作者：Priovoulos, Nikos; Bazin, Pierre-Louis; Brouwer, Emma J. P.; Mejias, Jorge F.; de Buck, Matthijs H. S.; Alkemade, Anneke; van der Zwaag, Wietske; Caan, Matthan W. A.
作者单位：University of Amsterdam; Royal Netherlands Academy of Arts & Sciences; Spinoza Centre for Neuroimaging (KNAW); University of Oxford; Maastricht University; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW); University of Amsterdam; University of Amsterdam; University of Amsterdam
摘要：The human cerebellar cortex, despite containing the majority of the brain's neurons, remains poorly characterized in vivo due to its extreme folding and thin laminar architecture. Here, we present a high-resolution imaging framework based on parallel-transmit, motion-corrected, ultra-high-field (7T) MRI paired with an automated, anatomically faithful cerebellar segmentation pipeline. This enables detailed quantification of cerebellar morphology and vascular architecture at scales previously in...
作者：Swearer, Dayne F.
作者单位：Northwestern University; Northwestern University; Northwestern University
作者：Verma, Abhishek Kumar; Tan, Lu; Schuster, Noah; Moye, Skyler L.; Lin, Li-Chun; Lowery, Shea; Duraisami, Eazhisaivallabi; Llorens, Juan E. Abrahante; Qiu, Qiang; Hefti, Marco; Meyerholz, David K.; Coleman, Mitchell C.; Yu, C. Ron; Albers, Mark W.; Perlman, Stanley
作者单位：University of Iowa; University of Iowa; University of Iowa; University of Minnesota System; University of Minnesota Twin Cities; Stowers Institute for Medical Research; University of Iowa; University of Iowa; University System of Ohio; Case Western Reserve University; Harvard University; Harvard Medical School
摘要：Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is poorly understood. Here, we report neurological dysfunction for at least 120 d postinfection in mice infected with a virulent nonneurotropic mouse-adapted SARS-CoV-2. Long after recovery from nasal infection, we observed diminished tyrosine hydroxylase expression in olfactory bulb glomeruli and in substantia nigra. Similar changes ...
