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作者：Huang, Ruilin; Wang, Jiurong; Ding, Ruirui; Liu, Yu; Su, Juanjuan; Chen, Zhihang; Fan, Yong; Li, Fuli; Wang, Linqi; Liu, Xiao; Wang, Shi'an
作者单位：Chinese Academy of Sciences; Qingdao Institute of Bioenergy & Bioprocess Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Microbiology, CAS
摘要：Sterols, lipids, and carotenoids are major metabolites that share common biosynthetic precursors and underpin key physiological processes in eukaryotes. Yet, how cells coordinate metabolic flux through these competing pathways to maintain homeostasis remains unclear. Here, we identify a conserved RING-type E3 ubiquitin ligase, PTR1, as a central regulatory hub that orchestrates the interplay among these pathways in the yeast Xanthophyllomyces dendrorhous. Disruption of PTR1 triggers a concerte...
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作者：Kempes, Christopher P.
作者单位：The Santa Fe Institute
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作者：Nuzzi, Davide; Cisek, Paul; Pezzulo, Giovanni
作者单位：Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze e Tecnologie della Cognizione (ISTC-CNR); Universite de Montreal
摘要：Everyday tasks, such as selecting routes when driving or preparing meals, require making sequences of embodied decisions, in which planning and action processes are intertwined. Here, we address how people make sequential embodied decisions, requiring balancing between immediate affordances and long-term utilities of alternative action plans. We designed a virtually embodied task in which participants controlled an avatar tasked with crossing rivers by jumping across rocks. The task permitted ...
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作者：Brosch, Roland
作者单位：Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris
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作者：Fang, Chuantao; Liu, Yi; Zhang, Xiaodan; Wang, Ziwu; Guo, Rongliang; Guo, Jingjing; Liu, Xianming; Tan, Yanfeng; Lu, Hao -jie; Zhao, Rui; Meng, Guilin; Qi, Dashi
作者单位：Tongji University; Fudan University; Tongji University; Universidade de Vigo; Chinese Academy of Agricultural Sciences; Institute of Urban Agriculture, CAAS; Fudan University; Shanghai Jiao Tong University; Hebei University of Engineering; Fudan University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Tongji University
摘要：Focal cortical dysplasia (FCD) is a major cause of drug-resistant epilepsy and displays substantial clinical and histopathological heterogeneity, yet the cellular and molecular bases underlying this diversity remain poorly defined. Here, we performed single-nucleus RNA sequencing of 487,286 nuclei from 34 paired lesional cores and perilesional cortices across FCD I-III, generating a cell-type-resolved transcriptomic atlas of human FCD. Comparative analyses identified both shared and subtype-sp...
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作者：Glawe, Adam J.; Eix, Emily F.; Johnson, Chad J.; Zarnowski, Robert; Andes, Maisy K.; Lazarcik, James; Henzler-Wildman, Katherine A.; Nett, Jeniel E.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：The recently emergent fungal pathogen Candidozyma (Candida) auris has produced numerous outbreaks of invasive disease in hospitals worldwide. It is the first fungal pathogen categorized as a global public health threat due to its ability to readily colonize skin, spread efficiently person-to-person, and cause invasive infection with high mortality. Skin colonization not only promotes healthcare spread but also leads to invasive infection via the insertion of medical devices through skin. Howev...
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作者：Muller, Viktor; Steels, Luc; Szathmary, Ears
作者单位：Eotvos Lorand University; Eotvos Lorand University
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作者：Ukogu, Obinna A.; Montague, Zachary; Altan-Bonnet, Gregoire; Nourmohammad, Armita
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Yale University; Yale University; Yale University; Yale University
摘要：Cytotoxic T lymphocytes eliminate infected or malignant cells, safeguarding surrounding tissues. Although experimental and systems-immunology studies have cataloged many molecular and cellular actors involved in an immune response, the design principles governing how the speed and magnitude of T cell responses emerge from cellular decision-making remain elusive. Here, we recast the T cell response as a feedback-controlled program, wherein the rates of activation, proliferation, differentiation...
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作者：Peters, Bradley J.; Halfar, Marc C.; Rundhaug, Courtney J.; Castillo, Paterno R.; Schonbachler, Maria
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Copenhagen; University of California System; University of California San Diego; Scripps Institution of Oceanography
摘要：Many petrological, geodynamical, and geochemical perspectives have offered circumstantial evidence for either an early onset of plate tectonics in the first 10% of Earth's history or a late onset after the great oxidation event (2.5 Ga ago). This calls into question over what timescales plate tectonics have influenced terrestrial geological and geochemical processes. We present geochemical data from the products of ancient crustal subduction, which were recycled into the deep mantle and then t...
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作者：Furnas, Alexander C.; Wang, Dashun
作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：This study offers a systematic analysis of scientific papers cited in both Republican and congressional reports, hearings, and think tank publications. We find that bipartisan citations, while rare, highlight papers of exceptional scientific influence. Policy documents citing these papers also receive more citations, amplifying their policy impact. Yet, bipartisan- cited science is unevenly distributed-concentrated in monetary policy and healthcare, but notably absent in climate, inequality, a...
