4期

最新文章

• DNA polymerase delta governs parental histone transfer to DNA replication lagging strand (vol 121, e2400610121, 2024) AI翻译
  作者：Tian, Congcong; Zhang, Qin; Jia, Jing; Zhou, Jiaqi; Zhang, Ziwei; Karri, Srinivasu; Jiang, Jiuhang; Dickinson, Quinn; Yao, Yuan; Tang, Xiaorong; Huang, Yuxin; Guo, Ting; He, Ziwei; Liu, Zheng; Gao, Yuan; Yang, Xinran; Wu, Yuchun; Chan, Kui Ming; Zhang, Daoqin; Han, Junhong; Yu, Chuanhe; Gan, Haiyun
• Pore size dynamics control complex volume swelling in pyroptosis AI翻译
  作者：Bastien, Estelle; Duprez, Guillaume; Delanoe-Ayari, Helene; Leloup, Hubert; Riviere, Charlotte; Petrilli, Virginie; Recho, Pierre; Monnier, Sylvain
  作者单位：Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; CNRS - Institute of Physics (INP); Universite Grenoble Alpes (UGA); Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); UNICANCER; Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); Centre Leon Berard
  摘要：Pyroptosis, an inflammatory form of cell death, is characterized by massive cell swelling and plasma membrane rupture. Although swelling was recently shown to occur in two steps, the molecular and biophysical mechanisms driving this process remained unclear. Using fast quantitative microscopy, we reveal that between the two swelling phases, cell volume transiently stabilizes despite sustained plasma membrane permeability to ions and small molecules. From a biophysical perspective, the existenc...
• Probing the dark energy in the functional protein universe AI翻译
  作者：Galpern, Ezequiel A.; Bueno, Carlos; Sanchez, Ignacio E.; Wolynes, Peter G.; Ferreiro, Diego U.
  作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; Rice University; Rice University; Rice University; Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG)
  摘要：We show how to localize and quantify the functional evolutionary constraints on natural proteins. Protein folding has been one of the strongest constraints in sequence evolution. The method we propose compares the perturbations caused by local sequence variants to the energetics of the protein folding process and to the corresponding change to the apparent selection landscape of sequences over the evolutionary time scale. The difference between the physical folding free energies and the evolut...
• A surface-exposed cardiolipin synthase provides an unexpected paradigm for maintaining the Gram-negative outer membrane AI翻译
  作者：Herrera, Carmen M.; Demey, Lucas M.; Ellison, Courtney K.; Trent, M. Stephen
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
  摘要：Gram-negative bacteria have long been thought to confine primary glycerophospholipid synthesis to the inner membrane (IM). Here, we challenge this paradigm by identifying ClsO, an outer membrane (OM) lipoprotein from Acinetobacter baumannii that functions as a cardiolipin synthase. In contrast to canonical cardiolipin synthases, which are restricted to the IM, ClsO is surface-exposed and deposits cardiolipin into the outer leaflet of the OM, colocalizing with Acinetobacter lipooligosaccharide....
• A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction AI翻译
  作者：Jo, Yong Sang; Kong, Mi -Seon; Sethi, Ekayana; Pyeon, Gyeong Hee; Zweifel, Larry S.
  作者单位：Korea University; University of Washington; University of Washington Seattle; Salk Institute; University of Washington; University of Washington Seattle
  摘要：How positive and negative affective stimuli interact in the brain to influence behavioral outcomes remains poorly understood. Here, we show that recall of a positively valenced reward-associated cue (reward-conditioned stimulus, CSRew+) can prevent or reverse fear generalization in mice. Modification of generalized fear by recall of a CSRew+ is dependent on the midbrain dopamine system and the regulation of discriminatory fear encoding by the central amygdala (CeA). Precisely timed, transient ...
