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作者：Kay, Raphael; Cocks, Ross J.; Katrycz, Charles; Jakubiec, J. Alstan; Wilborn, Atalaya Milan; Omair, Rafiq; Aizenberg, Joanna; Hatton, Benjamin D.
作者单位：University of Toronto; University of Toronto; Harvard University; University of Toronto; University of Toronto; Harvard University
摘要：Branching patterns can emerge when one fluid is injected into a more viscous one within a quasi-two-dimensional cavity. While these patterns have dazzled physicists for decades, modern engineering efforts have focused on suppressing, rather than leveraging, these flow instabilities. Here, by designing fluidic devices with calibrated geometries, liquid absorptivities, and rheology, we exploit the thermal sensitivity of the Saffman-Taylor instability to achieve thermoregulatory shading systems w...
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作者：Lim, Jongwon; Van, An Bao; Wester, Matthew; Koprowski, Katherine; Valera, Enrique; Bashir, Rashid
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Autocatalytic CRISPR architecture offers amplification-free nucleic acid detection by directly linking target recognition to self-reinforcing ribonucleoprotein (RNP) generation. However, spontaneous background activation remains a key barrier, because strand invasion or unwinding events can initiate unintended amplification and diminish assay specificity. Here, we introduce a dual-blocking CRISPR-Cascade design that independently cages both the guide RNA and trigger DNA, establishing an intrin...
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作者：Pourmotabbed, Haatef; Chang, Catie
作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University
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作者：Aslim, Erkmen G.; Currie, Janet; Herbst, Chris M.; Tekin, Erdal
作者单位：University of Vermont; Yale University; Leibniz Association; Ifo Institut; National Bureau of Economic Research; Arizona State University; Arizona State University-Downtown Phoenix; American University
摘要：Immigrants play a critical role in the US childcare workforce, yet little is known about how immigration enforcement shapes employment in this essential sector. We study how the sharp escalation in community-based Immigration and Customs Enforcement (ICE) activity following President Trump's inauguration in early 2025 affected childcare employment in the United States. Monthly data from the Current Population Survey are linked to compiled state-level ICE arrest records from September 2023 thro...
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作者：Geng, Xiaorui; Liu, Silan; Pan, Yuanwei; Ge, Yun; Rao, Lang
作者单位：Shenzhen Bay Laboratory; Shenzhen Medical Academy of Research & Translation (SMART); Westlake University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen)
摘要：The tumor glycocalyx forms a protective shield that masks checkpoint proteins and compromises the efficacy of immunotherapies. While the bacterial protease StcE can degrade this barrier by cleaving O-glycosylated mucin domains, its therapeutic potential is hindered by off-target toxicity and high immunogenicity. To overcome these limitations, we developed a biomimetic platform of cell membrane fusion nanovesicles (FNVs) that codisplay StcE and CD47 nanobodies (nCD47) for spatially controlled g...
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作者：Guzman, Marcelo; Ciarella, Simone; Liu, Andrea J.
作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Universite Paris Cite; Ecole Normale Superieure (ENS); Sorbonne Universite; University of Pennsylvania; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); The Santa Fe Institute
摘要：Autonomous physical learning systems modify their internal parameters and solve computational tasks without relying on external computation. Compared to traditional computers, they enjoy distributed and energy-efficient learning due to their physical dynamics. In this paper, we introduce a self-learning resistor network, the Restricted Kirchhoff Machine, capable of solving unsupervised learning tasks akin to the Restricted Boltzmann Machine algorithm. The circuit relies on existing technology ...
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作者：Pritisanac, Iva; Alderson, T. Reid; Kolaric, Desika; Zarin, Taraneh; Xie, Shuting; Lu, Alex; Alam, Aqsa; Maqsood, Abdullah; Youn, Ji-Young; Forman-Kay, Julie D.; Moses, Alan M.
作者单位：University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); Medical University of Graz; Technical University of Munich; University of Toronto; University of Toronto; University of Toronto
摘要：Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome and defy the established structure-function paradigm. Because IDRs often have limited positional sequence conservation, the functional classification of IDRs using standard bioinformatics is generally not possible. Here, we show that evolutionarily conserved molecular features of IDRs enable clustering of the human disordered proteome (IDRome) into a map with strong functional enrichments. We quantify ho...
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作者：Corell-Escuin, Paula; Belmonte-Ballester, Sonia; Adhav, Anmol; Marina, Alberto; Gadea-Salom, Laura; Martinez-Gil, Luis; Aledavood, Elnaz; Fernandez-Escamilla, Ana Maria; Saez, Ana Gomez; Gougeard, Nadine; Dee, Kieran; Murcia, Pablo R.; Magos, Eliza Adriana; Llena, Carmen; Peris-Martinez, Cristina; D'Auria, Giuseppe; Artacho, Alejandro; Mengual-Chulia, Beatriz; Lopez-Labrador, F. Xavier; Mira, Alex; Ferrer, Maria Desamparados
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作者：Ning, Weixuan; Arick, Mark A.; Udall, Joshua A.; Hsu, Chuan-Yu; Abdala-Roberts, Luis; Solis-Rodriguez, Uriel; Briones-May, Yeyson; Magbanua, Zenaida V.; Pechanova, Olga; Bustos-Segura, Carlos; Clancy, Mary V.; Diaz-Cruz, Sandra; Garnica-Cabrera, Alejandra; Mamin, Marine; Yu, John Z.; Turlings, Ted C. J.; Hu, Guanjing; Peterson, Daniel G.; Grover, Corrinne E.; Wendel, Jonathan F.
作者单位：Iowa State University; Mississippi State University; United States Department of Agriculture (USDA); USDA Agricultural Research Service; Universidad Nacional Autonoma de Mexico; Universidad Autonoma de Yucatan; Mississippi State University; University of Neuchatel; Henan University; Henan University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Chinese Academy of Agricultural Sciences; Institute of Cotton Research, CAAS
摘要：Gossypium hirsutum is the leading fiber crop globally, but its origin as a domesticated plant and patterns of diversity in the wild remain to be elucidated. Here, we use extensive sampling of wild populations and comparative genome sequence data to illuminate the scope and patterning of wild cotton diversity across its native range. Analyses confirm the hypothesis that the Yucat & aacute;n Peninsula (M & eacute;xico) is the center of domestication, from which the original perennial forms and l...
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作者：Noor, Elad; Jefimov, Kirill; Bifulco, Ersilia; Onischenko, Evgeny
作者单位：Weizmann Institute of Science; University of Bergen
摘要：Cells continuously produce and degrade molecules, essential for maintaining homeostasis. The study of these dynamics has gained momentum since the development of pulse-chase methods, utilizing fluorescent or isotopic labeling to assess properties such as turnover rates or half-lives. However, standard analyses of these experiments often depend on assumptions such as the homogeneity of analyzed molecules or their immediate labeling, which do not always hold. Here, we show that the readouts of s...
