29期

最新文章

• Social evolution and diminished olfactory function in larval honey bees AI翻译
  作者：Peng, Tianfei; Chen, Zhenqing; Cash Ahmed, Amy C.; Feng, Qianlu; Yeo, Seokjin; Han, Hee-Sun; Robinson, Gene E.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Social evolution made larval honey bees dependent on adult colony members for feeding; they are confined to cells in waxen honeycombs and visited about 100 times per day by adult nurse bees. Based on organismal resource conservation theory, we predicted larvae have diminished olfactory capabilities at both the molecular and behavioral levels. Consistent with theory, larvae expressed very low levels of Orco, an essential gene for olfactory receptor (OR) function. By contrast, they showed higher...
• CD64 enables TCR-dependent, MHC-independent CTL cytotoxicity of AML cells AI翻译
  作者：Saxena, Kapil; Hung, Shao-Hsi; Ryu, Esther; Chiu, Yulun; Bermack, Casey; Pan, Ke; Shi, Chunhua; Ortiz, Priscilla; Singh, Shailbala; Konopleva, Marina Y.; Yee, Cassian
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center
  摘要：CD8+ T cell-mediated cytotoxicity classically occurs through engagement of an alpha-beta T cell receptor (TCR alpha beta) with a peptide-class I major histocompatibility complex (pMHC). However, it is also known that cytotoxic CD8+ T lymphocytes (CTLs) can kill tumor cells in a pMHC-independent manner. The relative physiologic contribution and biological significance of pMHC-independent CTL killing remain unclear, and a receptor shared between CTLs and natural killer (NK) cells is generally in...
• Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras AI翻译
  作者：Wang, Ning; Hegde, Shalakha; Tang, Zhichao; Liu, Haiqing; Feng, Gang; Niu, Lili; Liu, Bo; Li, Hanyu; Zhang, Xiaodi; Gadhave, Kundlik; Kumbhar, Ramhari; Jiang, Lan; Liu, Yuqi; Luo, Maxwell; Zhang, Shu; Dawson, Ted M.; Pantelyat, Alexander; Rosenthal, Liana S.; Ying, Mingyao; Mao, Xiaobo; Wang, Jingxin
  作者单位：Johns Hopkins University; University of Chicago; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Kennedy Krieger Institute; Johns Hopkins University
  摘要：alpha-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein, alpha-synuclein (alpha Syn). Lowering soluble alpha Syn levels is a promising therapeutic strategy to limit aggregation and neurotoxicity, but directly targeting this protein is hindered by its intrinsically disordered structure and other factors, such as its conformational heterogeneity and intracellular drug delivery barriers. Consequently, increasing attention...
• Mitofusin-2 in ventral striatal D1 neurons regulates effort-based motivation through sex-specific mitochondrial-synaptic reprogramming AI翻译
  作者：Chioino, Alessandro; Ulgen, Dogukan H.; Zanoletti, Olivia; Guillot de Suduiraut, Isabelle; Maynard, Ashley M.; Sanz, Elisenda; Quintana, Albert; Astori, Simone; Sandi, Carmen
  作者单位：Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne; Autonomous University of Barcelona; Autonomous University of Barcelona; North West University - South Africa
  摘要：Effort-based motivation varies widely across individuals and affects well-being, yet the molecular and neuronal mechanisms that set motivational capacity remain incompletely understood. Mitochondrial function is emerging as a critical regulator of behavior, and mitofusin-2 (MFN2) is a key mediator of mitochondrial fusion and endoplasmic reticulum-mitochondria coupling. Here, we asked how downregulation of Mfn2 in dopamine receptor type-1-expressing medium spiny neurons (D1-MSNs) contributes to...
• Spatiotemporally controlled matrix softening facilitates deterministic crypt formation in human intestinal organoids AI翻译
  作者：Blatchley, Michael R.; Bera, Kaustav; Petrich, Nolan R.; Kirkpatrick, Bruce E.; Yavitt, F. Max; McGrath, Patrick S.; Dempsey, Peter J.; Anseth, Kristi S.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Anschutz
  摘要：Spatially controlling morphogenesis is a challenge for many organoid systems that manifests as a limited understanding of self-organization of differentiating cells and leads to a high degree of heterogeneity in organoid morphometrics. Current methods to grow organoids rely on temporal presentation of soluble cues that are not controllably delivered, and little is known about the role of the extracellular microenvironment in this process. Here, we present a material-based strategy to spatiotem...
