2026

最新文章

• ZNF263-NuRD-mediated repression of STAT1 curtails MHC-I antigen presentation and IFN-γ efficacy in prostate cancer AI翻译
  作者：Guan, Han; Mao, Likai; Fang, Fang; Wu, Tiange; Cheng, Yifei; You, Zonghao; Lin, Hao; Zhang, Ruixin; Zhuang, Junyong; Teng, Gao-Jun; Shu, Chuanjun; Ju, Shenghong; Chen, Ming; Li, Wenchao; Xu, Bin
  作者单位：Southeast University - China; Bengbu Medical University; Bengbu Medical University; Southeast University - China; Southeast University - China; Southeast University - China; Nanjing Medical University; Southeast University - China
  摘要：Loss of major histocompatibility complex (MHC)-I is a hallmark of prostate cancer (PCa) immune evasion and immunotherapy failure. Here, we identify ZNF263 as a transcriptional repressor that silences MHC-I by recruiting nucleosome-remodeling and deacetylase (NuRD) to the STAT1 promoter, reducing STAT1 and MHC-I expression. Hypoxia enhances this repression through two ZNF263 modifications: phosphorylation-driven phase separation that strengthens NuRD interaction and O-GlcNAcylation at S662 that...
• Public responses to atrocities depend on partisanship and context, not legal labels AI翻译
  作者：Lelkes, Yphtach; Mitchell, Ellie M.; Walk, Erin; Westwood, Sean J.
  作者单位：University of Pennsylvania; Dartmouth College
  摘要：Legal labels such as genocide and crimes against humanity carry substantial legal and diplomatic weight in elite and institutional arenas, where classification shapes treaty obligations, ICC jurisdiction, and the perceived stakes of inaction. A common assumption in advocacy and policy discourse is that these labels also shape mass public judgment. Direct evidence is limited and ambiguous. We test this assumption in a preregistered, nationally representative survey experiment (N=2,000) comparin...
• FGFR2 is an oncogenic driver critical for successful human gammaherpesvirus latent infection and oncogenesis AI翻译
  作者：Ma, Nian; Bose, Dipayan; Svoboda, Jakob; Chong, Elise A.; Schuster, Stephen J.; Robertson, Erle S.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; University of Pennsylvania
  摘要：Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) drive multiple aggressive lymphomas, yet effective targeted therapies for these virus-associated malignancies remain limited. Using an unbiased kinome-wide screen combined with analysis of virus-positive patient tumors, we identified fibroblast growth factor receptor 2 (FGFR2) as a selectively activated host kinase in EBV- and KSHV-associated lymphomas. Importantly, FGFR2 is required for efficient establishment of EBV ...
• Parabrachial Ntsr1 neurons modulate food intake and anxiety through a projection to the ventromedial hypothalamus AI翻译
  作者：Pauli, Jordan L.; Park, Sekun; Felix, Rachel R.; Palmiter, Richard D.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：The parabrachial nucleus (PBN) is an important hub located in the pons that relays sensory signals from peripheral regions. It is genetically diverse and contains many populations that modulate feeding and responses to threatening situations. A small Ntsr1-expressing population of neurons was identified that projects selectively to the ventromedial hypothalamus (VMH). The Ntsr1 neurons are scattered throughout the lateral PBN with a cluster of cells along the border to the nucleus of the later...
• Integrated thermal and phytoremediation of agricultural soils impacted by PFAS AI翻译
  作者：Thompson, Jake T.; Dobson, Millie; Suhrhoff, Tim Jesper; Kanzaki, Yoshiki; Kent, Chloe; Bryce, Lucinda; Milliken, Ella; Reinhard, Christopher T.; Yao, Yuan; Planavsky, Noah
  作者单位：Yale University; University of Southampton; NERC National Oceanography Centre; Yale University; University System of Georgia; Georgia Institute of Technology; Brown University; Yale University
  摘要：Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic compounds that have contaminated millions of hectares of agricultural land through decades of biosolids application. Conventional remediation approaches, such as thermal destruction or excavation, are prohibitively expensive, carbon intensive, and leave affected farmland unfit for agriculture. Here, we present a potential scalable remediation strategy that combines phytoremediation, biochar production, and enhanced weathering ...
