29期

最新文章

• Pseudokinase-converting mutation in protein kinase C alpha drives chordoid glioma by pathway rewiring AI翻译
  作者：Bellamy, Charlotte; Tovell, Hannah; Kao, Tiffany H.; Kornev, Alexandr; Letourneur, Quentin; Arslan, Janan; Schwaighofer, Selina; Baffi, Timothy R.; Dingli, Florent; Loew, Damarys; Lerond, Julie; Liva, Stephane; Izac, Brigitte; Andrieu, Muriel; Adle-Biassette, Homa; Barnier, Jean-Vianney; Stefan, Eduard; Taylor, Susan S.; Sanson, Marc; Newton, Alexandra C.; Bielle, Franck
  作者单位：Centre National de la Recherche Scientifique (CNRS); Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Hopital Universitaire Pitie-Salpetriere - APHP; University of California System; University of California San Diego; University of California System; University of California San Diego; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Centre for Eye Research Australia; University of Melbourne; Royal Victorian Eye & Ear Hospital; University of Innsbruck; University of Innsbruck; UNICANCER; Universite PSL; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; Institut Curie; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Hopital Universitaire Charles-Foix - APHP; Hopital Universitaire Pitie-Salpetriere - APHP; Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Hopital Universitaire Charles-Foix - APHP; Hopital Universitaire Pitie-Salpetriere - APHP; Cornell University; Weill Cornell Medicine; Pfizer; Pfizer USA
  摘要：Chordoid glioma (ChG) is a rare, low-grade brain tumor characterized by a novel recurrent point mutation, D463H, in the kinase domain of protein kinase C alpha (PKC alpha). The mutation is invariably an Asp to His substitution, suggesting a unique function beyond catalytic inactivation associated with other cancer-associated PKC alpha mutations. Here, we show that this mutation converts PKC alpha into a pseudokinase, abolishing catalytic activity, and, additionally, confers novel scaffolding f...
• BRCA1P1 immunotherapy requires pseudogene-aware transcriptomics AI翻译
  作者：Chi, Hao; Xu, Jiayu; Deng, Youping
  作者单位：University of Hawaii System; University of Hawaii Manoa; Cardiff University
• The accuracy of electrostatic interactions captured by AI protein structure prediction models AI翻译
  作者：Makhatadze, George I.
  作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute
  摘要：A variant of the U1A protein containing four substitutions to ionizable residues was generated serendipitously due to a miscommunication. Biophysical measurements reveal this variant has twice the helical structure of wild-type U1A and is trimeric, unlike the monomeric wild type. In sharp contrast, structures predicted by deep-learning (AlphaFold2, RoseTTAFold2) and transformer-based tools (OmegaFold, ESMFold) are nearly identical to the wild-type (backbone RMSD < 1 & Aring;). Surprisingly, th...
• Zero-deforestation commitments in Indonesia's palm oil sector achieve high compliance but no additionality AI翻译
  作者：Stigler, Matthieu; Grabs, Janina; Heilmayr, Robert; Carlson, Kimberly M.; Chandra, Adelina; Benedict, Jason Jon; Garrett, Rachael D.
  作者单位：University of Geneva; University of Basel; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; New York University; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Cambridge
  摘要：In response to public pressure, companies have increasingly adopted voluntary sustainable sourcing commitments. Yet, it often remains unclear whether such commitments lead only to the narrow goal of supplier compliance, or also to the broader goal of additionality, benefits beyond what would have occurred without commitments. A company's ability to influence its suppliers' behavior partly depends on the complexity of supply chains, yet data on supply chain linkages are limited, inhibiting caus...
• Goal-directed modulation of the default network supports interactions between selective attention, working memory, and prior knowledge AI翻译
  作者：Diveica, Veronica; Setton, Roni; Turner, Gary R.; Spreng, R. Nathan
  作者单位：McGill University; Harvard University; York University - Canada; McGill University; McGill University; McGill University
  摘要：Memory is central to flexible, goal-directed behavior. Prior knowledge shapes our current decisions and future plans and guides our attention to selectively prioritize relevant information in our complex, noisy world. Yet, most research on the neural basis of selective attention has focused on novel stimuli and has defined goal relevance based on perceptual features rather than prior knowledge. We investigated how the brain supports selective attention when goal relevance depends on prior know...