• Fly navigational responses exploit plume-specific odor motion and gradient cues AI翻译
  作者：Brudner, Samuel; Zhou, Baohua; Jayaram, Viraaj; Madeira Santana, Gustavo; Crimaldi, John P.; Clark, Damon A.; Emonet, Thierry
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; University of Colorado System; University of Colorado Boulder
  摘要：Odor cues guide animals to food and mates. Different environmental conditions can create differently patterned odor plumes, making navigation more challenging. Prior work has shown that animals turn upwind when they detect odor and cast crosswind when they lose it. Animals with bilateral olfactory sensors can also detect directional odor cues, such as odor gradient and odor motion. It remains unknown how animals use these two directional odor cues to guide crosswind navigation in odor plumes w...
• Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice (vol 111, pg 10329, 2014) AI翻译
  作者：Stohr, Jan; Condello, Carlo; Watts, Joel C.; Bloch, Lillian; Oehler, Abby; Nick, Mimi; DeArmond, Stephen J.; Giles, Kurt; DeGrado, William F.; Prusiner, Stanley B.
• Super-Darcy flow behavior in fracture-confined porous media AI翻译
  作者：Zhang, Shuai; Ma, Qing; Xie, Weiqiang; Liu, Kai; Su, Yanlin; Zhao, Mingxin; Wang, Zefan; Zhao, Jinpeng; Liu, Xiaoli
  作者单位：China Institute of Water Resources & Hydropower Research; Tsinghua University; Ministry of Water Resources; Tsinghua University; University of Science & Technology Beijing; University of Science & Technology Beijing; Xizang Agricultural & Animal Husbandry University
  摘要：Particle deposition and migration within fractures can reorganize open void space into heterogeneous fracture-confined porous media (FCPM), yet the macroscopic flow behavior of these emergent systems remains unresolved. Here, Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) simulations were used to resolve particle migration and deposition, whereas a coupled free-flow and seepage-flow model was employed to characterize fluid flow in FCPM. We find that at a fixed Reynolds number, ...
• Cryogenic silicification enables nongenetic functional continuity across mammalian cell generations AI翻译
  作者：Cao, Jiangfan; Ruan, Ting; Li, Zeyu; Tian, Zhouping; Guo, Sishi; Yang, Junxian; Lei, Qi; Jiang, Lingxiang; Guo, Jimin; Brinker, C. Jeffrey; Zhu, Wei
  作者单位：South China University of Technology; Guangzhou Medical University; South China University of Technology; Beijing University of Chemical Technology; University of New Mexico; University of New Mexico; South China University of Technology
  摘要：Mammalian cells are intrinsically soft, with Young's moduli typically ranging from 0.1 to 10.0 kPa depending on the organization of the F-actin cytoskeleton, rendering them highly susceptible to mechanical and environmental stresses. This inherent fragility severely constrains their manipulation and functional deployment under nonphysiological conditions. Here, we report a cryogenic dormancy-enabled silicification strategy that achieves deep integration of inorganic silica reinforcement within...
• Divergent philosophical commitments in neuroscience: Evidence from a global survey AI翻译
  作者：Navarro-Pena, Fabian; Arrondo, Gonzalo; Barrett, Nathaniel F.; Guell, Francisco; Madirolas, Gabriel; Murillo, Jose Ignacio; Sanchez-Canizares, Javier; Bernacer, Javier
  作者单位：Centre National de la Recherche Scientifique (CNRS); Communaute d'universites et etablissements de Toulouse (Comue); Universite de Toulouse (EPE)
  摘要：The mind-brain relationship is a foundational yet underexplored dimension of contemporary neuroscience, shaping research framing, data interpretation, and public communication. We conducted a large-scale international survey of 2,657 neuroscientists to assess their views on the mind-brain problem, free will, and the future of the discipline. Our results reveal a complex and sometimes paradoxical worldview. While 64% of participants endorse reductive physicalism-the view that mental activity is...