4期

最新文章

• GFP-free live neuron quantitative imaging reveals compartmentalization and growth dynamics of polyQ aggregates AI翻译
  作者：Bi, Xiaotian; Suen, Berea; Lin, Li -En; Miao, Kun; Wei, Lu
  作者单位：California Institute of Technology; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of California System; University of California San Francisco
  摘要：Huntington's Disease (HD), the most prevalent polyglutamine (polyQ) neurodegenerative disorder, features brain aggregates induced by mutant huntingtin (mHtt) proteins harboring expanded polyQ tracts. Despite extensive efforts, molecular mechanisms of polyQ aggregates remain elusive. Here, we establish quantitative stimulated Raman scattering imaging of polyQ aggregates (q-aggSRS) for noninvasive investigations in live neuronal cocultures using deuterated glutamine labeling. Q-aggSRS allows for...
• Paleoclimate pattern effects help constrain climate sensitivity and 21st-century warming AI翻译
  作者：Cooper, Vincent T.; Armour, Kyle C.; Hakim, Gregory J.; Tierney, Jessica E.; Burls, Natalie J.; Proistosescu, Cristian; Andrews, Timothy; Dong, Wenhao; Dvorak, Michelle T.; Feng, Ran; Osman, Matthew B.; Dong, Yue
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Arizona; George Mason University; University of Illinois System; University of Illinois Urbana-Champaign; Met Office - UK; Hadley Centre; University of Leeds; National Center Atmospheric Research (NCAR) - USA; National Oceanic Atmospheric Admin (NOAA) - USA; University of Connecticut; University of Cambridge; University of California System; University of California Los Angeles; Massachusetts Institute of Technology (MIT); Tsinghua University
  摘要：Paleoclimates provide examples of past climate change that inform estimates of modern warming from greenhouse-gas emissions, known as Earth's climate sensitivity. However, differences between past and present climate change must be accounted for when inferring climate sensitivity from paleoclimate evidence. The closest paleoclimate analog to near-term warming from greenhouse-gas emissions is the Pliocene (5.3 to 2.6 Ma), a warm epoch with atmospheric CO2 concentrations similar to today. Recent...
• 撤稿声明: Nanospherical arabinogalactan proteins are a key component of the high-strength adhesive secreted by English ivy AI翻译
  作者：Huang, Yujian; Wang, Yongzhong; Tan, Li; Sun, Leming; Petrosino, Jennifer; Cui, Mei-Zhen; Hao, Feng; Zhang, Mingjun
• Slippage reconfiguration of trinucleotide repeat hairpins impedes resolution by human replication protein A AI翻译
  作者：Kuang, Yu-Chi; Chen, Szu-Yu; Chang, Hao-Yen; Ni, Cheng-Wei; Chi, Peter; Lee, I-Ren
  作者单位：National Taiwan Normal University; Academia Sinica - Taiwan; National Taiwan University; Academia Sinica - Taiwan; National Taiwan University; National Taiwan University; Academia Sinica - Taiwan
  摘要：Abnormal expansions of trinucleotide repeats (TNRs) are a major cause of neurodegenerative diseases, often driven by the formation of stable hairpin structures that interfere with protein machineries in DNA cellular processes. On the other hand, human replication protein A (hRPA) plays a central role in stabilizing single-stranded DNA and resolution of secondary structures. Understanding how hRPA interacts with TNR hairpins has become crucial to uncovering the mechanisms that regulate TNR stab...
• Platelet-derived growth factor receptor alpha regulates fetal testis differentiation via an ERK-CREB axis AI翻译
  作者：Li, Shu -Yun; Matsuyama, Satoko; Whiteside, Sarah; Gu, Xiaowei; Cool, Jonah; Capel, Blanche; Defalco, Tony
  作者单位：Cincinnati Children's Hospital Medical Center; Duke University; University System of Ohio; University of Cincinnati
  摘要：Platelet-derived growth factor receptor alpha (Pdgfra) plays a crucial role in mesenchymal cell differentiation, but the molecular signaling involved in this process remains unclear, particularly within the fetal testis. Here, we use XY Pdgfra-null gonads to investigate the molecular mechanisms underlying testicular organogenesis, focusing on the formation of testicular architecture and the differentiation of fetal Leydig cells (FLCs), the steroidogenic lineage arising from mesenchymal precurs...
