17期

最新文章

• Targeting the polyene chain represents an adjuvant strategy for optimizing polyene antifungals AI翻译
  作者：Zhang, Yishan; Liu, Xiaocong; Weng, Luobei; Li, Shuixiu; Chen, Peiran; Zhang, Gehua; Wang, Jianqi; Zhang, Dongmei; Tang, Chuanyan; Hu, Yunfeng; Ye, Wencai; Zhang, Hong
  作者单位：Jinan University; Jinan University; Jinan University; Sun Yat Sen University; Jinan University
  摘要：Polyene antifungals (PAs) have long constituted an irreplaceable lifesaving treatment for lethal fungal infections. However, PAs induce significant dose- dependent nephrotoxicity, primarily because of their binding to cholesterol in the renal cell membrane, which is structurally similar to their fungicidal target ergosterol in the fungal membrane. Efforts to optimize PAs have focused mainly on their mycosamine group and polyol chain, while the potential of the polyene chain remains underexplor...
• Rotational 3D printing of active-passive filaments and lattices with programmable shape morphing AI翻译
  作者：Abdelrahman, Mustafa K.; Wilt, Jackson K.; Jung, Yeonsu; Telles, Rodrigo; Paink, Gurminder K.; Larson, Natalie M.; Aizenberg, Joanna; Mahadevan, L.; Lewis, Jennifer A.
  作者单位：Harvard University; Stanford University; Harvard University; Harvard University; Harvard University; Harvard University
  摘要：Natural filaments, such as proteins, plant tendrils, octopus tentacles, and elephant trunks, can transform into arbitrary three-dimensional shapes that carry out vital functions. Their shape-morphing behavior arises from intricate patterning of active and passive regions, which are difficult to replicate in synthetic matter. Here, we introduce a filament-centric strategy for programmable shape morphing in which intrinsic curvature and twist are directly encoded within multimaterial elastomeric...
• A parallel algorithm for the computation of the Jones polynomial AI翻译
  作者：Barkataki, Kasturi; Panagiotou, Eleni
  作者单位：Arizona State University; Arizona State University-Tempe
  摘要：Knots, links, and entangled filaments appear in many physical systems in biology and engineering and their structural complexity is related to their function. In the context of emerging AI capabilities in predicting new physical structures, as well as in assisting mathematical proofs, the efficient computation of topological invariants and other metrics of entanglement becomes a considerable barrier to scientific advances. The computation of common measures of topological complexity, such as t...
• From Drosophila to mammals: The evolutionarily conserved homeodomain protein Engrailed affects the antitumor innate immune response AI翻译
  作者：Huang, Jieqing; Lan, Xiao; Huang, Xiaoming; Yuan, Yuntong; Liu, Mo; Liu, Jiyong; Chen, Juanjuan; Ye, Zhenhui; Wei, Ziming; Chen, Yuqiang; Deng, Zihao; Zhang, Yuhong; He, Yanzhen; Zhou, Xiaojing; Cao, Zhenming; Jiu, Mengyu; Jiao, Renjie; Cai, Hua; Hoffmann, Jules A.; Chen, Di
  作者单位：Guangzhou Medical University; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; CNRS - National Institute for Biology (INSB); Universite de Strasbourg
  摘要：In the process of investigating innate immune reactions against injected oncogenic cells in Drosophila, we noted that the homeodomain protein Engrailed, known since last century for its role in segmentation polarity in embryos, is reactivated in adult males where it considerably restricts the expected proliferation of these cells. Importantly, this effect was not induced following injection of selected pathogens or primary Drosophila embryonic cells. We show that the injection of these cells i...
• Dopaminergic modulation of the sense of agency influences moral behavior in Parkinson's disease AI翻译
  作者：Ponsi, Giorgia; Villa, Riccardo; Di Vico, Ilaria; Panasiti, Maria Serena; Schepisi, Michael; Tinazzi, Michele; Aglioti, Salvatore Maria
  作者单位：Istituto Italiano di Tecnologia - IIT; Sapienza University Rome; IRCCS Santa Lucia; Ghent University; University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Verona; Sapienza University Rome; University of Verona
  摘要：Embodied accounts of morality propose that corporeal self-awareness helps restrain immoral actions. The Sense of Agency (SoA)-the feeling of controlling one's actions and their consequences-drops when individuals harm others. However, whether modulating SoA shifts moral behavior remains unclear. Parkinson's Disease (PD) offers a unique model to address this question, because dopaminergic dysfunction affects both SoA and moral decision-making. We tested 23 individuals with PD in ON and OFF dopa...
