17期

最新文章

• Stretchable large-area transparent nanowire composite arrays for label-free multimodal interrogation of cardiac physiology AI翻译
  作者：Quirion, Nathaniel T.; Alber, Bridget R.; Dong, Chenghe; Fehr, Amy; Zhao, Qinai; Shields, Nora; Yang, Ze; Zhao, Hangbo; Kay, Matthew W.; Lu, Luyao
  作者单位：George Washington University; University of Southern California; University of Southern California; University of Southern California
  摘要：Simultaneous interrogation of cardiac electrophysiological and metabolic processes is essential for investigating and treating heart disease. Key challenges remain in creating stretchable multimodal bioelectronic devices capable of organ-scale, label-free probing of electrophysiology and metabolism in vivo. Here, we present stretchable, scalable, large-area transparent microelectrode arrays (MEAs) that integrate up to 144 microelectrodes and interconnects, enabling a centimeter-scale field of ...
• Loss of UFL1 drives chromosome instability and tumorigenesis of prostate cancer AI翻译
  作者：Li, Jimin; Yang, Fang; Zhang, Xiao; Xu, Liangfei; Zheng, Hui; Liu, Liu; Wan, Xin; Xu, Tao; Jiang, Guanmin; Wang, Hao
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Wannan Medical University; Chinese People's Liberation Army General Hospital; Anhui Medical University; Sun Yat Sen University
  摘要：Chromosomal instability (CIN) is a prevalent form of genomic instability in prostate cancer (PCa). However, its molecular mechanisms remain inadequately understood. This study demonstrates that reduced expression of UFM1-ligase 1 (UFL1) is commonly observed in PCa and correlates with elevated CIN rates. UFL1 deficiency results in severe mitotic defects, errors in chromosome segregation, and aneuploidy, thereby promoting malignant transformation. Mechanistically, UFL1 interacts with RNF20 and c...
• Learn from the blame game when AI causes harm AI翻译
  作者：Killoran, Jay; Park, Andrew
  作者单位：University of Victoria
• Ice amplifies ligand-controlled mineral dissolution in microscale hot spots AI翻译
  作者：Chen, Tao; Luo, Tao; Thi, Tra My Bui; Colloc, Herve; Roiland, Claire; Le Polles, Laurent; Hanna, Khalil; Boily, Jean-Francois
  作者单位：Umea University; Centre National de la Recherche Scientifique (CNRS); Universite de Rennes; Ecole Nationale Superieure de Chimie de Rennes (ENSCR); CNRS - Institute of Chemistry (INC)
  摘要：Cold-region ecosystems are highly sensitive to climate change, yet the geochemical processes shaping their future remain poorly understood. Here, we show that ice systematically enhances mineral dissolution through freeze concentration into microscale reactive hot spots. Using goethite nanoparticles as a model iron oxide and environmentally relevant inorganic anions common in soils, waters, and aerosols (chloride, fluoride, sulfate), we demonstrate that ligand-promoted dissolution rates under ...
• Uncoupling neocortical neuron fate and migration via a Let-7-RBX2 axis AI翻译
  作者：Decker, Steven C.; Hino, Keiko; La Torre, Anna; Simo, Sergi
  作者单位：University of California System; University of California Davis
  摘要：Throughout the central nervous system, the fate and migration of projection neurons (PNs) are tightly coordinated to ensure that specific neuronal fates settle in precise spatial locations. This is particularly evident in the mammalian neocortex, where early-born PNs predominantly remain in the deeper layers of the cortical plate, whereas later-born neurons localize more superficially. However, it remains unclear whether neuronal fate acquisition directly primes the molecular mechanisms drivin...
• Monoclonal antibodies against nitrated nerve growth factor reveal an oxidation-dependent pathogenic hallmark in ALS AI翻译
  作者：Varela, Valentina; Garcimartin, Santiago; Trias, Emiliano; Zeida, Ari; Richter, Monique; de Leon, Andres; Miquel, Ernesto; King, Peter H.; Vulliez-Le Normand, Brigitte; Martinez, Mariano; Alzari, Pedro M.; Bartesaghi, Silvina; Radi, Rafael; Barbeito, Luis
  作者单位：Pasteur Network; Institut Pasteur de Montevideo; Universidad de la Republica, Uruguay; Universidad de la Republica, Uruguay; Universidad de la Republica, Uruguay; Universidad de la Republica, Uruguay; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris
  摘要：Nerve growth factor (NGF) is a member of the neurotrophin family, essential for neuronal survival and phenotypic maintenance. However, in vitro, its function can be disrupted by oxidative posttranslational modifications such as tyrosine nitration. Nitrated NGF (NO2NGF) has been shown to have a gain-of-toxic, pro-apoptotic, activity in motoneuron cultures. Herein, we report the generation and characterization of monoclonal antibodies (mAbs) that specifically recognize NO2NGF to unravel its form...
