2026

最新文章

• Horseshoe bats foraging in the wild adjust sensing to separate prey echoes from background clutter AI翻译
  作者：Yovel, Yossi; Stidsholt, Laura; Mimran, Yotam; Taub, Mor; Greif, Stefan; Hubancheva, Antoniya; Borissov, Ivailo; Weiss, Anthony J.; Denzinger, Annette; Schnitzler, Hans-Ulrich
  作者单位：Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine; Aarhus University; Tel Aviv University; Bulgarian Academy of Sciences; Eberhard Karls University of Tubingen
  摘要：How animals handle immense incoming sensory information and regulate sensing is difficult to study under natural conditions. Using miniature GPS tags with microphones we monitored the sensing of freely foraging greater horseshoe bats. Bats stayed in acoustic contact with the environment and caught insects while commuting and in short flights from a perch. Bats adjusted their call frequency to maintain the highest-frequency echoes from background in a forward-directed, spatially limited sector ...
• Regulatory logic underlying neural crest contributions to the head versus the heart AI翻译
  作者：Gandhi, Shashank; Rajan, Ayyappa Raja Desingu; Urrutia, Hugo; Wilson, Jillian S.; Ling, Irving T. C.; Williams, Ruth; Sauka-Spengler, Tatjana; Bronner, Marianne E.
  作者单位：California Institute of Technology; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Oxford; University of Oxford
  摘要：Neural crest cells exhibit axial-level-specific transcriptional programs, yet the regulatory mechanisms underlying their fate decisions remain unclear. Here, we investigate whether differential transcription factor usage governs cardiac neural crest cell identity. Comparing ATAC-seq profiles of cardiac and cranial neural crest revealed open chromatin regions that were both shared and region-specific. Single-cell RNA sequencing further identified putative target genes, including signaling molec...
• The dynamic mesoscale sink and source niches for eukaryotic phytoplankton in a subtropical gyre AI翻译
  作者：Jones-Kellett, Alexandra E.; McNichol, Jesse C.; Raut, Yubin; Fuhrman, Jed A.; Follows, Michael J.
  作者单位：Massachusetts Institute of Technology (MIT); Woods Hole Oceanographic Institution; University of Hawaii System; University of Hawaii Manoa; University of Southern California; Saint Francis Xavier University - Canada
  摘要：By tracking the water mass histories of genetic samples, we investigated the biophysical dynamics shaping eukaryotic phytoplankton populations in a nutrient-deplete subtropical gyre, where cyanobacteria have a competitive advantage. Triplicate seawater samples were filtered every similar to 46 km along a 2,382 km North Pacific transect, spiked with genomic internal standards, and amplified with a three-domain primer set to obtain absolute 16S and 18S rRNA volumetric gene abundances. The transp...
• Multidecadal preindustrial methane variability can be explained by noise in the source-sink imbalance AI翻译
  作者：Mei, Eric J.; Hakim, Gregory J.; Proistosescu, Cristian; Bauska, Thomas K.; Buizert, Christo; Turner, Alexander J.
  作者单位：University of Washington; University of Washington Seattle; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Oregon State University
  摘要：Ice core records of preindustrial methane indicate variability of +/- 30 ppb (+/- 5%) on multidecadal-to-centennial timescales. Previous work has attributed these excursions to low-frequency or episodic changes in methane sources due to large-scale climate variability (e.g., the Little Ice Age) or human activity. Here, we explore what source and sink dynamics are consistent with ice core variability and show that the preserved variability can arise solely from white noise fluctuations in the s...
