21期

最新文章

• Extremism does not stop at borders, and neither should our models AI翻译
  作者：Sharafi Zadegan, Milad; Gruda, Dritjon; Jonason, Peter K.
  作者单位：Universidade Catolica Portuguesa
• Apoptosis-inducing factor starts its activity within mitochondria revealed by in situ vibrational probes AI翻译
  作者：Zhu, Jinyu; Liao, Yi; Feng, Mengfan; Song, Li; Li, Wei; Cai, Linjun; Han, Xiao Xia
  作者单位：Jilin University; Jilin University
  摘要：Apoptosis-inducing factor (AIF) is a flavoprotein located in the mitochondrial intermembrane space, and it is believed to trigger caspase-independent cell death after its release from the mitochondria into the nucleus. Here, the proapoptotic activity of AIF within mitochondria and the underlying molecular mechanism are explored using label-free vibrational spectroscopy and imaging. Electron transfer between AIF and cytochrome c (Cyt c) is evidenced by resonance Raman spectroscopy, and the deta...
• IglF mediates type VI secretion system spike assembly and promotes Francisella virulence AI翻译
  作者：Degabriel, Manon; Guiot, Esteban; Marcotte, Melissa; Berthollier, Coline; Soussan, Diane; Bataille, Laure; Journeau, Clemence; Ducret, Adrien; Dayet, Sarah; Mosnier, Amandine; Martin, Amandine; Gueguen-Chaignon, Virginie; Boisset, Sandrine; Fronzes, Remi; Terradot, Laurent; Henry, Thomas
  作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); Universite Lyon 1; CNRS - National Institute for Biology (INSB); Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Grenoble Alpes; CEA; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; CNRS - National Institute for Biology (INSB); Universite Grenoble Alpes (UGA)
  摘要：Type VI secretion systems (T6SSs) are widely distributed among Gram-negative bacteria, where they mostly act to promote bacterial warfare. Bacteria from the Francisella genus possess T6SSs that phylogenetically diverge from all other T6SSs and constitute the T6SSii subtype. Francisella tularensis, the agent of tularemia, relies on its T6SS to secrete effectors into host cells. Despite the key role of this nanomachine in Francisella virulence, the structure of T6SSii and the mechanism underlyin...
• Reply to Guido et al.: The importance of credibility in outreach interventions AI翻译
  作者：Linos, Elizabeth; Lasky-Fink, Jessica
  作者单位：Harvard University
• Bleb expansion requires transient membrane invaginations that sequester curvature-preferring proteins AI翻译
  作者：Maekawa, Yuki; Yoshii, Saori R.; Mizushima, Noboru; Ikenouchi, Junichi
  作者单位：Kyushu University; University of Tokyo; University of Tokyo
  摘要：Bleb-based cell migration involves rapid plasma membrane expansion driven by intracellular pressure. How the membrane reorganizes its curvature and protein composition during this process remains unclear. Here, we identify a distinct inward membrane structure, termed the sub-bleb invagination (SBI), that forms de novo at the bleb base during expansion. SBIs display strong positive curvature and transiently sequester curvature-preferring integral membrane proteins such as Caveolin-1 and Piezo1 ...
• Hydraulic geometry hypothesis allows reverse engineering of 3D quasi-equilibrium landscapes from 2D channel networks: Earth, Mars, Titan AI翻译
  作者：Zhang, Li; Borse, Dnyanesh; Singh, Arvind; Pizzuto, James E.; Fu, Xudong; Parker, Gary
  作者单位：North China Electric Power University; State University System of Florida; University of Central Florida; University of Delaware; Tsinghua University; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：The 2D dendritic structure of stream networks within fluvial catchments has not previously been linked to reach-scale channel processes. Existing extensions of 2D network models to 3D landscapes yield only pixelized landscapes, without resolving channels or their properties. At-a-point relations for hydraulic geometry alone provide no insight into how fluvial processes sculpt 3D landscapes in which channels are embedded. We provide this insight by reverse-engineering generic fluvial landscapes...
• Spectral mapping reveals a resemblance of the anesthetic brain state to both sleep and coma AI翻译
  作者：Helfrich, Janna D.; Szaflarski, Jerzy; Naevra, Marianne C. J.; Romunstad, Luis; Walker, Matthew P.; Mander, Bryce A.; Knight, Robert T.; Larsson, Pal G.; Helfrich, Randolph F.
  作者单位：Yale University; Yale University; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Oslo; University of Oslo; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Irvine; Yale University; Yale University; Yale University
  摘要：General anesthesia is often compared to sleep but may more closely resemble a medically induced coma. While all three states involve a loss of awareness, the extent of their neural similarity remains unclear. Electrophysiological markers, such as delta activity (< 4 Hz), are present in slow wave sleep, disorders of consciousness (DoC, including coma), and propofol anesthesia but are absent during rapid eye movement (REM) sleep. Frontal alpha oscillations are a key feature of propofol anesthesi...
• Combined generalist and host-specific transcriptional strategies enable host generalism in the fungal pathogen Botrytis cinerea AI翻译
  作者：Singh, Ritu; Muhich, Anna Jo; Tom, Cloe; McMillan, Jack; Srinivas, Karishma; Faieta, Lucca; Caseys, Celine; Kliebenstein, Daniel J.
  作者单位：University of California System; University of California Davis
  摘要：How generalist pathogens infect phylogenetically diverse hosts remains a central question in plant-pathogen biology. In particular, the extent to which broad host range is enabled by genetic variation vs. transcriptional plasticity is unclear. To investigate how variation and plasticity contribute to generalism, we studied the generalist necrotrophic fungus Botrytis cinerea that infects more than 1,500 plant species. Using a cross-infection matrix of 72 B. cinerea isolates infecting 57 plant g...
• Emergence of cooperation due to opponent-specific responses in Prisoner's Dilemma AI翻译
  作者：Morozov, Alexandre V.; Feigel, Alexander
  作者单位：Rutgers University System; Rutgers University New Brunswick; Hebrew University of Jerusalem
  摘要：Complex life would be impossible without cooperation at all levels of biological organization. However, Darwinian selection is commonly believed to favor selfish behavior, making societies of cooperators vulnerable to cheaters. A quintessential model of this behavior is the game of Prisoner's Dilemma in which cheaters always win, even though being cooperative results in greater rewards. Numerous scenarios have been proposed that allow for the evolution of cooperation in restrictive settings th...
• Position-dependent feedback drives scaling and robustness of morphogen gradients AI翻译
  作者：Mosby, Lewis Scott; Hadjivasiliou, Zena
  作者单位：Francis Crick Institute; University of London; University College London; University of London; University College London
  摘要：Developmental patterning is remarkably robust to intrinsic and extrinsic variation. Morphogen gradients are a key mechanism driving patterning, and themselves often scale with the size of developing tissues and exhibit robustness to other perturbations. Recent data indicate that expander molecules, thought to drive morphogen scaling through expansion-repression (ER) feedback, have concentration profiles that are position dependent. This challenges the currently accepted ER mechanism that requi...