• Anharmonicity driven unusual particle-to-wave-like phonon crossover leads to ultralow thermal conductivity in Tl2AgI3 AI翻译
  作者：Pathak, Riddhimoy; Paul, Sayan; Biswas, Shuva; Pati, Swapan K.; Biswas, Kanishka
  作者单位：Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR); Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR)
  摘要：Realization of unusual particle-to-wave-like crossover in phonon transport and understanding its fundamental structural origin can guide the design of materials with ultra-low thermal conductivity. Here, we report such a crossover from particle-like phonon propagation to wave-like coherence with increasing temperature in the zero-dimensional (0D) metal halide, Tl2AgI3. Composed of discrete (Tl6I)(5+)and (Ag3I8)(5-) subunits, the structure exhibits intrinsic lattice instability governed by Paul...
• Caspase-3 cleaves and activates the NADase SARM1 to promote apoptosis, linking two cell death mechanisms AI翻译
  作者：Shi, Jianjin; Kim, Ye Eun; Deruiter, Nicolas Jose; Kadav, Priyanka; Tessier -Lavigne, Marc
  作者单位：Stanford University; Rockefeller University; Rockefeller University
  摘要：Two major mechanisms of axon degeneration have been identified. The first, a caspase-dependent apoptotic pathway, is a major mediator of developmental axon degeneration triggered by loss of trophic support. The second, a caspase-independent pathway mediated by the sterile alpha and HEAT/Armadillo motif containing 1 (SARM1) NADase, was found in studies of injury-induced Wallerian degeneration; it is also implicated in degeneration associated with traumatic brain injury, as well as some neurodeg...
• Ubiquitination of BAM1 attenuates CLE peptide-mediated signaling in the root apical meristem AI翻译
  作者：Zhou, Yuanyuan; Liu, Fei; Han, Yongfeng; Bai, Jiaojiao; Zhang, Baowen; Tang, Wenqiang; Gou, Xiaoping; Zhang, Yan; Lu, Dongping
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; Center for Agricultural Resources Research, Institute of Genetic & Developmental Biology, CAS; Institute of Genetics & Developmental Biology, CAS; Nankai University; Hebei Normal University; Lanzhou University
  摘要：The plasma membrane-resident receptor-like kinases (RLKs) and their cognate peptide ligands play crucial roles in plant growth and development. The RLK BARELY ANY MERISTEM1 (BAM1) promotes phloem formation and regulates other aspects of root development. However, the mechanisms governing BAM1 protein degradation remain unclear. In this study, we demonstrate that two closely related ubiquitin ligases, RING DOMAIN LIGASE 1 (RGLG1) and RGLG2, specifically interact with BAM1 and its closest homolo...
• Nitrate-induced NLP1 SUMOylation regulates nitrate signaling and root nodulation AI翻译
  作者：Liu, Jing; Luo, Zhenpeng; Wang, Jiang; Lin, Jieshun; Xie, Fang
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National University of Singapore
  摘要：Nitrate serves both as an essential nutrient and a key signaling molecule that shapes plant growth. In legumes, high nitrate concentrations suppress symbiotic nitrogen fixation, a process mediated by MtNLP1 (NIN-like protein1). Although nitrate minimally affects NLP transcript levels, it strongly controls their nuclear localization. How posttranslational modifications regulate MtNLP1 function, however, has remained unclear. Here, we show that nitrate induces SUMOylation of MtNLP1 at lysine 589...
• Genetic associations with education have increased and are patterned by socioeconomic context: Evidence from 3 studies born 1946-1970 AI翻译
  作者：Morris, Tim T.; Wright, Liam; Shireby, Gemma; Bann, David
  作者单位：University of London; University College London; UCL Institute of Education
  摘要：Social scientists have long sought to investigate whether the predictors of educational attainment (EA) have changed across time. Here, we provide insights by incorporating genetic predictors of education in three nationally representative British birth cohorts born in 1946, 1958, and 1970. We investigated whether individual characteristics as proxied by polygenic indexes (PGIs) for EA and cognition have become more relevant to educational success over time and whether returns to genetic predi...