-
作者：Ivanich, Jerreed D.
作者单位：University of Colorado System; University of Colorado Anschutz; Colorado School of Public Health
-
作者：Wells, Chad R.; Pandey, Abhishek; Ye, Yang; Bawden, Carolyn; Giglio, Rebecca; Wong, Charlene; Wang, Velda; Cipriano, Chelsea; Ayaz, Lamia; Rost, Gergely; Moghadas, Seyed M.; Fitzpatrick, Meagan C.; Singer, Burton H.; Galvani, Alison P.
作者单位：Yale University; Szeged University; York University - Canada; University System of Maryland; University of Maryland Baltimore; State University System of Florida; University of Florida
摘要：The resurgence of measles in the United States, driven by declining childhood vaccination coverage, poses a substantial public health and economic threat. Using county-level Measles-Mumps-Rubella (MMR) vaccine coverage data and spatial incidence models, we quantified the economic burden of measles in 2025 and projected the impact of continued declines in vaccine uptake. In 2025, the estimated cost per measles case was $104,629 [50% high-density interval (HDI): $100,729 to $110,140], yielding a...
-
作者：Kwarcinski, Frank E.; Bernadyn, Tyler F.; Teuber, James P.; Nascimento, Mariane; Bergin, Ingrid; Shen, Tingzhen; Gandhi, Riya; Lu, Xinyi; Brody, Matthew J.; Holinstat, Michael; Tall, Gregory G.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Adhesion G protein-coupled receptors (AGPCRs) regulate essential physiological processes through interactions between their ectodomains and adjacent cell surface proteins or extracellular matrix components (ECM). AGPCRs distinctively arrive at the plasma membrane as self-cleaved holoreceptors with noncovalently associated N-terminal (NTF) and C-terminal fragments (CTF). Canonical AGPCR signaling proceeds in three sequential steps; NTF adhesive domains bind to ligands, extracellular shear force...
-
作者：Kadyrova, Lyudmila Y.; Kadyrov, Farid F.; Hayward, Bruce; Usdin, Karen; Kadyrov, Farid A.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Southern Illinois University System; Southern Illinois University; Washington University (WUSTL); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
摘要：MutS and MutL proteins and their eukaryotic homologs have important functions in DNA metabolism. MutL beta (MLH1-PMS1 heterodimer) is a poorly understood eukaryotic MutL complex. Recent genetic studies have implicated MutL beta in the process of expansion of the short, tandem DNA repeat tracts that is responsible for the repeat expansion diseases. The function of MutL beta and the mechanism of MutL beta-dependent DNA expansions have not been established. We show here that MutL beta promotes Mu...
