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作者：Du, Xiao-Min; Suo, Fang; Du, Li-Lin
作者单位：Beijing Normal University; National Institute of Biological Sciences, Beijing; Tsinghua University
摘要：Natural variation in metabolism is a key driver of microbial adaptation. While galactose utilization is well studied in budding yeasts, it remains poorly understood in the fission yeast Schizosaccharomyces pombe. Here, we reveal extensive natural variation in galactose utilization across S. pombe isolates-from complete deficiency (Gal-) to exceptionally fast growth (GalF). Gal-strains fall into two classes: one with deletions of the gal gene cluster (via three distinct mechanisms) and another ...
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作者：Kong, Lingyu; Zhong, Fumei; Yu, Fazhi; Wang, Ting; Wang, Gang; Bai, Yu; Xia, Han; Pan, Zihang; Liu, Mingxue; Zhang, Yan; Feng, Rui; Zhang, Jiahai; Du, Yingying; Zhang, Kaiguang; Guo, Jing; Ruan, Ke; Yang, Zhenye
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Guangzhou Medical University; Guangzhou Institute of Biomedicine & Health, CAS; Anhui Medical University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：The mitotic kinase Aurora-A is frequently overexpressed in cancers and contributes to tumor progression and therapy resistance, yet the mechanisms underlying its role in drug resistance remain unclear. Here, we show that sorafenib treatment triggers Aurora-A phase separation, leading to its recruitment into stress granules (SGs), membraneless organelles that promote cancer cell survival. Aurora-A facilitates robust SGs assembly, thereby conferring sorafenib resistance. Mechanistically, upon so...
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作者：Roy, Bhaskar; Obaid, Abeer H.; Wang, Zhenjian; Kovacs, Kristof G.; Ohashi, Sarah; Kalayci, F. Naz Cemre; Joo, Daniel; Masi, Gianvito; Coppola, Carmina; Das, Sameeran; Hernandez, Amanda L.; Martin-Aguilar, Lorena; Lleixa, Cinta; Nowak, Richard J.; Querol, Luis; O'Connor, Kevin C.
作者单位：Yale University; Yale University; Hacettepe University; Hospital of Santa Creu i Sant Pau; Institut de Recerca Sant Pau (IR SANT PAU); CIBER - Centro de Investigacion Biomedica en Red; CIBERER
摘要：Autoimmune nodopathies (AINs) are rare acquired autoimmune neuropathies with distinct clinical features and circulating autoantibodies, often of the immunoglobulin G4 (IgG4) subclass, targeting proteins at the node of Ranvier. Defects in B cell tolerance checkpoints have been implicated in several autoimmune diseases, including MuSK-positive myasthenia gravis, another IgG4 autoantibody-mediated disease. Here, we investigated whether tolerance defects exist in neurofascin-155-mediated AIN (NF15...
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作者：Sikora, Maciej; Mozajew, Mariusz; Sikorska, Julia A.; da Silva, Fernando Bruno; Perlinska, Agata P.; Kluza, Anna; Niewieczerzal, Szymon; Lukaszewicz, Maciej; Wielgus-Kutrowska, Beata; Stachurska-Korzeniowska, Karolina; Jackson, Sophie E.; Sulkowska, Joanna I.
作者单位：University of Warsaw; University of Warsaw
摘要：Herein, we present crystal structures of proteins adopting a fold not identified among known /3-solenoids in current structural databases, a Knotted Solenoid. These proteins exhibit a characteristic solenoidal architecture, closely resembling /3-solenoid proteins. However, a unique skip-and-backtrack shift is observed: One coil skips a rotation while the next realigns, distinguishing this fold from previously described solenoids and allowing the formation of a 31 (trefoil) knot. Moreover, the ...
