21期

最新文章

• Attention problems and cortical maturation in a large longitudinal sample of youths: The importance of accounting for sex differences AI翻译
  作者：O'Connor, Shannon D.; Loughnan, Robert; Ahern, Jonathan; Fan, Chun Chieh; Althoff, Robert R.; Garavan, Hugh; Potter, Alexandra; Albaugh, Matthew D.
  作者单位：University of Vermont; Laureate Institute for Brain Research, Inc.; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Delayed age-related cortical thinning has been proposed as a biomarker of attention-related psychopathology and attention-deficit/hyperactivity disorder (ADHD), but these findings have not been adequately replicated in large, longitudinal samples with sufficient power to account for potential confounds such as co-occurring psychopathology and sex differences in neurodevelopment. Here, we examined whether previously reported associations between attention problems and delayed cortical thickness...
• Plant Kelch phosphatases are Ser/Thr phosphatases involved in cell cycle regulation AI翻译
  作者：Rico-Resendiz, Felix; Pri-Tal, Oded; Raia, Pierre; Moretti, Andrea; Chen, Houming; Yu, Jun; Broger, Larissa; Fuchs, Christelle; Hothorn, Ludwig A.; Loubery, Sylvain; Hothorn, Michael
  作者单位：University of Geneva; University of Geneva; University of Geneva; Leibniz University Hannover; CSL
  摘要：Brassinosteroids (BRs) are plant steroid hormones sensed by the membrane receptor kinase BRI1. Activation of BRI1 leads to the dephosphorylation of BZR1/BES1 transcription factors. Overexpression of the Kelch phosphatase BRI1 SUPPRESSOR 1 (BSU1) rescued the growth defects of bri1 mutants. Subsequent studies identified BSU1 as a protein tyrosine phosphatase, which promotes BR signaling by dephosphorylating a phosphotyrosine in the glycogen synthase kinase 3 BIN2. Crystal structures of the BSU1 ...
• Maynard Smith's analogy, realized: Common ancestry constrains evolutionary percolation through protein space AI翻译
  作者：Manivannan, Swathi Nachiar; Ogbunugafor, C. Brandon
  作者单位：Yale University; The Santa Fe Institute
• Systematic determination of disulfide bond reduction potentials reveals a nonequilibrium redox hierarchy in cyanobacteria AI翻译
  作者：Tanaka, Kenya; Kondo, Akihiko; Hasunuma, Tomohisa
  作者单位：Kobe University; Kobe University; University of Osaka; RIKEN; Kobe University
  摘要：Disulfide bonds act as reversible switches that regulate cellular function in nearly all organisms. Their behavior is set by the midpoint potential (E m), yet E m is known for only a small number of sites, mostly in purified proteins studied away from their natural partners. We developed a mass-spectrometry workflow that measures E m directly from native cell lysates. By equilibrating proteins of the cyanobacterium Synechocystis sp. PCC 6803 in defined redox buffers and reading out the oxidati...
• Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs AI翻译
  作者：Hughes, Ivy K.; Kharytonchyk, Siarhei; Ramaswamy, Sita; Jalloh, Sallieu; Hood, James B.; He, Xianbao; Henderson, Andrew J.; Akiyama, Hisashi; Telesnitsky, Alice; Gummuluru, Suryaram
  作者单位：Boston University; University of Michigan System; University of Michigan; Boston Medical Center
  摘要：Heterogenous transcription start site (TSS) usage dictates the 5 ' leader structure and function of unspliced HIV-1 RNAs (usRNA). We and others have previously reported that expression and Rev/CRM1-mediated nuclear export of HIV-1 usRNA in macrophages activates MDA5, MAVS, and innate immune signaling cascades. In this study, we reveal that MDA5 sensing of viral usRNA is largely determined by TSS and cytoplasmic RNA function in macrophages. We show that HIV-1 usRNAs (cap1G) that are preferentia...