• Forests shaped by historical human tragedies: Insights from Europe's oldest angiosperms AI翻译
  作者：Pasques, Ot; Munne-Bosch, Sergi
  作者单位：University of Barcelona; University of Barcelona
• High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds AI翻译
  作者：Yang, Diwen; Wang, Xiaoyun; Liu, Jiabao; Gong, Yufeng; Nair, Pranav; Sun, Jianxian; Qian, Xing; Cui, Jingyuan; Zeng, Hong; Dong, Aiping; Harding, Rachel J.; Burgess-Brown, Nicola; Beyett, Tyler S.; Song, Datong; Krause, Henry M.; Diamond, Miriam L.; Bolhuis, Derek L.; Brown, Nicholas G.; Arrowsmith, Cheryl H.; Edwards, Aled M.; Halabelian, Levon; Peng, Hui
  作者单位：University of Toronto; University Toronto Scarborough; University of Toronto; University of Toronto; University of Toronto; Structural Genomics Consortium; University of Toronto; University of Toronto; University of London; University College London; Emory University; University of Toronto; University of Toronto; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto
  摘要：Chemical pollution is a global threat to human health, yet the toxicity mechanisms of most contaminants remains unknown. Here, we applied an ultrahigh-throughput affinity selection-mass spectrometry (AS-MS) platform to systematically identify protein targets of prioritized chemical contaminants. After benchmarking the platform, we screened 50 human proteins against 481 prioritized chemicals, including 446 ToxCast chemicals and 35 per- and polyfluoroalkyl substances (PFAS). Among 24,050 interac...
• Female dolphins use individual vocal labels to track coercive males AI翻译
  作者：Bouchard, Alice; Allen, Simon J.; Sorensen, Pernille M.; Krutzen, Michael; Marfurt, Svenja M.; Connor, Richard C.; King, Stephanie L.
  作者单位：University of Bristol; University of Zurich; University of Western Australia; Aarhus University; State University System of Florida; Florida International University; State University System of Florida; Florida International University
  摘要：Animals rely on identity signaling to navigate social relationships, assess potential mates, and avoid costly interactions. While species- and group-level recognition signals can provide fitness advantages by preventing inbreeding depression and hybridization, our understanding of the role that individual identity signals can play in mate choice is notably lacking. In species with coercive mating systems, females must carefully evaluate male behavior to minimize risks while also maximizing rep...
• Glycosylation-independent functions for distinct glypican core proteins drive cell-specific responses in corticogenesis AI翻译
  作者：Douceau, Sara; Guerrero, Tanya Deutsch; Borowski, Chloe; Lourenco, Chloe; Weber, Margot; Kavaliova, Hanna; Brault, Emma; Pons, Camille; Roumier, Anne; Wild, Rebekka; Ferent, Julien
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); CEA; Communaute Universite Grenoble Alpes; CNRS - National Institute for Biology (INSB); Universite Grenoble Alpes (UGA)
  摘要：The extracellular matrix plays critical roles in orchestrating cell communication and behaviors in response to various extracellular signals. It is a complex network composed of proteins and polysaccharides, whose individual and synergistic roles in cellular signaling, structural integrity, and tissue homeostasis remain active areas of investigation. Here, we find that in the developing cerebral cortex, distinct glypicans, which are heparan sulfate proteoglycans, present very precise and compl...
• Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity AI翻译
  作者：Liao, Junguang; He, Yiliang; Zhang, Chenyang; Qian, Qitao; Huang, Yuping; Zhang, Qi; Shen, Panpan; Zhou, Chenhe; Wu, Mengrui; Chen, Guiqian
  作者单位：Zhejiang Sci-Tech University; Zhejiang University; Zhejiang University
  摘要：Precise spatiotemporal regulation of parathyroid hormone (PTH) and PTH-related peptide signaling through the parathyroid hormone receptor 1 (PTH1R) is fundamental to skeletal development and metabolic bone remodeling, yet the intracellular mechanisms that fine-tune this signaling remain a central unanswered question. Here, we identify neurofibromin 2 (Nf2) as an essential regulator of PTH1R trafficking and signaling. Conditional knockout of Nf2 in chondrocytes results in short-limbed dwarfism,...
• Social immunity can be a consequence and cause of social evolution AI翻译
  作者：Liu, Ming; Scott, Thomas W.; Shillcock, George; Pull, Christopher D.; West, Stuart A.
  作者单位：University of Oxford; University of Oxford
  摘要：Many social insects respond to pathogens in ways that reduce pathogen transmission within their social groups, with behaviors such as grooming or removing infected individuals. This social immunity within a group has been compared to the immune response of multicellular organisms. However, we lack a theoretical framework for understanding both the possible evolutionary origins and consequences of social immunity. How restrictive are the conditions for the initial evolution of social immunity? ...