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作者：Davis, Matthew W.; Leslie, Charles A.; Lee, Chaehee; Long, Evan; Meinhold, Li; Lorenc, Megan; Lewis, Franklin; Brown, Patrick J.; Monroe, Grey
作者单位：University of California System; University of California Davis; United States Department of Agriculture (USDA)
摘要：Many plants, unlike most animals, can reproduce as clones [D. Kester, HortScience 18, 831-837 (1983), 10.21273/hortsci.18.6.831]. Cloning plants is vital to agriculture and biotechnology [H. Barton, T. Denham, Quatern. Int. 489, 17-25 (2018), O. L. Gamborg, In Vitro Cell. Dev. Biol. Plant 38, 84-92 (2002), K.-H. Neumann, A. Kumar, J. Imani, Plant Cell and Tissue Culture-A Tool in Biotechnology: Basics and Application (ed. 2, 2020)], but the extent to which somatic mutation arises during asexua...
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作者：Jing, Fei; Zhang, Zi-Ke; Zhang, Qingpeng; Parisi, Giorgio
作者单位：University of Hong Kong; University of Hong Kong; Zhejiang University; Beihang University; Qinghai Normal University; Sapienza University Rome
摘要：We establish network predictability theory by mapping link prediction onto a spin glass model, where network partitions correspond to spin configurations, and predictability equals the system's average energy. Using the cavity method from statistical physics, we prove that global predictability decomposes into individual link contributions, enabling an efficient local sampling algorithm that reduces the computational complexity of evaluating individual link contributions from being dependent o...
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作者：Lei, Yuanyuan; Wei, Zhijun; Ye, Kaiye; van Groenigen, Kees Jan; Liu, Yu; Cui, Hongna; Butterbach-Bahl, Klaus; Smith, Pete; Chen, Deli; Lam, Shu Kee; Horwath, William R.; Amelung, Wulf; Ti, Chaopu; Zhou, Wei; Yang, Jingrui; He, Hongbo; Zhang, Xudong; Zhou, Sheng; Yan, Xiaoyuan; Xia, Longlong
作者单位：Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Exeter; Aarhus University; Helmholtz Association; Karlsruhe Institute of Technology; University of Aberdeen; University of Melbourne; University of California System; University of California Davis; University of Bonn; Helmholtz Association; Julich Research Centre; Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; Shanghai Academy of Agricultural Sciences
摘要：Rice production underpins food security but relies heavily on nitrogen (N) fertilization, much of which is lost as gaseous emissions. Dinitrogen (N-2) represents the largest N loss, yet its sources remain poorly constrained because biological dinitrogen (N-2) fluxes are difficult to quantify against the atmospheric background. Here, we apply an in situ N-15 tracing-membrane inlet mass spectrometry (N-15-MIMS) technique to simultaneously measure N-2, ammonia (NH3), and nitrous oxide (N2O) emiss...
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作者：Rao, Nishant; Gendron, Rosalie; Manning, Timothy F.; Ostry, David J.
作者单位：Yale University; McGill University
摘要：Changes to speech offer a quantifiable means to assess speech motor learning, and the resulting memory is thought to be motor in nature. Here, we evaluate this idea and show instead that memory for speech movements has a sensory basis. Speech motor learning, using altered auditory feedback, provides an experimental model to address this question as it involves auditory, somatosensory, and motor components to learning. Transcranial magnetic stimulation was used to disrupt auditory (superior tem...
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作者：Zhao, Jian; Ardiel, Evan; Nurrish, Stephen; Kaplan, Joshua M.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Western Washington University; Harvard University; Harvard Medical School
摘要：Polyadic synapses (where each active zone is juxtaposed with multiple postsynaptic targets) are found in many brain regions and are implicated in learning and memory, yet little is known about how they function. To address this question, we analyze Caenorhabditis elegans cholinergic (ACh) motor neurons, which form dyadic synapses tors in either target elicits a retrograde decrease in presynaptic type 2 voltage-activated calcium channels (CaV2), thereby decreasing ACh release. By contrast, bloc...
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作者：Erren, Thomas C.; Lewis, Philip; Morfeld, Peter
作者单位：University of Cologne; University of Cologne
