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作者：Hummer, Robert A.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
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作者：Kunst, Jonas R.; Besta, Tomasz; Obaidi, Milan
作者单位：BI Norwegian Business School; Fahrenheit Universities; University of Gdansk; University of Copenhagen
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作者：Li, Boyan; Mitchison, Timothy J.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：Many small-molecule antitumor drugs are administered far less frequently than would be predicted from their plasma half-lives, in part because their efficacy is driven by prolonged retention within tumors. Drug retention can be caused by nonspecific protein binding, low membrane permeability, sequestration in acidic compartments, slow target dissociation, and rebinding to empty target sites, but the field has lacked a quantitative framework and preclinical assays for discriminating these mecha...
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作者：Boucherie, Louis; Kumar, Sagar; Ledebur, Katharina; Lohse, August; Sliwa, Karolina
作者单位：Technical University of Denmark; University of Copenhagen; Northeastern University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Medical University of Vienna; Aarhus University; Vienna University of Economics & Business
摘要：Beauty standards shape self-perception and health through social comparison and objectification, while exposure to idealized imagery exacerbates body-image concerns. Media and fashion are central arbiters of these ideals, yet long-term, quantitative, intersectional studies on how representation has changed remain scarce. We assembled a dataset of 793,199 records spanning 25 y of advertising, magazine covers, runway shows, and editorials to quantify changes in anthropometric and demographic rep...
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作者：He, Xueting; Aikawa, Shizu; Fukui, Yamato; Ishizawa, Chihiro; Shimizu-Hirota, Ryoko; Hiratsuka, Daiki; Hiraoka, Takehiro; Matsuo, Mitsunori; Hirota, Yasushi
作者单位：University of Tokyo; University of Tsukuba; Keio University
摘要：The uterine microenvironment is critical for establishing pregnancy and sustaining embryonic development. Embryo attachment induces profound endometrial transformation, including stromal differentiation and vascularization, termed decidualization. This process, conserved in humans and rodents, supports the embryo even before placentation. Poorly formed decidua leads to fetal growth restriction or placental defects, yet underlying mechanisms remain unclear. Here, we used single-cell RNA-seq of ...
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作者：Kippes, Nestor; Lieberman, Meric C.; Culp, Darrin; DeMarco, Isabelle J.; Tsai, Helen T.; Masuda, Kanae; Terzaroli, Niccolo; Lopez, Jordan; Wilson, Robert G.; Comai, Luca; Henry, Isabelle M.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of Perugia; Mars; Chulalongkorn University
摘要：Mutations that arise in the shoot apical meristems can become fixed, but typically only in one of the meristem layers. Therefore, in long-lived, clonally propagated species, polymorphic genomes coexist in the form of periclinal chimeras. Given their evolutionary and economic impact, it is critical to understand the dynamics and phenotypic implications of layer-specific variation. Here, we gamma-irradiated axillary buds from an elite peppermint clone and obtained 261 independent mutants carryin...
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作者：Polasky, Stephen; Nelson, Erik; Tilman, David; Gerber, James; Johnson, Justin Andrew; Corong, Erwin; Isbell, Forest; Hill, Jason; Packer, Craig
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Bowdoin College; Purdue University System; Purdue University; University of Minnesota System; University of Minnesota Twin Cities
摘要：As one of the main causes of habitat loss, agricultural cropland expansion is a major threat to biodiversity. We analyze past and anticipated future trends in population, per capita crop demand, and crop yield to estimate agricultural cropland requirements globally by 2050 and 2100, assuming moderate levels of climate change. According to a model of business as usual, higher-income countries would be expected to show little or no net growth in cropland by the end of the century whereas croplan...
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作者：Rott, Niklas; Almond, Douglas; Giuntella, Osea
作者单位：University of Augsburg; Columbia University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Rapid growth of wind energy plays a key role in global efforts to reduce carbon emissions, yet public concerns persist about its potential health effects, particularly through noise exposure. While some studies and media reports suggest that wind turbines may contribute to sleep disturbances, anxiety, and even suicide, existing evidence remains limited and inconclusive. This study combines geolocated data on turbines from the US Wind Turbine Database with longitudinal survey data on over 120,0...
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作者：Alexeev, Boris; Mixon, Dustin G.
作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
摘要：We resolve a $1,000 Erd & odblac;s prize problem, complete with formal verification generated by a large language model. In over a dozen papers, beginning in 1976 and spanning two decades, Paul Erd & odblac;s repeatedly posed one of his favorite conjectures: every finite Sidon set can be extended to a finite perfect difference set. We establish that {1, 2, 4, 8, 13} is a counterexample to this conjecture. During the preparation of this paper, we found that although this problem was presumed to...
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作者：Hall, Matthew E. K.; Leigh, B. Tyler; Solomon, Brittany C.
作者单位：University of Notre Dame; University of Notre Dame
摘要：Most Americans claim to support freedom of speech, including President Donald Trump who has portrayed himself as an ardent defender of this constitutional right. However, in the wake of Charlie Kirk's assassination, Trump and members of his administration began to explicitly call for speech restrictions. This largely unprecedented rhetoric from a sitting president and his allies provides an opportunity to examine competing theories of public opinion: the influence of partisan elites versus the...
