29期

最新文章

• Distinct cell type-specific mechanisms underlie cognitive dysfunction during persistent integrated stress response activation AI翻译
  作者：Torkenczy, Kristof; Reineke, Lucas C.; Dooling, Sean W.; Henderson, Benjamin W.; Yang, Benjamin; He, Dongze; Myers, Richard M.; Walter, Peter; Tyanova, Stefka; Costa-Mattioli, Mauro
  作者单位：HudsonAlpha Institute for Biotechnology; Baylor College of Medicine; Buck Institute for Research on Aging
  摘要：Persistent activation of the integrated stress response (ISR) is a central driver of cognitive decline in both neurodevelopmental and neurodegenerative disorders. However, the cell type-specific mechanisms underlying these deficits remain poorly understood. By integrating single-cell RNA-seq and single-cell assay for transposase-accessible chromatin sequencing, we generated a brain ISR atlas using Ppp1r15bR658C mice, a clinically relevant model of intellectual disability characterized by selec...
• ROS produced in mitochondria entrapped by self-assembly peptide fibers for target therapy of glioma AI翻译
  作者：Zhang, Suling; Yu, Fanchen; Yang, Yang; Jia, Yi; Xu, Yongqiang; Zhou, Jin; Qiao, Zeng-Ying; Lu, Jin; Li, Chunmei; Wang, Hao; Li, Junbai
  作者单位：Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS
  摘要：Brain glioma is a highly energy-dependent malignant tumor. Sonodynamic therapy (SDT) provides a noninvasive and effective approach for brain glioma therapy. Reactive oxygen species (ROS) from sonosensitizers in the treatment of SDT play a key role. Inspired by spider webs, a self-assembling spider peptide (P1) bearing porphyrin moieties was constructed to generate ROS under ultrasound. In glioma cells, P1 forms web-like nanofibers that weave around mitochondria and enables ROS to release in si...
• Polarons are probes of the dynamic nanoscale environments found in electrochemically doped π-conjugated polymers AI翻译
  作者：Brown, Megan R.; Chen, Zhiting; Magni, Arianna; Li, Hong; Bombile, Joel H.; Suo, Sa; Lian, Tianquan; Myong, Michele S.; Bredas, Jean-Luc; Bird, Matthew J.; Armstrong, Neal R.; Salleo, Alberto; Ratcliff, Erin L.; Risko, Chad
  作者单位：University of Kentucky; University of Kentucky; University of Arizona; Stanford University; Emory University; United States Department of Energy (DOE); Brookhaven National Laboratory; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
  摘要：Charge carriers (i.e., polarons) in electrochemically doped organic (semi)conductors are proposed to be regulated by several physicochemical features, including the chemical compositions and structures of the pi-conjugated frameworks of the semiconductor building blocks, the chemistry of the electrolyte (considering both the salt and solvent), multiscale and time-dependent morphology variations across the material as a function of electrochemical processes, and assorted permutations of these a...
• Artistic visions shape and respond to Mars missions AI翻译
  作者：Mann, Adam
• Disentangling dissociative and nondissociative reaction dynamics in molecular mutual neutralization reactions between CO+ and O- AI翻译
  作者：Poline, Mathias; Dochain, Arnaud; Rosen, Stefan; Ji, MingChao; Reinhed, Peter; Simonsson, Ansgar; Cederquist, Henrik; Zettergren, Henning; Schmidt, Henning T.; Larsson, Mats; Ard, Shaun G.; Shuman, Nicholas S.; Viggiano, Albert A.; Thomas, Richard D.
  作者单位：Stockholm University; Universite Catholique Louvain; United States Department of Defense; United States Air Force; US Air Force Research Laboratory
  摘要：We have studied the mutual neutralization reaction of CO+ with O- at a collision energy of <= 0.1 eV under single-collision conditions. We observe both fully dissociative (31.5 +/- 1.8 %) and nondissociative (68.5 +/- 1.8 %) charge transfer, involving at least five different electronically excited states in CO. From product momentum analysis, we find that the dynamics are governed by electron transfer processes at large O--CO+ separations and the competition between predissociation and radiati...
