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作者：Glaubitz, Alina; Fu, Feng
作者单位：Dartmouth College; Dartmouth College
摘要：Understanding the origins of volunteerism and free-riding is crucial in collective action situations where a sufficient number of cooperators is necessary to achieve shared benefits, such as in vaccination campaigns and social change movements. Despite the importance of attaining behavioral consistency for successful collective action, the theoretical mechanisms behind this process remain largely elusive. Here, we address this issue by studying the evolutionary dynamics of individual cooperati...
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作者：Meincke, Lennart; Shapiro, Dan; Duckworth, Angela L.; Mollick, Ethan; Mollick, Lilach; van den Bulte, Christophe; Cialdini, Robert
作者单位：University of Pennsylvania; WHU - Otto Beisheim School of Management; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Arizona State University; Arizona State University-Tempe
摘要：Are large language models (LLMs) susceptible to the same persuasive appeals as humans? We tested whether classic persuasion principles (authority, commitment, liking, reciprocity, scarcity, social proof, and unity) could induce three widely used LLMs (GPT-5 mini, Claude Haiku 4.5, and Gemini 3 Flash) to comply with requests to assist with the synthesis of regulated substances. Across 126,000 conversations, persuasion principles increased compliance from 35.3% (at baseline) to 51.3% (using any ...
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作者：Deichler, Alfonso; Ruiz-Flores, Macarena; Marquez, Natalia I.; Morales, Cristian; Lopez-Jury, Luciana; Vega-Zuniga, Tomas; Mpodozis, Jorge; Faunes, Macarena; Marin, Gonzalo J.
作者单位：Universidad de Chile; Pontificia Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile; Universidad Finis Terrae
摘要：Binocular vision requires both eyes to be aligned such that their visual fields overlap. A long-standing premise derived from comparative studies is that the orientation of the orbits determines eye position, and thereby the extension of this overlap, the binocular field. In addition, to produce an accurate neural representation, the binocular field must integrate with the position of retinal high-acuity areas and with the extent of uncrossed retinal projections. It remains unknown, however, w...
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作者：Park, Seong Kyun; Lee, Jeongha; Park, Seon Ju; Kim, Ye Na; Shin, Gi Hyun; Dan, Kisoon; Choi, Hee-Jung; Han, Dohyun; Hwang, Byung Joon; Choi, Murim
作者单位：Kangwon National University; Seoul National University (SNU); Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU)
摘要：Numerous proteins display pleiotropic functions in different clinical contexts. However, the molecular mechanism underlying such effects is rarely understood. Speckle-type POZ protein (SPOP) is a typical example, exhibiting tumor-suppressing or tumor-promoting effects in different tumor types in accordance with different amino acid changes; specifically, two distinct sets of variants in SPOP are commonly found in subsets of prostate cancer and endometrial cancer patients. To comprehensively ch...
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作者：Rusishvili, Nana; Jalabadze, Mindia; Mosulishvili, Marine; Batiuk, Stephen; Maghradze, David; Boaretto, Elisabetta; Martkoplishvili, Inga; Meladze, Nana; Lordkipanidze, David
作者单位：Ilia State University; University of Toronto; Weizmann Institute of Science; Ivane Javakhishvili Tbilisi State University
摘要：Bread wheat (Triticum aestivum L.) is the most popular wheat species in the world today. However, studies on the domestication of wheat have rarely focused on the evolution of this specific species of Triticum. The discussions that have emerged have focused on the evolution of bread wheat, revealing it to have emerged from the hybridization of an already domesticated free-threshing wheat and the wild goatgrass known as Aegilops tauschii Coss. These studies, however, have focused on the previou...
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作者：Shtyrov, Alexander; Wilson, Hugh; Slowik, Daria; Yamashita, Keitaro; Li, Jade; Wojdyr, Marcin; Chen, Shaoxia; McMullan, Greg; Short, Jude M.; Russo, Christopher J.; Henderson, Richard; Murshudov, Garib N.
作者单位：MRC Laboratory Molecular Biology; University of Tokyo
摘要：Determination of specimen structure from cryoelectron microscopy (cryo-EM) experiments relies on an accurate model of the electrostatic potential of the specimen. For biological macromolecules, the potential is strongly influenced by the presence of chemical bonds between atoms, a fact unaccounted for by models of electron scattering that are currently standard in the field. We propose a Bayesian approach to the estimation of atomic scattering factors which incorporates the effect of the molec...
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作者：Fang, Yuanyuan; Luo, Wenxi; Huang, Hao; Ran, Lusen; He, Yuqin; Cheng, Chang; Yao, Yao; Hou, Yuxiang; Zheng, Haibo; Pan, Dengji; Xu, Shabei; Luo, Xiang; Qin, Tingting; Hao, Xingjie; Lu, Feng; Wang, Wei; Wang, Minghuan
作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology
摘要：The focus of this study is to investigate the role of diffusion tensor imaging along the perivascular space (DTI-ALPS) index in brain aging. To address this, we first examined the association of DTI-ALPS with aging hallmarks among 40,488 UK Biobank (UKB) participants. Next, we developed normative brain age models incorporating the DTI-ALPS index from 12,401 healthy UKB adults and validated in UKB-ADNI and UKB-TALENT datasets. Finally, we explored the relationship between brain age gap (BAG) wi...
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作者：Kelenis, Demetra P.; Johnson, Jeffrey R.; Sidoli, Simone; Emery, Ann; Swanstrom, Ronald; Hawkins, Luke J.; Mckie, Kaila; Pawar, Tegh; Goff, Stephen P.
作者单位：Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Yeshiva University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Columbia University
摘要：SUMOylation is a dynamically regulated post-translational modification involving covalent attachment of small ubiquitin-like modifiers (SUMOs) to lysine residues of target proteins. SUMOylation modulates multiple fundamental host cellular pathways, including pathways hijacked by HIV-1 to enable replication, but has not been explored by large-scale proteomics in the context of HIV-1 infection. Here, we performed a proteome-wide, mass spectrometry-based screen to identify proteins that are SUMOy...
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作者：Shao, Yucai; Suchard, Marc A.; Rambaut, Andrew; Ji, Xiang; Lemey, Philippe; Vasylyeva, Tetyana I.; Baele, Guy
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of Edinburgh; Iowa State University; KU Leuven; University of California System; University of California Irvine
摘要：Advances in molecular epidemiology and computational modeling have improved our ability to track pathogen evolution, but accurate reconstruction of spatiotemporal transmission remains essential for epidemic preparedness and response. Structured coalescent models offer a phylogeographic framework by restricting coalescence to lineages within the same deme. Although the Bayesian structured coalescent approximation (BASTA) provides a tractable approach, contemporary phylogeographic analyses invol...
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作者：Xu, Jianing
作者单位：Regeneron
