2026

最新文章

• Cryopreservation through vitrification enables functional recovery of the mouse hippocampus AI翻译
  作者：Maya-Romero, Alex; Zoncu, Roberto
  作者单位：University of California System; University of California Berkeley
• mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model AI翻译
  作者：Skelly, Ashwin N.; Fan, Chengcheng; Keeffe, Jennifer R.; Okten, Arya B.; Gavor, Edem; Newby, Maddy L.; Allen, Joel D.; Kreider, Edward F.; Ding, Wenge; Osbaldeston, Rebecca A.; Park, Younghoon; Connell, Andrew J.; Lituchy, Melinda G.; Bibollet-Ruche, Frederic; Radford, Katelyn M.; West, Anthony P.; Pena-Hernandez, Mario A.; Cruickshank, Kendra; Liu, Weimin; Li, Yingying; Albertus, Amie; McWilliams, Brieyanna; Russell, Ronnie M.; Konrath, Kylie M.; Torres, Jonathan L.; Yuan, Meng; Gao, Hongmei; Montefiori, David C.; Saag, Michael S.; Goepfert, Paul A.; Kulp, Daniel W.; Ward, Andrew B.; Wilson, Ian A.; Shaw, George M.; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Wilen, Craig B.; Bjorkman, Pamela J.; Hahn, Beatrice H.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; California Institute of Technology; Yale University; Yale University; University of Southampton; The Wistar Institute; Scripps Research Institute; Duke University; Duke University; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
  摘要：The unyielding antigenic drift of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as the threat of future zoonotic sarbecovirus spillovers, has prompted the search for broadly neutralizing antibodies (bNAbs) to inform rational therapeutic and vaccine design. Here, we isolated and characterized 20 receptor binding domain (RBD)-directed bNAb lineages from a serially sampled SARS-CoV-2 patient who was infected and vaccinated during the early months of the pandemic. Thirteen ...
• General inverse-cube thickness scaling of projectile penetration energy in ultrathin films AI翻译
  作者：Zaccone, Alessio; Sirk, Timothy W.
  作者单位：University of Milan
  摘要：Ultrathin films of widely different materials exhibit a dramatic enhancement of projectile penetration resistance under high-velocity impact. Despite extensive simulations and experiments, a unifying physical explanation has remained elusive. Here we show that the specific penetration energy follows a general inverse-cube scaling law, Ep & lowast;(h)=Ep,infinity & lowast;+Bh-3, across chemically and structurally distinct systems. The inverse-cube scaling is traced to a finite-size correction t...
• Social interactions in isolated, confined, and extreme environments: A study of Antarctic winter teams using wearable sensors AI翻译
  作者：Cantisani, Andrea; Schmutz, Jan B.; Marques-Quinteiro, Pedro; Dall'Amico, Lorenzo; Cattuto, Ciro; Antino, Mirko; Eppich, Walter J.; Stegmayer, Katharina; Walther, Sebastian
  作者单位：University of Bern; University Hospital of Bern; University of Zurich; Lusofona University; University of Tras-os-Montes & Alto Douro; Complutense University of Madrid; University of Melbourne; University of Wurzburg
  摘要：Long-duration space missions expose crews to extreme psychological and social stressors due to prolonged isolation and confinement. To examine how such conditions impact individual and team functioning, we studied a 10-mo Antarctic overwintering mission at Concordia Station, an analog for spaceflight, using self-report measures and wearable proximity sensors. Twelve crew members were assessed at four time-points. Results revealed a progressive increase in feelings of loneliness and conflict, w...
• Electrical stimulation promotes longevity and regeneration in a colonial chordate AI翻译
  作者：Domen, Jos; Voskoboynik, Yotam; Levy, Tom; Domen, Erica M.; Ishizuka, Katherine J.; Palmeri, Karla J.; Anselmi, Chiara; Rolander, Thomas; Neff, Norma F.; Detweiler, Angela M.; Weissman, Irving L.; Gandy, Kimberly L.; Sahoo, Debashis; Voskoboynik, Ayelet
  作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford University; University of California System; University of California San Diego; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Endogenous bioelectric currents regulate development and regeneration, but their influence on organismal longevity and stem cell-mediated repair is not well understood. We demonstrate that a brief, clinically safe pulse of electrical current (PEC) produces lasting rejuvenation in the colonial chordate Botryllus schlosseri. In this species where all differentiated tissues are replaced weekly and progenitor populations mediate the weekly de novo generation of new organs, organismal aging is dire...
• Reading ability in both deaf and hearing adults is linked to neural representations of abstract phonology derived from visual speech AI翻译
  作者：Evans, Samuel; Price, Cathy J.; Diedrichsen, Jorn; Twomey, Tae; Beedie, Indie; Fraser, Maggie; MacSweeney, Mairead
  作者单位：University of London; University College London; University of London; University College London; University of London; University College London; Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario)
  摘要：Reading is central to academic and vocational success. Some deaf children face reading challenges due to limited access to spoken or signed language. Robust phonological representations are key to reading development in hearing children. Spoken language phonology may be one of many contributors to reading development in deaf children. Indeed, speechreading ability correlates with reading skill in both deaf and hearing individuals, suggesting it is linked to reading development regardless of he...
• Introduced species will not save Caribbean coral reefs AI翻译
  作者：Ritson-Williams, R.; Mumby, P. J.; Steneck, R. S.
  作者单位：California State University System; California State University Northridge; University of Queensland; University of Maine System; University of Maine Orono
• Remote sensing enables expansion of our understanding of controls on river width and active floodplain AI翻译
  作者：Seminara, Giovanni
  作者单位：University of Genoa
• Neural representations of popularity and leadership status relate to conformity in daily life AI翻译
  作者：Stanoi, Ovidia A.; Cosme, Danielle; Jovanova, Mia; Kang, Yoona; Corbani, Faustine; McGowan, Amanda L.; Carreras-Tartak, Jose; Resnick, Anthony; Bearman, Peter S.; Boyd, Zachary M.; Bassett, Dani S.; Lydon-Staley, David M.; Mucha, Peter J.; Falk, Emily B.; Ochsner, Kevin N.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of St Gallen; Swiss Federal Institutes of Technology Domain; ETH Zurich; Rutgers University System; Rutgers University New Brunswick; Rutgers University Camden; Princeton University; Columbia University; Brigham Young University; University of Pennsylvania; Dartmouth College; University of Pennsylvania; University of Pennsylvania; Columbia University
  摘要：Individuals are motivated to increase their social status. To succeed in this pursuit, people must track information about others in their social sphere, monitor group norms, and adjust their behavior strategically. This study employed functional MRI and ecological momentary assessment methods in a sample of 92 college students belonging to 9 social groups to elucidate the neural mechanisms underlying these processes and their relationship to conformity in the context of alcohol use. When youn...
• Predictions from deep learning propose substantial protein-carbohydrate interplay AI翻译
  作者：Canner, Samuel W.; Schnaar, Ronald L.; Gray, Jeffrey J.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University
  摘要：Noncovalent interaction between proteins and carbohydrates (sugars, glycans) is the basis for biological functions from metabolic regulation to intercellular recognition. It is a grand challenge to identify the protein-carbohydrate interactomes in organisms. Direct experiments would require extensive libraries of glycans to distinguish binding from nonbinding proteins. Computational screening of proteins for carbohydrate binding potential provides an attractive alternative. Current estimates p...