• Machine learning multiscale collective cell dynamics: From single-cell characterization to multicellular monolayer modeling AI翻译
  作者：Xu, Kun; Bai, Jianbo; Zhang, Hao-Shun; Lv, Cheng-Lin; Li, Yue; Shao, Yue; Feng, Xi-Qiao; Li, Bo
  作者单位：Tsinghua University; Tsinghua University; Tsinghua University
  摘要：Collective cell dynamics are fundamental to numerous physiological processes, including embryo development, tissue morphogenesis, immune response, and disease progression. Accurately modeling these dynamics across scales remains challenging, as traditional physics-based models usually rely on many unmeasurable parameters and unclear active physics, limiting their ability to capture both single-cell features and emergent multicellular behaviors. Here, we introduce a scale-adaptive hybrid machin...
• Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors AI翻译
  作者：Brown, David A.; Koll, Katja K.; Brush, Erin; Darner, Grant; Curtis Jr, Timothy; Dvergsten, Thomas; Tran, Melissa; Milligan, Colleen; Wolfson, David W.; Gonzalez, Trevor J.; Jeffs, Sydney; Ehrhardt, Alyssa; Bitolas, Rochelle; Landau, Madeleine; Reitz, Kendall; Salven, David S.; Slota-Burtt, Leslie A.; Snee, Isabel; Singer-Freeman, Elena; Bhatia, Sayuri; Ou, Jianhong; Asokan, Aravind; Currie, Joshua D.; Poss, Kenneth D.
  作者单位：Duke University; Ruprecht Karls University Heidelberg; Duke University; Wake Forest University; Duke University; Duke University; Tulane University; Georgetown University; Duke University; University of Wisconsin System; University of Wisconsin Madison; The Morgridge Institute for Research, Inc.; University of Wisconsin System; University of Wisconsin Madison; Wake Forest University
  摘要：Limb loss remains a significant clinical challenge, but regenerative medicine approaches such as gene therapy offer a promising strategy to trigger endogenous regeneration programs. Optimal vector configurations and molecular targets for appendicular skeletal repair are not well defined. Here, we leveraged insights from species with a high endogenous capacity for appendage regeneration to design an enhancer-directed gene delivery platform that functions during mouse digit regeneration, a well-...
• Connecting habitats, boosting disease resistance: Spatial connectivity enhances amphibian microbiome defenses against fungal pathogen AI翻译
  作者：Medina, Daniel; Martins, Renato A.; Prist, Paula R.; Buttimer, Shannon; Neely, Wesley J.; Schuck, Laura K.; Greenspan, Sasha E.; Lyra, Mariana L.; Kearns, Patrick J.; Woodhams, Douglas C.; Bletz, Molly C.; Sao-Pedro, Vinicius A.; Haddad, Celio F. B.; Becker, C. Guilherme
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Universidade Estadual Paulista; EcoHealth Alliance; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Texas State University System; Texas State University San Marcos; Kennedy Krieger Institute; New York University; New York University Abu Dhabi; University of Massachusetts System; University of Massachusetts Boston; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Universidade Federal de Sao Carlos
  摘要：Disruption of habitat connectivity alters host movement patterns and pathogen exposure in wildlife. Changes in exposure dynamics have led to increased research interest in host-associated microbial communities (i.e., microbiomes), particularly in how repeated encounters with pathogens may drive microbial filtering processes that favor the assembly of pathogen-inhibiting microbiomes, a concept known as the adaptive microbiome principle. Understanding how habitat connectivity and pathogen exposu...
• Masculinization of populations reverses sex differences in fertility AI翻译
  作者：Schubert, Henrik-Alexander; Spoorenberg, Thomas; Dudel, Christian; Skirbekk, Vegard Fykse
  作者单位：Max Planck Society; Norwegian Institute of Public Health (NIPH); University of Oslo
  摘要：Reproductive-age populations show a growing male surplus around the globe as a consequence of declining mortality, narrowing sex differences in mortality, and sex-selective abortions in some countries. Population structures are important determinants of marriage markets and childbearing. In this study, we estimate the past, current, and future difference between the male and the female total fertility rates around the world using an established indirect demographic approach drawing on data fro...