• Crowding controls the scaling of bus frequency with demand AI翻译
  作者：Patwardhan, Siddharth; Erkol, Sirag; Radicchi, Filippo; Barthelemy, Marc
  作者单位：Northwestern University; Indiana University System; Indiana University Bloomington; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS)
  摘要：Cities must allocate limited resources to maintain mobility, with uncertainties about the resulting state of the system. Analyzing roughly 3,000 bus routes with more than 4 billion yearly riders across 19 metropolitan areas worldwide, we uncover a robust scaling law of the form f similar to(d/t)alpha with exponent alpha is an element of[1/2,2/3], linking the service frequency f to passenger demand d and route duration t. We show that this scaling emerges from a simple optimization principle: C...
• Alpha rhythms in the left auditory cortex set the speed limit for speech comprehension AI翻译
  作者：Gao, Yayue; Fan, Jianing; Xu, Na; Zhao, Libo; Deng, Lifang; Yang, Ruolin; Chen, Luyao; Jing, Zhiwei; Huang, Tingting; Wang, Xiongfei; Wang, Jing; Teng, Pengfei; Cai, Peng; Luan, Guoming; Du, Yi; Wang, Qian; Fang, Fang
  作者单位：Beihang University; Peking University; Peking University; Peking University; Peking University; Beijing Jiaotong University; Beihang University; Beihang University; Capital Medical University; Capital Medical University; Capital Medical University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Psychology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Peking University; Peking University
  摘要：Human cognition operates within distinct temporal windows spanning from very short to extremely long. Each cognitive function has its own processing speed range, beyond which performance deteriorates or even becomes impossible. Speech comprehension, as one of the most important cognitive functions in civilized societies, exemplifies this constraint: Performance declines markedly when speech rates exceed about 10 syllables per second. However, the neural mechanisms underlying this speed limit r...
• Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by αvβ3 and α5β1 integrins (vol 100, pg 4766, 2003) AI翻译
  作者：Sudhakar, Akulapalli; Sugimoto, Hikaru; Yang, Changqing; Lively, Julie; Zeisberg, Michael; Kalluri, Raghu
• Sequential evolution of antidote and toxin links genetic incompatibility with immune responses AI翻译
  作者：Xie, Dongying; Ma, Yiming; Zeng, Junhui; Ye, Pohao; Zhao, Zhongying
  作者单位：Hong Kong Baptist University; Hong Kong Baptist University; Hong Kong Baptist University
  摘要：Toxin-antidote (TA) systems are selfish genetic elements that ensure their own inheritance by eliminating offspring that do not inherit the module, thereby creating postzygotic genetic incompatibilities both within and between species. Despite their ubiquity and substantial fitness costs, the origin and persistence of TA systems remain poorly understood. Here, we report a TA gene pair in the nematode Caenorhabditis nigoni. The antidote gene, Cni-shls-2, is a C. nigoni-specific F-box gene that ...
• Paintable on-skin dry electrodes with robust skin and device connection for wireless sensing and human-machine interfaces AI翻译
  作者：Zhang, Wanqing; Xin, Xin; Wang, Yuqi; Zhang, Xianzhe; Zhang, Senhao; Yuan, Yangbo; Xia, Shihao; Abdullah, Abu Musa; Zohra, Fatema Tuz; Li, Bowen; Yang, Jia-Yu; Dutta, Ankan; Liu, Zhuo; Lima, Anna Beatriz Pacheco; Yan, Su; Zhong, Jun; Chuang, Cheng-Hsin; Cheng, Huanyu
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; City University of Hong Kong; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Drexel University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; National Sun Yat Sen University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Chinese Academy of Sciences; Suzhou Institute of Biomedical Engineering & Technology, CAS
  摘要：Reliable and continuous electrophysiological recording is important for health monitoring and human-machine interactions. However, most existing epidermal electrodes suffer from either limited skin-electrode contact during skin deformation and sweating, or unstable connections between soft electrodes and relatively rigid data acquisition systems due to the inherent mechanical mismatch. Besides, their lack of personalization further discourages long-term use, particularly among children, adoles...