• Widespread terrestrial ecosystem disruption at the onset of the Paleocene-Eocene Thermal Maximum AI翻译
  作者：Nelissen, Mei; Willard, Debra A.; Cittert, Han van Konijnenburg-van; Bowen, Gabriel J.; Hollaar, Teuntje; Sluijs, Appy; Frieling, Joost; Brinkhuis, Henk
  作者单位：Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Utrecht University; United States Department of the Interior; United States Geological Survey; Utah System of Higher Education; University of Utah; University of Oxford; Ghent University
  摘要：The Paleocene-Eocene Thermal Maximum (PETM, similar to 56 Mya) interval was marked by massive C-13-depleted carbon emissions into the ocean/atmosphere system, manifested as a negative carbon isotope excursion (CIE) in sedimentary components, and similar to 5 degrees C global average warming. Episodes of hydrological perturbations and soil-erosion have been widely documented for the PETM but their link with vegetation-and carbon cycle changes remain poorly constrained. Here, we present organic ...
• α2-macroglobulin function of thioester-containing proteins guards Drosophila from a bacterial protease via two immune-induced peptides AI翻译
  作者：Cai, Chuping; Acker, Adrian; Huang, Jianqiong; Liu, Yingying; Molino, Maria Victoria; Mariscotti, Javier F.; Garcia-Vescovi, Eleonora; Bulet, Philippe; Hammann, Philippe; Chicher, Johana; Liegeois, Samuel; Li, Zi; Hoffmann, Jules A.; Matt, Nicolas; Ferrandon, Dominique
  作者单位：Guangzhou Medical University; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; National University of Rosario; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; CNRS - National Institute for Biology (INSB); Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA); CNRS - National Institute for Biology (INSB)
  摘要：RNAseq analysis of the Drosophila genome has revealed further immune-induced genes. Two genes initially annotated as lncRNAs, CG44404(yul & uuml;) and CG45045(shenshu), are strongly induced. We report here that these two genes actually encode highly related secreted peptides found in the Sophophora subgenus of Drosophila species. We have generated single and double null mutants of these loci and found that the double mutant line did not display any enhanced susceptibility to an immune challeng...
• Calumenin prevents fibroblast senescence and lung aging by promoting vimentin proteostasis AI翻译
  作者：Dong, Ting; Jiao, Xue; Wang, Huirui; Gao, Yinghui; Xu, Yuliang; Li, Hui; Fang, Senbiao; Chen, Xinyi; Wang, Mengmeng; Zhu, Hanbing; Li, Nianyu; Han, Bo; Qi, Mei; Lyu, Kaige; Ma, Kaicheng; Li, Ke; Fu, Haigen; Gu, Bowen; Li, Wenfei; Qin, Yingying; Chen, Zi-Jiang; Liu, Xiaohui; Lou, Hongxiang
  作者单位：Shandong University; Shandong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Shandong University; Shandong University; Ocean University of China; University of London; King's College London; Shandong University; Shandong University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Materia Medica - CAMS; Harvard University; Shandong University; Shandong University
  摘要：Progressive lung fibrosis is linked to aging-related dysfunction in fibroblasts, which remains poorly understood. To investigate the alterations in fibroblasts, particularly the molecular programs driving this profibrotic evolution in the aging lung, we isolated senescent lung fibroblasts from aged mice. We observed aberrant vimentin aggregates, which correlate with accelerated fibroblast senescence. CRISPR-based screening identified calumenin as a chaperone protein essential for vimentin prot...
• A class of COPI cargo receptors regulates processing of transmembrane proteins by reinforcing their Golgi retention AI翻译
  作者：Gao, Jinghu; Cong, Chengge; Wu, Yanfang; Xiang, Yun; Yan, Bing; Jia, Qinyu; Yao, Zhong-ping; Guo, Yusong; Hu, Junjie
  作者单位：Nankai University; Chinese Academy of Sciences; Institute of Biophysics, CAS; Hong Kong University of Science & Technology; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Shaoxing University
  摘要：Many transmembrane (TM) signaling receptors undergo essential posttranslational modification in the Golgi prior to their delivery to the plasma membrane (PM). Whether and how the passage and accompanied modification of these proteins across the Golgi is controlled remains unclear. Here, we show that leptin receptor overlapping transcript (LEPROT) and LEPROT-like 1 (LEPROTL1) regulate TM receptor activation by securing their sufficient Golgi retention. LEPROTs localize to cis and medial Golgi i...
• Earliest perissodactyls reveal large-scale dispersals during the PETM AI翻译
  作者：Tissier, Jeremy; Smith, Thierry
  作者单位：Royal Belgian Institute of Natural Sciences; University of Fribourg; University of Namur
  摘要：Perissodactyls were a diverse order of mammals in the Northern Hemisphere during the Paleogene, but very few species remain today. They first appear during the Paleocene-Eocene Thermal Maximum (PETM; 56 Ma) on the three continents of the Northern Hemisphere. Because they lack modern diversity, the study of their evolutionary history remains difficult, relying almost exclusively on fossils. In addition, their origin and early diversification remain elusive since all main groups appear at the sa...