4期

最新文章

• A Period1 inducer specifically advances circadian clock in mice AI翻译
  作者：Takahata, Yoshifumi; Kasashima, Yuki; Yoshioka, Takuya; Yashiki, Shusei; Kulikauskaite, Justina; Matsuura, Tomoaki; Ohba, Yuki; Hasegawa, Hideaki; Yuri, Naoki; Iwai, Nagisa; Otsu, Nanako; Kitakata, Mikiya; Kitaguchi, Yuta; Furune, Haruki; Omori, Chihiro; Mukai, Mutsumi; Komamura-Kohno, Yuki; Huang, Yi-Ying; Hirose, Matsumi; Koike, Nobuya; Yamada, Yoichi; Nakazawa, Kazuo; Ui-Tei, Kumiko; Sakaki, Yoshiyuki; Numano, Rika; Uriu, Koichiro; Tei, Hajime
  作者单位：University of Osaka; University of Osaka; Kanazawa University; Kanazawa University; Mitsubishi International Corporation (MIC); Mitsubishi Kagaku Institute of Life Sciences (MITILS); Kyoto Prefectural University of Medicine; Toyohashi University of Technology; University of Tokyo; Institute of Science Tokyo; University of Tokyo; Toyohashi University of Technology; Institute of Science Tokyo
  摘要：West-to-east transmeridian flights are more disruptive than east-to-west ones due to challenges in advancing the human circadian clock. Transient mammalian Period1 (Per1) induction was predicted to predominantly advance the clock phase in our previous work. Here, we unravel a specific Per1 inducer, Mic-628, enabling abrupt phase advance in mouse behavioral rhythms, regardless of the timing of oral administration. Mic-628-treated mice re-entrain to phase-advanced light-dark cycles significantly...
• Direct observation of liquid-liquid phase coexistence in deeply supercooled water using an accurate polarizable multipole model AI翻译
  作者：Wang, Lee-Ping; Berrens, Margaret L.; Donadio, Davide
  作者单位：University of California System; University of California Davis; United States Department of Energy (DOE); Lawrence Livermore National Laboratory
  摘要：Liquid water can be supercooled up to about 50 K below the melting point before undergoing homogeneous ice nucleation. Based on experimental thermodynamic observations and computer simulations, it was hypothesized that below this temperature and at pressures of several kbar, water undergoes a liquid-liquid phase transition (LLPT) and the transition line ends at a second critical point. However, challenges in experiments and simulations at such deep cooling leave doubts about the nature of the ...
• Combinatorial asymmetric acoustic metamaterials with real-time programmability (vol. 122, e2502036122, 2025) AI翻译
  作者：Keogh, Melanie R.; Bilal, Osama R.
• Dynamics of working memory drift and information flow across the cortical hierarchy AI翻译
  作者：Li, Hsin -Hung; Ma, Wei Ji; Curtis, Clayton E.
  作者单位：New York University; University System of Ohio; Ohio State University; New York University
  摘要：Working memory is supported by widespread and distributed brain regions spanning across the cortical hierarchy. However, how working memory content evolves and is transmitted across cortical regions remains largely unknown. Here, we investigated the flow of working memory information across the cortex using time-resolved fMRI decoding. Across multiple regions in visual and parietal cortex, we found that decoded working memory content drifted over time from the memoranda toward the later errors...
• A data-driven chromatin model reveals spatial and dynamic features of genome organization AI翻译
  作者：Oliveira Junior, Antonio B.; Mello, Matheus F.; Oliveira, Ronaldo J.; Dodero-Rojas, Esteban; Brahmachari, Sumitabha; Contessoto, Vinicius G.; Onuchic, Jose N.
  作者单位：Rice University; Universidade Federal do Triangulo Mineiro; Rice University; Rice University; Rice University
  摘要：Compacting chromatin within the cellular nucleus presents a significant challenge for biology. Chromosomes must be both condensed and spatially organized to enable essential processes such as transcription and replication. Chromosome conformation capture experiments (e.g., Hi-C) provide valuable information about the spatial organization and, therefore, the connectivity between different genomic regions. These experiments inspired polymer models that describe the physical mechanism of the chro...
