21期

最新文章

• HIV-1 Vif-dependent SUMOylation regulates viral RNA splicing AI翻译
  作者：Tripathi, Shraddha; Wu, Li
  作者单位：University of Iowa
• Dynamic bidirectional coupling of membrane morphology and rod organization in flexible vesicles AI翻译
  作者：van der Ham, Stijn; Matias, Andre F. V.; Dijkstra, Marjolein; Vutukuri, Hanumantha Rao
  作者单位：University of Twente; Utrecht University
  摘要：The ordering of rod-like particles in soft, deformable containers emerges from the interplay of anisotropic interactions, geometric confinement, and boundary compliance. This competition couples internal particle organization to container morphology, producing behavior distinct from both rigid confinement and bulk systems. Such coupling is also relevant to biological contexts in which filamentous structures are confined by deformable membranes. Using a minimal model combining experiments and s...
• Detecting changepoints in dynamical systems: Modeling time-varying transmission of seasonal influenza AI翻译
  作者：Oza, Ajay N.; O'Brien, Katie M.; Gleeson, James P.
  作者单位：University of Limerick
  摘要：Seasonal influenza epidemics exhibit complex transmission dynamics influenced by time-varying extrinsic factors such as social behavior and seasonal effects. Estimating changes in transmission rates is critical to enable accurate forecasting of the epidemic curve. This study presents a framework for detecting changepoints in the transmission parameter ( beta t ), applied as a piecewise constant function within a deterministic compartmental model. Using hospitalized case data from four recent i...
• A redox- and proton-coupled inner membrane transporter mediates copper import to the bacterial cytoplasm AI翻译
  作者：Palmer, Caitlin D.; Gamage, Madujika A. Horadigala; Ho, Madeline B.; Liyana Withanage, Nadeesha T.; Hadley, Rose C.; Hoffman, Brian M.; Meloni, Gabriele; Rosenzweig, Amy C.
  作者单位：Northwestern University; University of Texas System; University of Texas Dallas; Northwestern University
  摘要：Copper homeostasis in bacteria requires tightly regulated import systems to balance copper's essential redox functions with its inherent cytotoxicity; yet, the mechanisms of cytoplasmic copper uptake remain poorly understood. In particular, the widespread CopD family of transmembrane proteins has been linked genetically to cytoplasmic copper import, but has not been mechanistically characterized. Here, using in vivo uptake assays, proteoliposome-based, real-time copper translocation kinetic me...
• A BCG hydrogel enables localized NOD2/STING activation to overcome resistance to immune checkpoint blockade AI翻译
  作者：Xiao, Ziyuan; Xu, Huizhen; Ma, Ningyi; Lei, Lei; Cong, Chunyu; Sun, Ningyi; Wang, Guodong; Chen, Xingmei; Ren, Ke; Qiao, Haishi
  作者单位：China Pharmaceutical University; Chengdu Medical College; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Resistance to immune checkpoint blockade (ICB) often arises from immunologically cold tumors enriched in suppressive myeloid cells. Previous studies have implicated NOD2 signaling in antitumor immunity and in modulation of ICB responses, but approaches to engage this pathway effectively and durably within tumors remain limited. Here, single-cell transcriptomic analysis of colorectal cancer identified a NOD2 high tumor-associated macrophage (TAM) subset enriched for inflammatory and immune-acti...
• Light-controlled disruption of cancer cell dormancy via photoswitchable stress hormone receptor degraders AI翻译
  作者：Freitag, Karina M.; Scheuplein, Robin; Orlacchio, Chiara; Ansuinelli, Viola; Fava, Tommaso; Fischer, Vincent; Zhang, Bohan; Kretschmer, Miriam; Gazorpak, Mahshid; Carreira, Erick M.; Gapp, Katharina
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich
  摘要：Cancer cell dormancy is a key contributor to therapy resistance and disease relapse. The glucocorticoid receptor (GR), a major mediator of stress hormone signaling, has emerged as a central regulator of dormancy in non-lymphoid solid tumors, particularly lung cancer. However, systemic GR inhibition or degradation using conventional Proteolysis Targeting Chimeras (PROTACs) risks widespread on-target toxicity due to their constitutive activity. We hypothesized that integrating photoswitchable el...
• Large language models pass a standard three-party Turing test AI翻译
  作者：Jones, Cameron R.; Bergen, Benjamin K.
  作者单位：University of California System; University of California San Diego; State University of New York (SUNY) System; Stony Brook University
  摘要：The Turing test has been widely discussed as a test of machine intelligence, but it also provides a measure of how humans distinguish other humans from machines. We evaluated 4 systems (ELIZA, GPT-4o, LLaMa-3.1-405B, and GPT-4.5) in two randomized, controlled, and preregistered Turing tests on independent populations. Participants had 5 min conversations simultaneously with another human participant and one of these systems before judging which conversational partner they thought was human. Wh...
• Molecular de-extinction looks to the past to find the molecules of the future AI翻译
  作者：Adam, David
• Extreme nonequilibrium synthesis of a Ca-Cu-Si clathrate during the Trinity nuclear test AI翻译
  作者：Bindi, Luca; Mihalkovic, Marek; Widom, Michael; Steinhardt, Paul J.
  作者单位：University of Florence; Slovak Academy of Sciences; Institute of Physics, SAS; Carnegie Mellon University; Princeton University
  摘要：The Trinity nuclear test of July 16, 1945, generated extreme transient conditions that produced trinitite, a silicate glass containing rare metallic phases. Here we report the discovery and structural and chemical characterization of a previously unknown Ca-Cu-Si type-I clathrate, (Ca3.3Cu0.4Fe0.3)(Sigma=4)Si-23, identified within a Cu-rich metallic droplet embedded in red trinitite. Single-crystal X-ray diffraction shows that this phase adopts the cubic clathrate-I topology, representing the ...
• Evolution of genome-wide barriers to gene flow during complex speciation in rattlesnakes AI翻译
  作者：Farleigh, Keaka; Highland, Dylan K.; Alderman, Megan G.; Francioli, Yannick; Hirst, Samuel R.; Faber, Ellie M.; Perry, Blair W.; Holding, Matthew L.; Castaneda-Gaytan, Gamaliel; Borja, Miguel; Franz-Chavez, Hector; Parkinson, Christopher L.; Strickland, Jason L.; Margres, Mark J.; Mackessy, Stephen P.; Meik, Jesse M.; Castoe, Todd A.; Schield, Drew R.
  作者单位：University of Virginia; University of Texas System; University of Texas Arlington; State University System of Florida; University of South Florida; Michigan State University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Universidad Juarez del Estado de Durango; Clemson University; University of South Alabama; University of Northern Colorado; Texas A&M University System; Tarleton State University
  摘要：Speciation with gene flow poses a central paradox: how do genome-wide barriers to gene exchange accumulate as recombination continually breaks down associations among selected loci? Although theory predicts that together recombination, selection, and genome structure shape reproductive isolation, empirical studies often report conflicting patterns, suggesting that these determinants change across the speciation continuum. Here we compare genomic landscapes of introgression across rattlesnake l...