29期

最新文章

• Dielectric levitation optical tweezers for powerful mesoscale biomanipulation AI翻译
  作者：Liu, Haobing; Fu, Rongxin; Nan, Fan; Guo, Zongliang; Zhao, Menglei; Zhang, Yifan; Guo, Shutong; Li, Hang; Chen, Kangfu; Chu, Bing; Lou, Kai; Zhang, H. P.; Xie, Huikai; Yang, Zhugen; Li, Jiafang; Cooper, Jonathan M.; Zhang, Shuailong
  作者单位：Beijing Institute of Technology; Beijing Institute of Technology; Beijing Institute of Technology; Beijing Institute of Technology; Helmholtz Association; Karlsruhe Institute of Technology; Beijing Institute of Technology; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Chemistry, CAS; Shanghai Jiao Tong University; Cranfield University; Beijing Institute of Technology; University of Glasgow
  摘要：Optical tweezers (OT), a cornerstone of micromanipulation, are fundamentally constrained by substrate-induced adhesion and friction, limiting their application to mesoscale objects and fragile biological specimens where overcoming these resistive forces requires physiologically damaging laser powers. Here, we overcome this long-standing challenge by introducing dielectric levitation optical tweezers (DL-OT), a multiphysics platform that seamlessly integrates alternating-current dielectric levi...
• Parametrically amplified Josephson plasma waves in YBa2Cu3O6+x: Evidence for local superconducting fluctuations up to the pseudogap temperature T∗ AI翻译
  作者：Michael, Marios H.; Demler, Eugene; Lee, Patrick A.
  作者单位：Max Planck Society; Swiss Federal Institutes of Technology Domain; ETH Zurich; Massachusetts Institute of Technology (MIT)
  摘要：Experiments that subject underdoped YBa2Cu3O6+x (YBCO) to intense terahertz pulses at temperatures between the transition temperature T-c, and the pseudogap scale T* have revealed a reflectivity edge that resembles that of the superconducting state, together with second harmonic generation of a probe pulse modulated at a similar frequency. These have been interpreted in terms of parametric amplification of the lower Josephson plasmon mode. Since this mode is often associated with coherent osci...
• Plants are a powerful proxy for global tidal marsh methane fluxes AI翻译
  作者：Wilson, Emily M.; Balint, Sawyer J.; Fulweiler, Robinson W.
  作者单位：Boston University; Boston University
  摘要：Methane (CH4) emissions can reduce the climate benefits of tidal marshes. Yet the drivers of tidal marsh CH4 emissions remain poorly quantified, and salinity, the most well-established proxy for tidal marsh CH4 fluxes, has low predictive performance. Here, we demonstrate that plant species out performs salinity as a single predictor of global tidal marsh CH4 fluxes, providing a powerful and simple predictor on its own. A multiproxy approach combining plant species with other predictors (i.e., ...
• The LV map leads to misleading interpretations of coexistence AI翻译
  作者：Ernst, Isabell C.; Spaak, Jurg W.
  作者单位：RPTU University Kaiserslautern
• Combined signals of scientific and social consensus best mobilize action on societal challenges even if government and industry oppose AI翻译
  作者：Sabherwal, Anandita Chakraborty; Sparkman, Gregg
  作者单位：Boston College; Princeton University; Princeton University
  摘要：When facing real-world societal challenges, people make decisions about how to act based on multiple, often conflicting messages from various influential stakeholders such as governments, scientists, fellow citizens, and private companies. How does the public decide to act amid potentially converging or diverging signals from multiple entities in society? Which entities remain influential even if other groups appear apathetic or stand in opposition? This question becomes especially important i...
• Quantitative calibration of a spatial QSP model identifies fibroblast impact on HCC immunotherapy AI翻译
  作者：Zhang, Shuming; Wang, Hanwen; Cho, Yeonju; Rocha, Heber L.; Wong, Wendy; Yarchoan, Mark; Jaffee, Elizabeth M.; Ho, Won Jin; Kagohara, Luciane T.; Fertig, Elana J.; Popel, Aleksander S.; Deshpande, Atul
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Indiana University System; Indiana University Bloomington; Johns Hopkins University; Johns Hopkins Medicine; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; Johns Hopkins University; Johns Hopkins University
  摘要：Computational models are increasingly used to predict treatment response and optimize cancer therapeutic strategies. Quantitative systems pharmacology (QSP) models mechanistically simulate tumor progression and pharmacological interventions, enabling virtual clinical trials, model-informed drug development, and biomarker discovery, but they lack spatial resolution to represent tumor microenvironment (TME) architecture. Coupling QSP with agent-based modeling creates spatial QSP (spQSP) framewor...
