-
作者：Parker, Darren J.; Dumas, Zoe; Gomez, Rocio; Aury, Jean-Marc; Labedan, Marjorie; Tran Van, Patrick; Istace, Benjamin; Cruaud, Corinne; Labadie, Karine; Noel, Benjamin; Freitas, Susana; Djordjevic, Jelisaveta; Schwander, Tanja
作者单位：Bangor University; University of Lausanne; Autonomous University of Madrid; CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Paris Saclay
摘要：Dosage compensation and meiotic sex chromosome inactivation (MSCI) are key mechanisms regulating gene expression from the X chromosome in male-heterogametic species. While the convergent evolution of these mechanisms is well documented, their evolutionary fate under relaxed selection remains poorly understood. Here, we test whether dosage compensation and MSCI persist following three independent transitions to parthenogenesis in stick insects, where selection on male phenotypes is relaxed. Usi...
-
作者：Schnyder, Simon K.; Lynch, Mark P.; Molina, John J.; Yamamoto, Ryoichi; Turner, Matthew S.
作者单位：University of Tokyo; University of Warwick; Kyoto University; University of Warwick
-
作者：Zhou, Hanbei; Goh, Rui Zhe; Phillips, Ian; Firestone, Chaz
作者单位：Johns Hopkins University; Johns Hopkins University
摘要：The timing of behavioral responses is among the most robust signatures of cognitive processing-with easier, more accurate, and more confident judgments typically made more quickly. But which aspects of response timing carry these signals? Whereas the time taken to initiate a response (e.g., the interval between stimulus onset and keypress) is one of the most popular and informative measures in experimental psychology, another aspect of response timing is its duration (e.g., how long the key is...
-
作者：Cao, Guan-Long; Li, Xiao-Qian; Zhang, Jun; Peng, Huan-Wen; Li, Hong-Lei; Erst, Andrey S.; Jabbour, Florian; Ortiz, Rosa del C.; Soltis, Pamela S.; Soltis, Douglas E.; Wang, Wei
-
作者：Hedden, Matthew; Raoux, Katherine
作者单位：Michigan State University; University of Arkansas System; University of Arkansas Fayetteville
摘要：We establish a criterion that ensures a bounded almost complex curve in a bounded almost complex 4-manifold minimizes genus among all smooth surfaces that share its homology class and the transverse link on its boundary. An immediate corollary affirms the relative symplectic Thom conjecture and, moreover, yields obstructions coming from knot Floer homology to a link bounding a symplectic surface in a symplectic filling. Our results are applicable to knots in manifolds equipped with plane field...
-
作者：Zhao, Yingqi; Hu, Xiaoyun; Li, Yalun; Zhang, Jing; Guo, Hao; Zhang, Yuying; Wu, Ting; Guo, Jinyu; Peng, Yi; Che, Ying; Zhu, Xianglong; Chen, Qiuchen; Grieve, David; Wei, Minjie; Wu, Huizhe
作者单位：China Medical University; China Medical University; China Medical University; Queens University Belfast
摘要：Small nucleolar RNAs (snoRNAs) play crucial regulatory roles in various cancers. However, the mechanisms by which snoRNAs regulate N6-methyladenosine (m(6)A) modifications in colorectal cancer (CRC) remain unclear. This study systematically deciphered the precise interaction mechanism between SNORD78 and the m(6)A reader IMP2 in CRC. We demonstrate that SNORD78 specifically stabilizes IMP2 to activate the PIK3CD-CHKA-Kennedy pathway in an m(6)A-dependent manner, promoting endoplasmic reticulum...
-
作者：Khursheed, Anum; Shang, Qi; Zhang, Hui; Tian, Yao; Szwedziak, Piotr; Volkov, Vladimir A.; Viles, John H.
作者单位：University of London; Queen Mary University London; South Central Minzu University; University of Zurich
摘要：Central to Alzheimer's disease pathology are prefibrillar oligomer assemblies of amyloid-beta (A beta) peptide. A widely discussed hypothesis proposes that amyloid-beta oligomers insert into neuronal lipid membranes, disrupting their integrity and causing a loss of cellular homeostasis in Alzheimer's disease. This membrane disruption is believed to be a major source of A beta-induced neurotoxicity. Cryo electron tomography (cryo-ET) has facilitated 3D nanoscale imaging of A beta-membrane inter...
-
作者：Burton, William J.; Lin, Alice; Morgan, Anthony J.; Davis, Lianne C.; Chen, Cheng-Chang; Galione, Antony
作者单位：University of Oxford; National Taiwan University; National Taiwan University; National Taiwan University Hospital
摘要：Two-pore channel 1 (TPC1) is an endosomal Na+/Ca2+-selective channel implicated in membrane trafficking, endosome tubulation, and excitability, but how TPC1 regulates membrane trafficking is unknown. Using TPC1-null human cells, we demonstrate that TPC1 drives transferrin receptor (TfR) trafficking and recycling via Ca2+, and not Na+ fluxes or endosomal pH changes, since channel-targeted Ca2+-buffers inhibited trafficking, whereas a Na+-deficient Ca2+-permeable TPC1 mutant fully supported traf...
-
作者：Runyon, Alexander; Zhang, Peizhao; Fischer, Andy J.; Nonet, Michael L.; Lillesaar, Christina; Ye, Lihua
作者单位：University System of Ohio; Ohio State University; Washington University (WUSTL); University of Wurzburg
摘要：The vagal sensory nervous system plays important roles in mediating gut-brain communication and maintaining physiological homeostasis. Although recent research has greatly enhanced our understanding of the function of vagal sensory neurons, little is known about what guides the vagal sensory nerve fibers to innervate the intestine and form a complex gut-brain sensory network. Here, using zebrafish genetic models to trace the development of the intestinal vagal network, we found that the develo...
-
作者：Sueto, Daichi; Uchiyama, Sawako; Ono, Teruaki; Watanabe, Moeka; Sekine, Misuzu; Nishida, Yuto; Nomaki, Kohei; Shibata, Yuto; Tashima, Ryoichi; Fujimori, Kazuki; Nakashima, Yasuharu; Tsuda, Makoto
作者单位：Kyushu University; Kyushu University; Kyushu University
摘要：When exposed to noxious cutaneous stimuli, animals exhibit nocifensive behaviors, including rapid defensive reflexes that limit tissue damage and subsequent coping behaviors-most commonly licking of the affected area-that alleviate pain. Despite its ubiquity, the neural mechanism underlying pain relief through licking remains poorly understood. Here, we demonstrate that Npy2r-Cre(+) primary sensory neurons in the dorsal root ganglion (DRG), a population of A beta fibers that includes touch-sen...