• Early adjunct anti-PD-L1 immunotherapy improves outcomes and restores infection-induced immune paralysis in mice with invasive pulmonary mucormycosis AI翻译
  作者：Wurster, Sebastian; Pantaleon Garcia, Jezreel; Wang, Yongxing; Albert, Nathaniel D.; Bharadwaj, Uddalak; Matula, Lauren; Lewis, Russell E.; Evans, Scott E.; Kontoyiannis, Dimitrios P.
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Padua
  摘要：Invasive pulmonary mucormycosis (IPM) is a severe opportunistic mold infection whose outcome is predominantly host driven. Preclinical proof-of-concept studies and clinical case reports in salvage therapy settings suggested a benefit of immune checkpoint inhibitors (ICIs) in IPM management. However, the kinetics of infection-induced immune paralysis and optimal timing of ICI therapy remain poorly understood. Here, we performed sequential nCounter-based transcriptomics on lung tissue of cycloph...
• Spatially tunable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues AI翻译
  作者：Battistoni, Giorgia; Torres-Garcia, Sito; Sia, Chee Ying; Corriero, Silvia; Boquetale, Carla; Williams, Elena; Cregeen, Anna; Wasilewska, Karolina; Alini, Martina; Hemmer, Nicole; Balasubramanian, Shankar; Nicholson, Benjamin Czech; Hannon, Gregory J.; Bressan, Dario
  作者单位：MRC Laboratory Molecular Biology; University of Cambridge; CRUK Cambridge Institute; Cancer Research UK; University of Cambridge
  摘要：Mapping the molecular identities and functions of cells within their spatial context is key to understanding the complex interplay within and between tissue neighborhoods. A wide range of methods have recently enabled spatial profiling of cellular anatomical contexts, some offering single-cell resolution. These use different barcoding schemes to encode either the location or the identity of target molecules. However, all these technologies face a trade-off between spatial resolution, depth of ...
• Efficient quantum algorithm for dissipative nonlinear differential equations (vol. 118, e2026805118, 2021) AI翻译
  作者：Liu, Jin-Peng; Kolden, Herman Oie; Krovi, Hari K.; Loureiro, Nuno F.; Trivisa, Konstantina; Childs, Andrew M.
• Climate mediates phenological and phylogenetic differentiation in plant invasions AI翻译
  作者：Ramirez-Parada, Tadeo H.; Park, Isaac W.; Peng, Shijia; Nishino, Misako; Kartesz, John T.; Record, Sydne; Davis, Charles C.; Mazer, Susan J.
  作者单位：University of California System; University of California Santa Barbara; Harvard University; University System of Georgia; Georgia Southern University; University of Oxford; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono
  摘要：Darwin's Naturalization Conundrum holds that both functional similarity and distinctiveness can facilitate biological invasions: invaders similar to natives may succeed through preadaptation to local abiotic conditions, whereas functionally distinct invaders may succeed by reducing competition. Yet the contexts in which either mechanism dominates are unclear. Prior research has primarily attributed variability in native-invasive differentiation to shifts in the balance between biotic and clima...
• Decisional reference point pathology: A cognitive mechanism for and a correlate of major depressive disorder in humans AI翻译
  作者：Vittala, Aadith; Wu, Lulu; Yan, Dongni; Liebers, David; Tell, Elizabeth; Song, Xiaotong; Dashti, Damon; Louie, Kenway; Raio, Candace; Iosifescu, Dan V.; Glimcher, Paul W.
  作者单位：New York University; New York University; Nathan Kline Institute for Psychiatric Research; University of Zurich
  摘要：The decisional reference point, the central mechanism underlying behavioral economics, conditions our evaluations of all reinforcers. Whether a given event is experienced as positive or negative depends on this reference point. A pathological elevation of the reference point would lead a person to experience once pleasurable activities as negative reinforcers. Thus, it has been hypothesized that a reference point pathology may play a critical role in the symptomology of major depressive disord...