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作者：Guo, Ruipeng; Pan, Xueli; Deng, Qilin; Ahmed, Abrar; Yang, Qianwan; Greene, Joseph; Li, Tongyu; Chan, Suet Ying; Chen, Zhixiong; Hu, Guorong; Feng, Hui; Tian, Lei
作者单位：Boston University; Boston University; Boston University; Boston University
摘要：Many fundamental biological processes-spanning immune-tumor interactions, neuronal signaling, and microvascular flow-exhibit fast, multiscale dynamics among diverse cell types within three-dimensional tissue environments. Capturing such activity requires imaging systems that simultaneously achieve high temporal resolution, multicolor capability, and large axial coverage over large fields of view (FOVs). However, existing modalities remain limited by trade-offs among imaging speed, spectral cap...
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作者：van der Vleuten, Maaike; Kalmijn, Matthijs
作者单位：Royal Netherlands Academy of Arts & Sciences; University of Groningen; Netherlands Interdisciplinary Demographic Institute (NIDI-KNAW); Stockholm University
摘要：Women in different-sex couples experience larger economic losses after separation than men, largely due to unequal divisions of paid and unpaid work. Women in female same-sex couples divide paid and unpaid work more equally, offering a unique opportunity to examine how partner sex, parenthood, and giving birth shape women's economic outcomes after separation. Using Finnish population register data (2002-2020), we analyze 1,157 women in same-sex couples and 67,384 women in different-sex couples...
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作者：Borman, Geoffrey D.; Yang, Hyunwoo
作者单位：Arizona State University; Arizona State University-Tempe; Chinese University of Hong Kong
摘要：For more than a century, studies have shown that children who grow up in homes with more books achieve higher levels of academic success, yet it remains unclear whether books themselves improve learning or simply reflect broader socioeconomic advantages. Skill-development theory holds that greater access to books directly improves literacy through increased print exposure and reading practice, whereas the cultural capital account suggests books are indicators of broader family resources, inclu...
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作者：Colomer-Winter, Cristina; Nair, Zeus J.; Chua, Jerome Y. J.; Jabli, Soukayna; Roch, Melanie; Cazenave-Gassiot, Amaury; Sierra, Roberto; Andrey, Diego O.; Chng, Shu-Sin; Kline, Kimberly A.
作者单位：University of Geneva; National University of Singapore; Nanyang Technological University; Massachusetts Institute of Technology (MIT); Nanyang Technological University; National University of Singapore; National University of Singapore; University of Geneva; University of Geneva; University of Geneva; National University of Singapore; National University of Singapore; Nanyang Technological University
摘要：Daptomycin is a last resort antibiotic used to treat vancomycin-resistant enterococcal infections, but daptomycin resistance (DAPR) arises quickly during treatment. Resistance is due to sequential acquisition of point mutations in the two-component system LiaFSR and in cardiolipin synthases and is associated with alteration of phospholipid and glycolipid membrane composition. The molecular mechanisms underlying these lipid changes are currently unknown. Similarly, it is unclear why mutations i...
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作者：Harris, Mariana; Mo, Ziyi; Siepel, Adam; Garud, Nandita R.
作者单位：University of California System; University of California Los Angeles; Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA
摘要：The extent to which human adaptations have persisted throughout history despite strong eroding demographic events such as admixture, genetic drift, and fluctuations in selection pressures remains unknown. Understanding which adaptations were resilient to such forces may shed light on traits that were important for humans across time. Yet, detecting selection from ancient DNA is challenging due to severe degradation of the data and/or signal. Here we detect selective sweeps using a domain-adapt...
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作者：Robay, Dimitri; Ackermann, Ole; Laborde, Laurent; Shi, Xingyi; Oreglia, Federico; Stump, Ramona; Ciaghi, Sabina; Galli, Giorgio G.; Holzer, Laura; Villemin, Lorraine; Wagner, Joel; Wu, Jincheng; Lee, Lang Ho; Bossen, Claudia; Mourikis, Thanos P.; Gabriel, Millicent; Ruddy, David; Yu, Haiyan; Johannessen, Cory; Ferretti, Stephane; Costa, Carlotta
作者单位：NYU Langone Medical Center; New York University; Novartis; Novartis
摘要：Non-small cell lung cancer (NSCLC) patients with tumors harboring STK11 mutations are resistant to standard of care anti-PD-1/PD-L1 blockade. For this patient population there are no currently available tailored treatments, underlying the critical need to discover effective therapeutic strategies. In this study, we dissected the molecular mechanisms responsible for STK11-mediated resistance to immune checkpoint blockade (ICB) and identified CRTC2, a coactivator of the transcription factor cAMP...
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作者：Hong, Xupeng; Brousseau, Georgia; Chen, Hsuan- An; Freije, Catherine A.; Seifert, Leon L.; Zhang, Mengyin; Yu, Yingpu; Schneider, William M.; de Jong, Ype P.; McLachlan, Alan; Rice, Charles M.
作者单位：Rockefeller University; Cornell University; Weill Cornell Medicine; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：Chronic hepatitis B virus (HBV) infection affects nearly 300 million people worldwide. Progress in understanding HBV immunopathogenesis and developing curative therapies has been hindered by the lack of suitable small animal models. HBV exhibits strict host and tissue tropism, with productive infection largely restricted to human and chimpanzee hepatocytes. Murine hepatocytes are resistant to HBV infection, even with ectopic expression of the human HBV entry receptor sodium taurocholate cotran...
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作者：Krachler, Anne Marie
作者单位：University of Texas System; University of Texas Health Science Center Houston
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作者：Lu, Hengfa; Fang, Qingwei; Ashbrook, Jewel A.; Nemchek, Victoria; Fracassi, Michela; Jones, Theresa A.; Dunn, Andrew K.
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
摘要：Measuring fast dynamic processes with dynamic light scattering over wide fields of view is critical for applications ranging from blood flow imaging to characterizing complex fluids, yet is often limited by the need for expensive, high frame rate cameras. Here, we introduce sinusoidal intensity modulation speckle imaging (SIMSI), a technique that overcomes this hardware limitation by encoding information about fast dynamics into images captured with long camera exposures. Within each exposure,...
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作者：Miyano, Rinako; Onishi, Taichi; Tabuchi, Eri; Hirose, Kenzo; Sakaba, Takeshi
作者单位：Doshisha University; University of Tokyo
摘要：Synaptic strength is dynamically modulated not only by activity-dependent processes but also by neuromodulators. These modulators can enhance or depress synaptic transmission and play essential roles in circuit function and in the pathophysiology of psychiatric disorders. Although neuromodulation is functionally important in vivo, the underlying cellular mechanisms-particularly at the presynaptic site-remain poorly understood in mammalian synapses because of the difficulty in obtaining direct ...
