-
作者：Otero-Millan, Jorge
作者单位：University of California System; University of California Berkeley
-
作者：Seiler, Jana; Ulbricht, Pia; Sommer, Vivien; Metzger, Sabine; Grunewald, Bernd; Beye, Martin
作者单位：Heinrich Heine University Dusseldorf; University of Cologne
摘要：Social insects exhibit distinct age-dependent behavioral repertoires that collectively contribute to the common benefits of a colony. However, how the nervous system manifests the capacity of such age-dependent, disparate behavioral repertoires underlying the division of labor is largely unknown. In honeybee (Apis mellifera), a classical model of such age-dependent polyethism, young but not older worker bees attend and feed the queen (retinue behavior), which is triggered by the queen mandibul...
-
作者：Tang, Lan; Wu, Run-Jie; Li, Hong-Yu; Wei, Hong-Rui; Duan, Jing-Bo; Lou, Qianqian; Li, Le-Xian; Yang, Xin-Lu; Gao, Wei; Zhu, Min; Zhang, Zhi; Qun, Sen; Kai, Yuanzhong; Jin, Yan
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui Medical University; Anhui Medical University; Anhui University
摘要：Drinking water is a rapid, instinctive behavior of mammals following stress. The role of such stress-induced water drinking behavior and its neural mechanisms remain poorly known. Here, we identify two sequentially activated neural circuits that respectively mediate stress-induced drinking behavior and reward encoding, which collectively promote the extinction of anxiety-like behaviors in mice. Specifically, mild short-term stress induces anxiety-like behaviors and activates glutamatergic neur...
-
作者：Kelly, Emma T. R.; Myziuk, Iryna; Hemmings, Mark Z.; Mulla, Zahi; Blanchet, Jonathan; Ruzzini, Antonio; Berghuis, Albert M.
作者单位：McGill University; McGill University; University of Saskatchewan; University of Saskatchewan; McGill University
摘要：Macrolides are an antibiotic class widely used in both human and veterinary medicine, and function by interfering with protein synthesis. Regrettably, numerous strategies for evading the antibiotic properties of macrolides have been found in bacteria, including enzyme-mediated inactivation. These mechanisms are now widely disseminated among pathogenic, animal-associated, and environmental bacteria making them a One Health issue. Macrolide esterases, which hydrolyze the macrolactone's ester bon...
-
作者：Yatim, Siti Maryam J. M.; Woo, Linda Jiabao; Chen, Yuhong; Hubner, Barbara; Ludwig, Alexander
作者单位：Nanyang Technological University; Nanyang Technological University
摘要：The Hippo pathway governs cell growth, proliferation, and differentiation and is frequently deregulated in cancer. Yes-associated protein (YAP) is the central transcriptional coactivator of the Hippo pathway and interacts with beta-catenin to coordinate YAP-Wnt signaling crosstalk. Both pathways are modulated by diverse upstream signals including mechanical cues, cell density, and cell polarity, yet how such signals are integrated remains poorly understood. Here, we demonstrate that Homer scaf...
-
作者：Dilly, Emilien; Derr, Julien; Zanchi, Drazen
作者单位：Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS)
摘要：We present experimental results on the writhing dynamics of cucumber plant tendrils subjected to an axial traction force. At low forces, the tendrils' curvature saturates exponentially in time at a limiting value. At forces higher than the critical threshold, the tendril fails to coil but develops an intrinsic coiling-prone stress, corresponding to an intrinsic residual curvature, visible if the load is released. Growth-field assessments indicate that curvature arises from differential growth....
-
作者：Hirakawa, Ryota; Hisamatsu, Motoshi; Maekawa, Sayoko; Asai, Eiki; Ohta, Miyuko; Matsuo, Ayumi; Okano, Kunihiro; Miyazaki, Toh; Akiyama, Motofusa; Toyomizu, Masaaki; Islam, Jahidul; Furukawa, Mutsumi; Nochi, Tomonori
作者单位：Tohoku University; Tohoku University; Tohoku University; Akita Prefectural University; University of Tokyo; University of Guelph; Taipei Medical University
摘要：The bursa of Fabricius (BF), a specialized lymphoid structure in birds, regulates avian B-cell development. However, the BF starts to regress posthatching, suggesting that as-yet-unidentified structures assume this function during maturation. This study reveals that BF-independent B-cell genesis involving the gut cecal tonsils (CTs) predominates over the BF-dependent pathway posthatching. Although B-cell progenitors originating from the bone marrow (BM) typically migrate to the BF, we identifi...
-
作者：Qiao, Benjiang; Wu, Lingzhi; Chen, Limin; Huang, Jinyan; Zhang, Pumin; Li, Qiaoran
作者单位：Zhejiang University; Zhejiang University; Zhejiang University
摘要：The sense of taste is essential as it governs appetite and the feeding process. However, it is largely unknown whether and how tumors in a host communicate with peripheral taste sensing. Using the well-established ykiS168A tumor models in Drosophila melanogaster, we found that flies carrying brain or gut tumors exhibit enhanced avoidance of bitter compounds such as caffeine but showed no avoidance of sucrose, and the degree of the avoidance was correlated with severity of the tumor phenotype. ...
-
作者：Sandin, Miguel M.; Cohen, Phoebe A.; Morlon, Helene; Burki, Fabien
作者单位：Uppsala University; Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Universite PSL; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure (ENS)
摘要：Molecular clock and preservation of early microfossil assemblages suggest that eukaryotes were present and already diverse more than similar to 1600 million years ago (Ma). Yet, the earliest identifiable eukaryotic crown group fossil only appeared around 1050 Ma, leaving a similar to 600 My gap in the Mesoproterozoic during which the evolution and diversification of early eukaryotes remain poorly understood. Here, we infer a timeline of eukaryote evolution using molecular clock and birth-death...
-
作者：Wang, Jing; Liu, Wei; Sun, Jiamei; Wu, Jianguo; Bai, Yongfei; Huang, Jianhui; Wang, Qibing; Elser, James J.; Wang, Xiaoliang; Han, Xingguo; Pan, Qingmin
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Botany, CAS; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Montana System; University of Montana; Hebei University
摘要：The biodiversity-productivity relationship (BPR) is crucial for understanding the consequences of biodiversity loss; yet, how this relationship evolves over time in natural ecosystems remains unclear. Several long-term biodiversity experiments with artificially assembled communities suggest that the BPR escalates over time, however, whether this pattern applies to natural ecosystems has not been explored. Here, we present the results of a 15-y removal experiment in the Inner Mongolia grassland...