• Halibee member archaeology: Middle Stone Age environment, technology, and postmortem modifications AI翻译
  作者：Beyene, Yonas; Asfaw, Berhane; White, Tim D.; WoldeGabriel, Giday; Bernor, Raymond; Bibi, Faysal; Boisserie, Jean -Renaud; Brasil, Marianne F.; Brochu, Christopher A.; Carlson, Joshua P.; Garcia, Nuria G.; Giaourtsakis, Ioannis X.; Hailu, Haregewin; Hart, William K.; Head, Jason J.; Hlusko, Leslea J.; Kaya, Ferhat; Louchart, Antoine; Melaku, Sahleselasie; Muller, Johannes; Niespolo, Elizabeth M.; Pehlevan, Cesur; Renne, Paul R.; Souron, Antoine; Sanchez-Romero, Laura
  作者单位：University of California System; University of California Berkeley; Centro Nacional de Investigacion de La Evolucion Humana (CENIEH); Smithsonian Institution; Smithsonian National Museum of Natural History; Leibniz Institut fur Evolutions und Biodiversitatsforschung; Centre National de la Recherche Scientifique (CNRS); Universite de Poitiers; CNRS - Institute of Ecology & Environment (INEE); Western Washington University; University of Iowa; Complutense University of Madrid; National & Kapodistrian University of Athens; University System of Ohio; Miami University; University of Cambridge; University of Cambridge; Centro Nacional de Investigacion de La Evolucion Humana (CENIEH); University of Oulu; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); Princeton University; Nevsehir Haci Bektas Veli University; University of California System; University of California Berkeley; Berkeley Geochronolgy Center; Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; CNRS - Institute of Ecology & Environment (INEE); University of Sevilla; University of Sevilla
  摘要：The Middle Awash study area of Ethiopia's Afar Rift features a composite strati-graphic thickness of >1 km. Near the top of this succession lie sediments of the lower Halibee member, comprising the Faro Daba and Chai Baro beds. The former are radioisotopically dated to similar to 100,000 y in age and contain abundant fossils and associated lithic artifacts representing the Middle Stone Age (MSA). Geological, paleontological, and archaeological datasets recovered from these sediments enlarge a ...
• Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms AI翻译
  作者：Costantino, Lorenzo; Ye, Tiantian; Boardman, Kevin; Xiang, Siheng; Luo, Jonathan; Mu, Yudi; Ma, Wenxiu; Koshland, Douglas
  作者单位：University of California System; University of California Berkeley; Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); University of California System; University of California Riverside
  摘要：Cohesin is a conserved protein complex that mediates sister chromatid cohesion, chromosome condensation, gene regulation, and DNA repair. These processes rely on cohesin's ability to tether DNA and form chromatin loops, which depend on cohesin's ATP hydrolysis activity and Eco1-mediated acetylation of two lysines (K112 and K113 in budding yeast) in its Smc3 subunit. However, how cohesin's ATPase activity and acetylation integrate to control cohesin functions in vivo remains poorly understood. ...
• Thinking traces in large reasoning models: Cognitive cost or performative scaffolding? AI翻译
  作者：Hu, Yueqing
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS
• High- resolution present- day Y- chromosome phylogeny refines golden horde lineage placement AI翻译
  作者：Zhabagin, Maxat; Sabitov, Zhaxylyk
  作者单位：JSC National Holding QazBioPharm; National Center for Biotechnology (NCB)
• Cross-linking of collagen fibrils leads to preferential gap zone mineralization in vitro AI翻译
  作者：Gao, Ruixin; DiCecco, Liza -Anastasia; Zhong, Liyang; Wojtas, Magdalena; Carneiro, Karina; Grandfield, Kathryn; Sone, Eli D.
  作者单位：University of Toronto; McMaster University; University of Waterloo; Wroclaw University of Science & Technology; University of Toronto; McMaster University; University of Toronto
  摘要：Collagen mineralization is fundamental to the structure and mechanical properties of bone. Many in vitro models of collagen mineralization have been developed to understand the regulation, from the structure of collagen fibrils to the matrix noncollagenous proteins. However, most models using reconstituted collagen fibrils fail to reproduce preferential gap-zone mineralization, an important hallmark of natively mineralized collagen. This study focuses on the effect of chemical cross-linking on...