• Evidence of intertwined pair density and charge density wave orders in UTe2 AI翻译
  作者：Zhu, Zhen; Huang, Yudi; May-Mann, Julian; Liu, Kaiming; Wu, Zheyu; Saha, Shanta R.; Paglione, Johnpierre; Eaton, Alexander G.; Cabala, Andrej; Valiska, Michal; Fradkin, Eduardo; Madhavan, Vidya
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Stanford University; University of Cambridge; University System of Maryland; University of Maryland College Park; Canadian Institute for Advanced Research (CIFAR); Charles University Prague; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：The strongly correlated spin-triplet superconductor UTe2 hosts an unusual magnetic-field-sensitive charge density wave (CDW) phase, positioning it as a compelling system for studying intertwined electronic orders. A central challenge is determining whether the observed charge modulations arise from a triplet pair density wave (PDW) order and, if so, how the anisotropic magnetic field response of triplet superconductivity is manifested in the CDW response. Here, using a scanning tunneling micro...
• Raman imaging of the phycosphere reveals sharp gradients of organic matter exuded by single phytoplankton cells AI翻译
  作者：Landry, Zachary C.; Foffi, Riccardo; Anelli, Valerio; Arosio, Paolo; Gil-Garcia, Marcos; Henshaw, Richard J.; Muller, Oliver; Paccagnan, Giacomo; Schneider, Timo N.; Schubert, Carsten J.; Slomka, Jonasz; Lee, Kang Soo; Zambelli, Tomaso; Zweifel, Sophie T.; Stocker, Roman
  作者单位：University of Southern California; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Warsaw; Ulsan National Institute of Science & Technology (UNIST)
  摘要：Phytoplankton cells exude a wide array of chemicals in the water column, generating a localized microenvironment known as the phycosphere. Although it is now well accepted that the phycosphere mediates interactions between phytoplankton and bacteria, the chemical gradients around individual phytoplankton cells have never been explicitly measured, and their shape has been classically assumed to be set by ideal diffusion. Here we used Raman microspectroscopy to obtain micrometer-scale measuremen...
• A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense AI翻译
  作者：Westermann, Alexander J.; Schock, Alexandra; Ashour, Diyaa Al Din; Wende, Sarah; Skevaki, Chrysanthi; Mack, Elisabeth; Schmeck, Bernd; Linne, Uwe; Herrmann, Thomas; Antonakos, Nikolaos; Florou, Helena; Giamarellos-Bourboulis, Evangelos J.; Weis, Sebastian; Vogel, Jorg; Schulte, Leon N.
  作者单位：University of Wurzburg; Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; University of Wurzburg; University of Wurzburg; Philipps University Marburg; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Philipps University Marburg; Harvard University; Harvard T.H. Chan School of Public Health; University Hospital of Giessen & Marburg; Philipps University Marburg; Justus Liebig University Giessen; Philipps University Marburg; Philipps University Marburg; Philipps University Marburg; University of Wurzburg; National & Kapodistrian University of Athens; Friedrich Schiller University of Jena; Friedrich Schiller University of Jena; Leibniz Association; Hans Knoll Institute (HKI)
  摘要：Macrophages are essential for both, to clear pathogens and preserve tissue homeostasis, yet the molecular regulators of this equilibrium remain incompletely defined. Here, we identify SAILR (survival associated immune-regulatory RNA), a primate-specific long noncoding RNA (lncRNA), as a critical modulator of macrophage viability under infection conditions. SAILR is induced during monocyte-to-macrophage differentiation, but rapidly downregulated upon bacterial challenge in a nuclear factor kapp...
• IL-7-glucose-Aiolos axis orchestrates pathogenic CD8+ T cell function in spondyloarthritis AI翻译
  作者：Akiyama, Mitsuhiro; Alshehri, Waleed; Koroyasu, Mirei; Kaburaki, Tomohiro; Yoshimoto, Keiko; Saito, Koichi; Shimanuki, Kanako; Kaneko, Yuko
  作者单位：Keio University
  摘要：CD8(+) T cells are essential mediators of host defense, whereas their aberrant activation contributes to inflammatory diseases such as spondyloarthritis. The molecular mechanisms governing human CD8(+) T cell effector programming remain incompletely understood. Here, we identify a metabolically distinct subset of human CD8(+) T cells defined by high expression of CXCR3, IL-7R, and GLUT1 and low expression of the transcription factor Aiolos. IL-7-JAK-STAT signaling was associated with increased...