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作者：Canner, Samuel W.; Schnaar, Ronald L.; Gray, Jeffrey J.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University
摘要：Noncovalent interaction between proteins and carbohydrates (sugars, glycans) is the basis for biological functions from metabolic regulation to intercellular recognition. It is a grand challenge to identify the protein-carbohydrate interactomes in organisms. Direct experiments would require extensive libraries of glycans to distinguish binding from nonbinding proteins. Computational screening of proteins for carbohydrate binding potential provides an attractive alternative. Current estimates p...
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作者：Glaubitz, Alina; Fu, Feng
作者单位：Dartmouth College; Dartmouth College
摘要：Understanding the origins of volunteerism and free-riding is crucial in collective action situations where a sufficient number of cooperators is necessary to achieve shared benefits, such as in vaccination campaigns and social change movements. Despite the importance of attaining behavioral consistency for successful collective action, the theoretical mechanisms behind this process remain largely elusive. Here, we address this issue by studying the evolutionary dynamics of individual cooperati...
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作者：Meincke, Lennart; Shapiro, Dan; Duckworth, Angela L.; Mollick, Ethan; Mollick, Lilach; van den Bulte, Christophe; Cialdini, Robert
作者单位：University of Pennsylvania; WHU - Otto Beisheim School of Management; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Arizona State University; Arizona State University-Tempe
摘要：Are large language models (LLMs) susceptible to the same persuasive appeals as humans? We tested whether classic persuasion principles (authority, commitment, liking, reciprocity, scarcity, social proof, and unity) could induce three widely used LLMs (GPT-5 mini, Claude Haiku 4.5, and Gemini 3 Flash) to comply with requests to assist with the synthesis of regulated substances. Across 126,000 conversations, persuasion principles increased compliance from 35.3% (at baseline) to 51.3% (using any ...
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作者：Yang, Kaiqiao; Nishiwaki, Kazuya; Mizobata, Hideaki; Liang, Jiancheng; Asakawa, Shuichi; Yoshitake, Kazutoshi; Watanabe, Yuuki Y.; Hussey, Nigel E.; Kovacs, Kit M.; Lydersen, Christian; Kadota, Mitsutaka; Kuraku, Shigehiro; Kinoshita, Shigeharu
作者单位：University of Tokyo; Kitasato University; Graduate University for Advanced Studies - Japan; University of Windsor; Norwegian Polar Institute; RIKEN; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Graduate University for Advanced Studies - Japan
摘要：The Greenland shark (Somniosus microcephalus) is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 +/- 120 y. Despite its remarkable longevity and unusual lifestyle, no genomic studies are yet available for this species. Here, we report a chromosome-level assembly of the Greenland shark genome, which is 5.9 Gb in size with an N50 length of 233 Mb and a completeness score of 96.7%. Our analyses of gen...
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作者：Ortiz-Rodriguez, Maria; Singh, Saurabh P.; Cao-Garcia, Francisco J.; Galletto, Roberto; Ibarra, Borja
作者单位：Washington University (WUSTL); Complutense University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional de Biotecnologia (CNB)
摘要：Pif1-family helicases are essential for proper nuclear and mitochondrial genome maintenance, yet the regulation of their activities remains incompletely understood. Here, we use single-molecule manipulation and visualization techniques to dissect the real-time mechanochemical behavior of Pfh1, the sole Pif1-family helicase in Schizosaccharomyces pombe. We systematically varied force, ATP concentration, fork composition, and the single-stranded DNA-binding protein spRim1, to quantify the unwind...
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作者：Shin, Sang-Yoon; Park, Minsu; Lee, Jaehoon; Lee, Seunga; Frost, Jennifer M.; Fischer, Robert L.; Choi, Yeonhee; Shin, Chanseok
作者单位：Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); University of London; King's College London; University of California System; University of California Berkeley
摘要：The Cape Verde Island (Cvi)-0 ecotype, a relict lineage of Arabidopsis thaliana, is characterized by exceptionally low CG methylation levels genome-wide. Numerous population-level and molecular studies have highlighted links between this epigenomic feature, phenotypic traits and environmental factors; however, the molecular mechanism underlying Cvi-0's distinctive methylation profile remains unknown. Using multiomics comparisons between Cvi-0 and Col-0, we identified Cvi-specific small-RNAs de...
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作者：Zhang, Wanwan; Sun, Bingbing; Huang, Hao; Chen, Junyu; Liang, Ying'an; Li, Wenxi; Peng, Qinyu; Zhang, Ping; Zhan, Zhipeng; Yang, Xiaogang; Yao, Lan; Chen, Huiquan; Bacharach, Eran; Li, Haifeng; Guo, Changjun; Yi, Meisheng; Jia, Kuntong
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作者：Gong, Maohua; Zhen, Qiutong; Tang, Yujie; Hu, Peng; Tu, Qing-An; Meng, Yan; Zhou, Peiheng; Gao, Zhen
作者单位：Southern University of Science & Technology; University of Electronic Science & Technology of China; Chongqing University of Technology; Beijing Institute of Technology
摘要：Chiral bound states in the continuum (BICs) are confined photonic modes with infinite quality factors and chiral response, offering significant potential for chiral optics. Although a novel type of spin-orbital-locking chiral BIC was recently predicted in magneto-optical (MO) photonic crystals (PhCs) that break time-reversal symmetry (TRS), its experimental realization has remained elusive. Here, we report an experimental observation of such chiral BICs in self-biased MO PhCs, which operate wi...
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作者：Jana, Anirban; Tauber, Justin; Boyreau, Adeline; Gurchenkov, Basile; Recher, Gaelle; Feyeux, Maxime; Alessandri, Kevin; Nassoy, Pierre; Mahadevan, L.
作者单位：Universite de Bordeaux; Harvard University; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; CNRS - Institute of Physics (INP); Harvard University; Harvard University
摘要：Epithelial cortinoids, fluid-filled shells formed from induced pluripotent stem cells (iPSCs), must accommodate large deformations during growth and morphogenesis. Using inflation-deflation assays and high-resolution imaging, we find that these fluid-filled shells are weakly pressurized and achieve extreme deformability through reversible soft modes of deformation accommodated by the cytoskeleton. We show that cytoskeletal elements such as actin localized along lateral cell edges undergo tilt ...
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作者：Zhang, Jiachen; Zhang, Xinghai; Yao, Yanfeng; Zhou, Junhui; Chen, Da; Shen, Yanqiong; Gong, Qizan; Li, Zhihao; Zhou, Zunhao; Li, Entao; Li, Fangxu; Cheng, Zekai; Liu, Yang; Wang, Weiqi; Liu, Hang; Chen, Miaoyu; Zhang, Huajun; Wang, Chao; Wang, Yucai; Chiu, Sandra
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Several orthoebolaviruses have been established, including Orthoebolavirus zairense [for Ebola virus (EBOV)], Orthoebolavirus sudanense [for Sudan virus (SUDV)], and Orthoebolavirus bundibugyoense [for Bundibugyo virus (BDBV)]. Orthoebolaviruses are highly virulent pathogens that cause severe disease in humans. However, most existing vaccines primarily target EBOV, and fail to provide robust cross-protection against other lethal orthoebolaviruses. The development of a broad-spectrum vaccine ha...