• In situ observations of gold deposition in a dense liquid layer at the pyrite-water interface AI翻译
  作者：Tang, Hongmei; Xian, Haiyang; Deng, Teng; He, Zhaolu; Li, Shan; Yang, Yiping; Liao, Honggang; Jiang, Youhong; Xi, Jiaxin; Zhu, Jianxi; He, Hongping
  作者单位：Jiangxi Academy of Sciences; Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; East China University of Technology; Xiamen University
  摘要：Pyrite-triggered precipitation of gold nanoparticles (AuNPs) is crucial for generating high-grade gold deposits, yet its dynamic process and mechanism at the pyrite-water interface remain unclear due to the lack of in situ observation. Here, utilizing in situ liquid cell transmission electron microscopy, we find a dense liquid layer mediated deposition of AuNPs at the pyrite-water interface in parts per billion-level gold-bearing solutions, a concentration that resembles crustal abundances. Re...
• Quantifying the compressibility of the human brain AI翻译
  作者：Weaver, Nicholas J.; Faskowitz, Joshua; Betzel, Richard F.; Lynn, Christopher W.
  作者单位：Yale University; Yale University; Yale University; Indiana University System; Indiana University Bloomington; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Yale University
  摘要：In the human brain, the allowed patterns of activity are constrained by the correlations between brain regions. Yet it remains unclear which correlations-and how many- are needed to predict large-scale neural activity. Here, we present an information-theoretic framework to identify the most important correlations, which provide the most accurate predictions of neural states. Applying our framework to cortical activity in humans, we find that the vast majority of variance in activity is explain...
• Mechanistic basis for relaxation of DNA supercoils by human topoisomerase IIIα-RMI1-RMI2 AI翻译
  作者：Spakman, Dian; Biebricher, Andreas S.; Bizard, Anna H.; Hickson, Ian D.; Peterman, Erwin J. G.; Wuite, Gijs J. L.; King, Graeme A.
  作者单位：Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of Copenhagen; University of London; University College London; Birkbeck University London
  摘要：Topoisomerase enzymes are essential for the regulation of DNA topology. Human topoisomerase III alpha is a Type 1A topoisomerase that exists as a complex with RMI1 and RMI2, known as TRR. The TRR complex can unlink entwined DNA strands and is known to be important for resolving DNA replication and recombination intermediates. It has recently been proposed that TRR can also relax transient negatively supercoiled loops of DNA generated by the translocase PICH and that this activity may help to f...
• Molecular architecture and diversity of StopGo/2A translational recoding AI翻译
  作者：Li, Xueyan; Zuber, Philipp K.; Loughran, Gary; Bhatt, Pramod R.; Alquraish, Fatema; Ramakrishnan, V.; Firth, Andrew E.; Atkins, John F.
  作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University College Cork; University of Cambridge; Boehringer Ingelheim; King Abdullah University of Science & Technology
  摘要：Viral 2A sequences trigger a cotranslational peptide bond formation skipping event, termed StopGo, to generate two separate proteins from a single open reading frame without classical termination. To investigate the mechanism of StopGo, we determined the cryo-EM structure of a mammalian ribosome positioned at the foot-and-mouth disease virus 2A (F2A) site. Te structure shows how interactions between the F2A nascent chain (NC) and the ribosomal exit tunnel induce a conformational change in the ...
• Differential Hes1 activation defines neural stem cell lineage commitment and niche maintenance in embryonic and adult mouse cortex AI翻译
  作者：Riya, Paul Ann; Jose, Rahul; Meera, Vadakkath; Basu, Budhaditya; Surya, Suresh; Aryasree, Ramankunju; Jyothi, Nair Pradeep; Parvathy, Surendran; Dhanesh, Sivadasan Bindu; Sanalkumar, Rajendran; Praz, Viviane; Riggi, Nicolo; James, Jackson
  作者单位：Department of Biotechnology (DBT) India; Rajiv Gandhi Centre for Biotechnology (RGCB); University of Kerala; Department of Biotechnology (DBT) India; Regional Centre for Biotechnology; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Johns Hopkins University; University of Iowa; Stanford Medicine; Stanford University; Children's Mercy Hospital; Roche Holding; Roche Holding USA; Genentech
  摘要：Mode of Hes1 activation and its differential expression are crucial for the maintenance of neural stem cells/progenitor cells (NSCs/NPCs) in the embryonic cortex. This differential mode of Hes1 activation has been translated into a heterogeneous population of NSCs comprising Notch-independent Hes1-expressing (NIHes1) NSCs and Notch-dependent Hes1-expressing (NDHes1) radial glial cells (RGCs). Using single-cell transcriptomics and a Nestin-CreERT2;NIHes1fl/fl conditional knock-out mouse model, ...