• Shape instabilities of active epithelial domes under hydraulic stress: Growth, collapse, and oscillation AI翻译
  作者：Wu, Dingnan; Guo, Xiaosong; Yang, Yuehua; Jiang, Hongyuan
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Fluid-filled epithelial cavities arise in a wide range of biological contexts, from developmental lumens and embryonic cavities to epithelial domes formed by monolayer delamination. Yet how hydraulic pressure and adhesive rupture coordinate their dynamic shape changes remains poorly understood. Here, using Madin-Darby Canine Kidney (MDCK) epithelial domes as a model system, we combine live imaging with a minimal theoretical model to elucidate the mechanisms governing liquid dome shape dynamics...
• Chromatin end-anchored chromosome-sized domains and promoter loops organize a transcriptionally active genome in Tetrahymena AI翻译
  作者：Hu, Tengfei; Song, Xiaoyuan; Luo, Zhengyu
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Three-dimensional (3D) genome architecture shapes gene regulation, yet the folding principles of compact unicellular genomes remain unclear. Among unicellular eukaryotes, the ciliate Tetrahymena thermophila provides a distinctive model, harboring a transcriptionally active somatic macronucleus (MAC) with a genome fragmented into gene-dense minichromosomes and a silent, intact germline micronucleus. To delineate macronuclear chromatin organization, we integrated nucleosome-resolution Micro-C, A...
• HDA19-mediated deacetylation of histone H3.3 at lysines 27 and 36 regulates plant sensitivity to salt stress AI翻译
  作者：Kotnik, Florian; Ueda, Minoru; Ito, Akihiro; Ishida, Junko; Takahashi, Satoshi; Sakai, Katsuyuki; Takagi, Hiroshi; Seidel, Julian; Abe, Takahiro; Eirich, Jurgen; Takahashi, Shunji; Schwarzer, Dirk; Seki, Motoaki; Finkemeier, Iris
  作者单位：University of Munster; RIKEN; Tokyo University of Pharmacy & Life Sciences; RIKEN; RIKEN; Eberhard Karls University of Tubingen; Yokohama City University; Saitama University
  摘要：Plants survive extreme environments through rapid chromatin reprogramming, yet the epigenetic marks that confer stress resilience remain poorly understood. Histone deacetylase HDA19 is a key epigenetic regulator in Arabidopsis, and hda19-deficient mutants display tolerance to multiple abiotic stresses, including drought, heat, and salinity. Using lysine acetylome profiling, we identified a noncanonical K27/K36 diacetylation mark on histone H3.3, among nine H3 variants, as a specific substrate ...
• Evolvable AI needs operational risk thresholds AI翻译
  作者：Rana, Shweta; Singh, Harpreet
  作者单位：Academy of Scientific & Innovative Research (AcSIR)
• High-resolution structure of monomorphic Aβ1-40 fibrils AI翻译
  作者：Bahri, Salima; Palani, Ravi Shankar; Silvers, Robert; Michael, Brian; Lattanzi, Veronica; Andre, Ingemar; Linse, Sara; Griffin, Robert G.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); State University System of Florida; Florida State University; Lund University
  摘要：Amyloid-beta (A beta) fibrils primarily composed of A beta 1-40 and A beta 1-42 form the core of senile plaques in Alzheimer's disease. A beta 1-40 fibrils may exhibit significant polymorphism influenced by sample preparation conditions, complicating atomic resolution structural characterization. To establish a reliable structural baseline, we developed a protocol for expressing and purifying recombinant A beta 1-40 that forms monomorphic fibrils under physiological conditions (pH 7.4). We pre...