give rise to single-positive T cells AI翻译
  作者：Li, Tony; Ilano, Arielle; Arias-Badia, Marcel; Luong, Diamond; Chang, Hewitt; Kwek, Serena S.; Allaire, Kathryn; Chumber, Arun; Sakamoto, Mason; Clark, Matthew; Lea, Averey; Bridge, Mark; Chen, Brandon; Liu, Eric; Porten, Sima; Meng, Maxwell, V; Erlich, Lauren I. R.; Oh, David Y.; Fong, Lawrence
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of Texas System; University of Texas Austin; University of California System; University of California San Francisco; Fred Hutchinson Cancer Center
  摘要：Conventional single-positive (SP) CD4+ and CD8+ T cells recognize tumor antigens and help mediate clinical responses with cancer immunotherapy. Double-positive CD4+CD8+ (DP) T cells have also been described in human cancers, but their role in the tumor microenvironment remains unclear. By generating a multiomic single cell atlas of DP and SP T cells, we find that DP T cells possess phenotypic heterogeneity similar to SP T cells that includes multiple clonally expanded populations of cytotoxic ...
• Droplet growth, Ostwald's rule, and emergence of order in Fused in Sarcoma AI翻译
  作者：Maksudov, Farkhad; Mugnai, Mauro L.; Dominguez, Laura; Makarov, Dmitrii E.; Thirumalai, D.
  作者单位：University of Texas System; University of Texas Austin; Georgetown University; Universidad Nacional Autonoma de Mexico; University of Texas System; University of Texas Austin
  摘要：The low-complexity domain of Fused in Sarcoma (FUS-LC) undergoes phase separation, forming a dense, liquid-like phase that gradually matures into an ordered, gel-like state over long-time scales. During the maturation process, specific regions of the FUS-LC sequence-core-1, core-2, and core-3-become structured, giving rise to non-polymorphic fibrils. Coarse-grained simulations predict that kinetically the least stable fibril-like core-3 forms first while the most stable core-1 appears last, in...