• Repurposing trazodone for Alzheimer's disease to modulate soluble ST2 levels and alleviate Alzheimer's pathology AI翻译
  作者：Wong, Daniel Y. K.; Fu, Wing-Yu; Uhm, Hyebin; Jiang, Yuanbing; Yip, Yuki C. C.; Mok, Vincent C. T.; Kwok, Timothy C. Y.; Ouyang, Li; Fu, Amy K. Y.; Ip, Nancy Y.
  作者单位：Hong Kong University of Science & Technology; Chinese University of Hong Kong; Chinese University of Hong Kong; Shenzhen Research Institute, The Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS
  摘要：Alzheimer's disease (AD) is a multifactorial disorder involving various pathological mechanisms, such as amyloidosis, immune dysfunctions, and synaptic impairments, which are important therapeutic targets. Repurposing drugs to target these mechanisms offers a promising approach to reduce the costs and duration of drug development. Genetic studies underscore the critical role of microglial clearance of amyloid-beta (A beta) in AD pathogenesis. Specifically, soluble ST2 (sST2)-one of the two maj...
• A reassessment of NMDA receptor-dependent presynaptic homeostatic plasticity AI翻译
  作者：Chen, Xiumin; Dou, Tianli; Zhang, Junting; Hong, Yidan; Nicoll, Roger A.
  作者单位：Soochow University - China; Soochow University - China; Soochow University - China
  摘要：Excitatory glutamatergic synapses in the brain are remarkably plastic. Two forms of plasticity have received the most attention: long-term potentiation (LTP) and synaptic homeostasis. While LTP requires the activation of NMDA receptors, synaptic homeostasis does not. However, both phenomena are mediated by the recruitment of postsynaptic AMPA receptors (AMPAR) to the synapse. Recently a new form of plasticity has been described referred to as presynaptic homeostatic plasticity (PHP). Pharmacol...
• Structural basis of membrane engagement and polyreactivity control in HIV-1 MPER broadly neutralizing antibodies AI翻译
  作者：Cho, So Yeon; Rantalainen, Kimmo; Ozorowski, Gabriel; Lu, Danny; Tingle, Ryan; Lee, Wen-Hsin; Ward, Andrew B.; Schief, William R.; Wilson, Ian A.
  作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Scripps Research Institute
  摘要：The membrane-proximal external region (MPER) of HIV-1 Env represents a critical target for broadly neutralizing antibodies (bnAbs) due to its conservation and functional importance. However, MPER-targeting bnAbs recognize composite epitopes comprising peptide and viral membrane lipid components, creating an inherent tension between viral neutralization efficacy and polyreactivity. 10E8-class antibodies exhibit high neutralization potency with low polyreactivity, whereas 4E10-class antibodies s...
• Reply to Rana and Singh: Critical thresholds and critical actions for evolvable AI AI翻译
  作者：Muller, Viktor; Steels, Luc; Szathmary, Eors
  作者单位：Eotvos Lorand University; Eotvos Lorand University
• Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase AI翻译
  作者：Obara, Keisuke; Okada, Hiroki; Tan, Guihong; Ohnuki, Shinsuke; Suzuki, Godai; Ohtake, Haruka; Kubo, Karen; Ghanegolmohammadi, Farzan; Ishizaka, Shunsuke; Yashiroda, Yoko; Okita, Aoi; Mishiro-Sato, Emi; Suzuki, Kuninori; Tamura, Yasushi; Ashine, Rei; Ikeda, Yoshiki; Kamura, Takumi; van Leeuwen, Jolanda; Andrews, Brenda; Bi, Erfei; Noda, Nobuo N.; Boone, Charles; Ohya, Yoshikazu
  作者单位：Nagoya University; University of Tokyo; University of Pennsylvania; Pennsylvania Medicine; University of Toronto; RIKEN; Nagoya University; Yamagata University; Kyoto University; Hokkaido University; Nagaoka University of Technology; University of Tokyo
  摘要：The biogenesis of multipass membrane proteins challenges the endoplasmic reticulum (ER) quality control, particularly when transmembrane segments contain polar or charged residues required for function. Fks1, the catalytic subunit of yeast beta-(1,3)-glucan synthase, exemplifies this challenge because its large multipass transmembrane architecture must support glucan synthesis at the plasma membrane while also undergoing efficient biogenesis in the ER. Here, we investigate the cellular role of...