29期

最新文章

• Chromatin end-anchored chromosome-sized domains and promoter loops organize a transcriptionally active genome in Tetrahymena AI翻译
  作者：Hu, Tengfei; Song, Xiaoyuan; Luo, Zhengyu
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Three-dimensional (3D) genome architecture shapes gene regulation, yet the folding principles of compact unicellular genomes remain unclear. Among unicellular eukaryotes, the ciliate Tetrahymena thermophila provides a distinctive model, harboring a transcriptionally active somatic macronucleus (MAC) with a genome fragmented into gene-dense minichromosomes and a silent, intact germline micronucleus. To delineate macronuclear chromatin organization, we integrated nucleosome-resolution Micro-C, A...
• HDA19-mediated deacetylation of histone H3.3 at lysines 27 and 36 regulates plant sensitivity to salt stress AI翻译
  作者：Kotnik, Florian; Ueda, Minoru; Ito, Akihiro; Ishida, Junko; Takahashi, Satoshi; Sakai, Katsuyuki; Takagi, Hiroshi; Seidel, Julian; Abe, Takahiro; Eirich, Jurgen; Takahashi, Shunji; Schwarzer, Dirk; Seki, Motoaki; Finkemeier, Iris
  作者单位：University of Munster; RIKEN; Tokyo University of Pharmacy & Life Sciences; RIKEN; RIKEN; Eberhard Karls University of Tubingen; Yokohama City University; Saitama University
  摘要：Plants survive extreme environments through rapid chromatin reprogramming, yet the epigenetic marks that confer stress resilience remain poorly understood. Histone deacetylase HDA19 is a key epigenetic regulator in Arabidopsis, and hda19-deficient mutants display tolerance to multiple abiotic stresses, including drought, heat, and salinity. Using lysine acetylome profiling, we identified a noncanonical K27/K36 diacetylation mark on histone H3.3, among nine H3 variants, as a specific substrate ...
• Evolvable AI needs operational risk thresholds AI翻译
  作者：Rana, Shweta; Singh, Harpreet
  作者单位：Academy of Scientific & Innovative Research (AcSIR)
• Experimental drought drives divergent succession of soil microbiota AI翻译
  作者：Deng, Sihang; Yang, Yunfeng; Guo, Xue; Yuan, Mengting Maggie; Zhang, Ya; Wu, Linwei; Shi, Weiling; Zhou, Xishu; Cornell, Carolyn R.; Bates, Colin T.; Liu, Xiaojun A.; Zhang, Qiuting; Tian, Renmao; Jian, Siyang; Liu, Suo; Liang, Zhengxiong; Lei, Jiesi; Gao, Qun; Shi, Zheng; Wu, Liyou; Liu, Xueduan; Luo, Yiqi; Ning, Daliang; Tiedje, James M.; Zhou, Jizhong
  作者单位：Tsinghua University; Tsinghua University; Tsinghua Shenzhen International Graduate School; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Research Center for Eco-Environmental Sciences (RCEES), CAS; University of Oklahoma System; University of Oklahoma - Norman; University of California System; University of California Berkeley; Peking University; Peking University; Central South University; Rice University; Cornell University; Michigan State University; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma - Norman; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：As droughts become increasingly severe and prolonged worldwide, understanding how belowground biodiversity changes over time under water limitation is critical for assessing ecosystem resilience. However, long-term and continuous observations of soil microbial responses to drought remain rare. Here, using a 6-y experimental drought in a tallgrass prairie ecosystem, we showed that experimental drought reshaped the community compositions of soil bacteria, fungi, and protists, accompanied by prog...
• Age-associated epigenetic drift trajectory and cross-national disparities in accelerated aging in domestic dogs AI翻译
  作者：Jang, Subin; Kim, Seong Jun; Kang, Dayeon; Hong, Chae-yeon; Bok, Eun-yeong; Lee, Sung-Lim; Choe, Yong-Ho; Kim, Jaemin
  作者单位：Gyeongsang National University; Gyeongsang National University; Gyeongsang National University; Gyeongsang National University; National Institute of Animal Science, Republic of Korea; Rural Development Administration (RDA), Republic of Korea; Gyeongsang National University
  摘要：Aging is accompanied by both increasing interindividual heterogeneity and systematic, age-associated alterations in DNA methylation (DNAm). Here, we investigated these complementary dimensions of epigenetic aging in dogs using global and locus-specific measures of epigenetic drift alongside clock-based estimates of biological aging. We observed pervasive, yet genomically structured epigenetic instability throughout the canine lifespan. The extent of age-associated epigenetic drift further vari...
• A general mobility analysis framework to reveal nonintuitive kinematic characteristics of rigid origami AI翻译
  作者：Li, Jihui; Zhu, Jinye; Qu, Shaoxing
  作者单位：Zhejiang University
  摘要：Rigid origami exhibits intriguing reconfigurability governed by geometric constraints imposed by its creases. This intrinsic relationship gives rise to nonintuitive kinematic characteristics, including the number of degrees of freedom (DOFs) and their corresponding motion paths in complex configurations. Here, we develop a general mobility analysis framework to reveal the indeterminate kinematic characteristics of rigid origami. By first analytically deriving kinematic compatibility conditions...
• IVT-free, chemically synthesized protein-encoding RNA oligonucleotides for rapid production of personalized cancer vaccines AI翻译
  作者：Pan, Qian; Zhang, Chi; Wang, Xinyue; Yin, Jie; She, Shengnan; Chen, Xi; Dong, Ruitao; Wu, Ying; Liao, Xinyuan; Wang, Yanyan; Yan, Hui; Kou, Haomeng; Wang, Wanjia; Cao, Yong; Yang, Hui; Qu, Liang
  作者单位：Fudan University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Fudan University; Fudan University
  摘要：Personalized mRNA neoantigen vaccines demonstrate great potential in cancer therapy, but their customization typically requires more than three months, risking the loss of the optimal therapeutic window for patients. This delay is primarily due to the reliance of current mRNA vaccine production on plasmid fermentation and in vitro transcription (IVT), which involve multiple complex steps. Chemically synthesized RNA oligonucleotides, such as antisense oligonucleotides (ASOs), are produced spari...
• Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells AI翻译
  作者：Raghuvanshi, Shilpa; Sharma, Pawan; Singh, Sarman; Van Kaer, Luc; Das, Gobardhan
• Technical sophistication is not evidence AI翻译
  作者：Sun, T. Anthony
  作者单位：University of Helsinki; University of Helsinki
• Many AI analysts, one dataset: Navigating the agentic data science multiverse AI翻译
  作者：Bertran, Martin; Fogliato, Riccardo; Wu, Zhiwei Steven
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Amazon.com; University of Pittsburgh; Carnegie Mellon University
  摘要：Empirical conclusions depend not only on data but also on analytic decisions. Many-analyst studies have quantified this dependence: independent teams testing the same hypothesis on the same dataset regularly reach conflicting conclusions. But such studies require costly human coordination. We show that fully autonomous AI analysts built on large language models (LLMs) can, cheaply and at scale, produce the analytic dispersion observed in human many-analyst studies. In our framework, each AI an...